HESS (Heritability Estimation from Summary Statistics)
HESS is a Python package that provides utilities for estimating and analyzing
local SNP-heritability and genetic covariance from GWAS summary
association data. Please see
for details.
Releases
Updates
November 9, 2017: Updated script to allow for columns of arbitrary order
October 30, 2017: Fixed minor bug in handling loci with no SNP
References
- Local SNP-heritability: Shi, Huwenbo, Gleb Kichaev, and Bogdan Pasaniuc. "Contrasting the genetic architecture of 30 complex traits from summary association data." The American Journal of Human Genetics 99, no. 1 (2016): 139-153.
- Local genetic covariance (correlation): Shi, Huwenbo, Nicholas Mancuso, Sarah Spendlove, and Bogdan Pasaniuc. "Local genetic correlation gives insights into the shared genetic architecture of complex traits." The American Journal of Human Genetics 101, no. 5 (2017): 737-751.
Contact
- Huwenbo Shi: shihuwenbo_AT_ucla.edu
- Bogdan Pasaniuc: bpasaniuc_AT_mednet.ucla.edu