i10labtitech / GINGER

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Some issues during my application to the annotation workflow #9

Open Abieskawa opened 1 month ago

Abieskawa commented 1 month ago

Hi, I am trying to apply GINGER to do structural annotate my genome data. Here are my questions:

  1. I finished soft masking with my genome (it takes days), and found that the hard masking is recommended here https://github.com/i10labtitech/GINGER/issues/2#issuecomment-1774895140. But I found that most of people suggest soft mask instead of hard mask in the forums (https://www.biostars.org/p/417941/). Should I use hard masking, or actually, soft masking is feasible?

  2. Another issues is that is ginger possible to integrate annotation of those genome without any rna-seq data?

  3. In your paper, you mentioned that you use GINGER-based parameters to evaluate EVM, how did those parameters calculated?

  4. If one combine multiple RNA-seq data and input GINGER, will it filter those of relatively low expression genes?