jbloomlab / polyclonal

Model mutational escape from polyclonal antibodies.
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regularize epitope activities #89

Closed jbloom closed 2 years ago

jbloom commented 2 years ago

This pull request adds regularization to the epitope activities. The regularization is a Pseudo-Huber function for positive activities, and zero for negative activities. This helps keep activities <= 0 for epitopes that are in unimportant.

Empirically, this improves fitting speed a bit and seems to otherwise give comparable-ish results. The default weight is 1.