You will need all the typical gnome/python bindings. If you're using a recent version of Ubuntu, this line will install them all:
sudo apt-get install python python-glade2 python-gnome2 python-gconf python-gnome2-extras
And (obviously) the LaTeX utilities:
sudo apt-get install texlive-latex-base texlive-base-bin texlive-latex-extra
You will also need pypoppler (for the PDF integration), which can be installed with the following set of commands (again assuming Ubuntu):
sudo apt-get install build-essential libpoppler2 libpoppler-dev libpoppler-glib2 libpoppler-glib-dev python-cairo-dev bzr gnome-common python-dev python-gnome2-dev python-gtk2-dev python-gobject-dev python-pyorbit-dev
bzr branch http://bazaar.launchpad.net/~poppler-python/poppler-python/poppler-0.6-experimental
cd poppler-0.6-experimental
./autogen.sh
./configure
make
sudo make install
Like most editors, run it like this:
python desigle.py [filename]
Please report bugs to the website, and join the listserv:
http://code.google.com/p/desigle/
http://groups.google.com/group/desigle-discuss
Thanks! Derek Anderson