SID_AKI-study

Code repository for the project _“Association of Chloride Ion and Sodium-Chloride Difference With Acute Kidney Injury and Mortality in Critically Ill Patients”._

Inclusion criteria

First admission to ICU
18 years old or older

Data extraction ※The day of ICU admission is “ICU day 0”

Blood gas analysis

Chloride, Sodium, Potassium, Calcium, Magnesium, Lactate, pCO2, Bicarbonate, Base excess, Phosphate, pH, pO2.

• [x] At admission (the first available data 24 hours prior to, or 6 hours after, ICU admission).
• [x] Maximum value, minimum value for 24 hours after ICU admission.
• [x] Maximum value, minimum value for 48 hours after ICU admission.
• time-weighted mean for 24 hours.
• time-weighted mean for 48 hours after ICU admission.

SID (Sodium minus chloride: for this calculation, these ions need to be measured at the same time)

• [x] At admission (the first available data 24 hours prior to, or 6 hours after, ICU admission).
• [x] Maximum value, minimum value for 24 hours after ICU admission.
• [x] Maximum value, minimum value for 48 hours after ICU admission.
• time-weighted mean for 24 hours.
• time-weighted mean for 48 hours after ICU admission.

Lab data

Chloride, Sodium, Potassium, Calcium, Magnesium, Lactate, pCO2, Bicarbonate, Base excess, Phosphate, pH, pO2, SID (=Sodium minus chloride: for this calculation, these ions need to be measured at the same time)

• [x] At admission (the first available data 24 hours prior to, or 6 hours after, ICU admission).
• [x] Maximum value, minimum value for 24 hours after ICU admission.
• [x] Maximum value, minimum value for 48 hours after ICU admission.
• time-weighted mean for 24 hours
• time-weighted mean for 48 hours after ICU admission.

Kidney function

• [x] Creatinine: Baseline (within three months before admission) (if no record, it’s missing value)
• [x] Creatinine: At admission (the first available creatinine 24 hours prior to, or 6 hours after, ICU admission)
• Creatinine: ICU day0, day1, day2, day3, day4, day5, day6, day7 (maximum value on each day) .

Lab data (maximum and minimum) within the first 24 hours and within 48 hours after ICU admission

• [x] Glucose Level (mg/dL)
• [x] Hemoglobin Level (g/dL)
• [x] Hematocrit (%)
• [x] Platelet Count (K/μL)
• [x] Blood Urea Nitrogen Level (mg/dL)
• [x] White Blood Cell Count (K/μL)
• [x] Albumin
  CRP NOT FOUND
• [x] Bilirubin

Vital sign and others: within the first 24 hours after ICU admission

• [x] Heart Rate Maximum (bpm)
• [x] Heart Rate Mean (bpm)
• [x] Systolic BP Minimum (mmHg)
• [x] Systolic BP Mean (mmHg)
• [x] Diastolic BP Minimum (mmHg)
• [x] Diastolic BP Mean (mmHg)
• [x] Temperature Maximum (Celsius) SpO2 Minimum (%)
  SpO2 Mean (%)
  Respiratory rate Maximum (/min)
• [x] Urine output (ml)
  Fluid intake (ml)
  Vasopressors (Noradrenaline, adrenaline, vasopressin, dobutamine, and dopamine) (0 or 1, respectively)

Vital sign and others: within the first 48 hours after ICU admission

• [x] Heart Rate Maximum (bpm)
• [x] Heart Rate Mean (bpm)
• [x] Systolic BP Minimum (mmHg)
• [x] Systolic BP Mean (mmHg)
• [x] Diastolic BP Minimum (mmHg)
• [x] Diastolic BP Mean (mmHg)
• [x] Temperature Maximum (Celsius) SpO2 Minimum (%)

SpO2 Mean (%)
Respiratory rate Maximum (/min)

• [x] Urine output (ml)
  Fluid intake (ml)
  Vasopressors (Noradrenaline, adrenaline, vasopressin, dobutamine, and dopamine) (0 or 1, respectively)

Other covariates

• [x] Gender
• [x] Age
• [x] Weight
• [x] height
• [x] BMI
• [x] BMI Group
• [x] Ethnicity
• [x] ICU type: medical ICU, cardiac ICU, or surgical ICU
• [x] Mechanical Ventilation in the first 24 hours after ICU admission (0 or 1)
• [x] Mechanical Ventilation 48 hours after ICU admission (0 or 1)
• [x] Surgical patient or not (0 or 1) before ICU admission; if so, type of surgery
• [x] Admission type: emergency or not
• [x] Main diagnosis for the admission
  Sepsis (0 or 1)
  Burn (0 or 1)
  Trauma (0 or 1)
  Pre-ICU length of stay in hospital (days)

Outcomes

AKI (0 or 1) and the stage (1, 2, or 3) (using KDIGO criteria based on creatinine, urine output, and renal
replacement therapy): within 7 days after ICU admission and the date of the development of AKI (ex.ICU day2 etc)
ICU mortality (0 or 1)

• [x] Hospital mortality (0 or 1)
• [x] Length of stay in ICU
• [x] Length of stay in hospital
• [x] Length of mechanical ventilation
  Length of renal replacement therapy

Medication (Before or at the time of admission)

Diuretic (0 or 1)
ACE-I (0 or 1)
ARB (0 or 1)
Calcium channel blocker (0 or 1)
β blocker (0 or 1)

Severity score (ICU day 0 and ICU day 1)

SOFA
APACHE III

Past medical history

• [x] Congestive heart failure
• [x] Peripheral vascular disease
• [x] Hypertension
• [x] Chronic pulmonary disease
• [x] Diabetes mellitus
• [x] Chronic liver disease
• [x] Malignancy