SC_postnatal_adult

"Spermatogonial cells are the postnatal initiators of spermatogenesis, and they undertake critical proliferative and differentiation tasks throughout one’s life. They are the only type of stem cell capable of transmitting genetic information to an embryo. Chromatin in spermatogonial cells undergoes significant remodelling throughout testes development. Throughout postnatal testes development, they have significantly different transcriptional pathways. We investigated the dynamics of chromatin accessibility and gene expression during the developmental stages of postnatal day 8 (PND8), PND15, and postnatal week 21 (PNW21) using multi-omics data collected from spermatogonial cells."

-- Deepak Tanwar thesis: https://doi.org/10.3929/ethz-b-000537329

Code description

This repository contain code for data analysis for the manuscript:

Irina Lazar-Contes and Deepak K. Tanwar et.al.: Transcriptome and epigenome characterization of mouse spermatogonial cells reveals distinct chromatin regulatory landscapes in postnatal and adult testis

This repository contains data analysis code for:

1. Code version 1: Manuscript on BioRxiv

2. Code version 2: Irina Lazar thesis

3. Code version 3: Analysis and integration of data from Cheng et. al.

4. Code version 4: New sequencing data analysis and inclusion in Deepak Tanwar thesis

5. Code version 5: Any further analysis after Deepak Tanwar thesis submission

Datasets analysed in this study