Have a look at Mr. Fusion, a universal MiSTer installation image that may provide a more user friendly installation experience.
That said, the script described below should still work.
This script automates the creation of a MiSTer SD card on macOS. It covers up until the step "Get a core" in the MiSTer Wiki Setup Guide. Tested on macOS Mojave 10.14.2
Running this script on an empty SD card will install the following:
Once your SD card is ready you can put it into your MiSTer board, configure a controller and run the MiSTer update script. This will install the latest versions of the MiSTer binary, the menu and the MiSTer cores. Make sure your MiSTer board is connected to the Internet using ethernet.
Open a terminal, clone this repository and change into the directory.
git clone https://github.com/michaelshmitty/SD-Installer-macos_MiSTer.git
cd SD-Installer-macos_MiSTer
Find out your SD card device. This is important because the script will wipe everything on that device and selecting the wrong device could lead to data loss.
First, keep your SD card unplugged and list the currrently known disks:
diskutil list
Then insert your SD card and issue the command again. Your SD card should now show up in the list. Usually it's /dev/disk2 but not always.
diskutil list
Now run the macOS MiSTer SD card installer script with the correct disk, for example /dev/disk2. Some commands require the sudo command so you may be prompted for your password.
./MiSTer-sd-installer-macos.sh /dev/disk2
If everything went well you should now have a clean MiSTer SD card which you can put into your MiSTer board and boot from.
Once booted you will be greeted by the MiSTer interface. Attach a keyboard and make sure your MiSTer board is connected to the internet through the ethernet interface. Hit F12 on the keyboard and navigate to Scripts. Then open the #Scripts directory, select the update script and hit enter. The MiSTer update script will now install the latest versions of the MiSTer binary, the menu and the available MiSTer cores.
Thanks to great contributions by rwk-git and corttompkins we now have a Linux compatible version of the script as well.
If you run into any problems, open an issue and I'll try to address it asap.