Open ammaraziz opened 3 months ago
Thanks for the issues @ammaraziz! Could you send me those sequences from Australia? Just the fasta is fine, no need for any metadata! You can either post them here or send via email/Slack. Would be helpful for designation purposes.
Using a single defining mutation should be ok here as it is part of a not so huge polytomy - in contrast to the original B.1 outbreak where using just one SNP is asking for ambiguity in tree building/lineage definition.
It would be amazing if I could see the sequences - while I trust you, it's always good to make decisions based on data :)
Second proposal for a sublineage of B.1.20. The proposed sublineage is found in USA from public data but soon there will be more from Australia.
https://nextstrain.org/mpox/lineage-B.1?branchLabel=aa&c=gt-OPG117_297&gmax=98406&gmin=96049
Mutations
New sequences from Australia sit in the lower branch of
B.1.20+OPG117:S297L
which is defined by only nucleotidesG23100A, C50572T, C176642T
This one is a tad tricky as there's a clear sub-sub-lineage within the proposed
B.1.20+OPG117:S297L
, which I will callB.1.20 + OPG117:S297L + OPG029:R108C
Unsure if
B.1.20 + OPG117:S297L + OPG029:R108C
should be designated a new sublineage alongside the above sublineage. It does not meet the criteria ofhas spread internationally