Proposal for B.1.6 sublineage OPG025:A21T,E34K and others

[Vjimenez-vasquez]

Description

Potential new hMPXV B.1.6. lineage identified in Peru by the Genomic Surveillance of the Instituto Nacional de Salud (INS-Peru)*. Lineage is defined by numerous mutations, deletions and stop codon as follows:

OPG019: Q81stop OPG025: A21T, E34K OPG121: S65L OPG153: D385del OPG210: S1590F

Genomes

Earliest sequence: 2023-07-12 Most recent sequence: 2024-06-01

Countries circulating

Major clade: Peru (92 genomes)

GISAID codes

EPICodes.txt

Evidence

1. Global Phylogeny

2. New Clade

3. Alignment

[ammaraziz]

@Vjimenez-vasquez are you able to submit these to ncbi/genbank?

[Vjimenez-vasquez]

@Vjimenez-vasquez are you able to submit these to ncbi/genbank?

Hi @ammaraziz, we will discuss the submission to NCBI/genbank in the INS-PERU team. But in the case you need the genome sequences, we can load the genomes here.

[LuisBarcenaF]

The **B.1.6.*** lineage continues in circulation, even in September it has been detected

[Wen1953]

Designated as B.1.6.1, 78 genomes in GISAID so far.

[Vjimenez-vasquez]

Designated as B.1.6.1, 78 genomes in GISAID so far.

Please @corneliusroemer. I would appreciate consideration of this lineage that is now visible in GISAID.

[ammaraziz]

@Vjimenez-vasquez Sorry for the delay. I'm volunteering to help the mpox designation team with these proposals.

Any luck with getting permission to upload sequences to genbank? We (Australia) have seen a single B.1.6, but as there are little publicly available data it's been hard to pinpoint where it starts.

[ammaraziz]

There's also a possibility that Peru sequences contain more sublinages.

[corneliusroemer]

Thanks everyone!

Dropping the most recent (collected since 2023-01-01) Peruvian sequences from GISAID into Nextclade it looks pretty clear that there's one big sublineage, it's the same branch we see in the public sequences

I think one could cut like this: