Single trial vs sequential trial approaches for estimating COVID-19 vaccine effectiveness

This is the code and configuration for the paper entitled "Challenges in estimating the effectiveness of COVID-19 vaccination using observational data". This paper compares two approaches to target trial emulation for estimating COVID-19 vaccine effectiveness: the single trial approach and the sequential trial approach.

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• If you are interested in how we defined our code lists, look in the codelists folder.
• Developers and epidemiologists interested in the framework should review the OpenSAFELY documentation

project.yaml

The project.yaml defines run-order and dependencies for all the analysis scripts. It is split into a series of "actions", each one implementing a step in the analysis pipeline. The file is annotated to describe the purpose of each action. This file is where you should start if you wish to understand the analysis pipeline.

The project.yaml should not be edited directly. To make changes, edit and run the create-project.R script instead. There is no need to run create_project.R if you are simply cloning this repo.

About the OpenSAFELY framework

The OpenSAFELY framework is a Trusted Research Environment (TRE) for electronic health records research in the NHS, with a focus on public accountability and research quality.

Read more at OpenSAFELY.org.

Licences

As standard, research projects have a MIT license.