OSA Meeting Friday December 11th 2020

[edwintse]

Meeting Dec 11th 2020 at 2pm UK time at https://ucl.zoom.us/j/92800004715. This page follows on from #44.

Recording is [here].

On the call:

1. Screening. a) Next potency screen: 13 compounds given on Tues 8/12 #46. Currently awaiting results.

b) Human Cytotox: Happening in the lab of Andreas Schatzlein. This is also to test the metal-binding potential of the 2-pyridyl system. More information at issue #3 .

2. Synthetic Chemistry Update by @edwintse and @danaklug. See below for slide.

3. in vitro PK: a) Benzofuran compound (821) sent for metabolic ID by Hypha. Awaiting results.

4. Community updates a) Newsletters. Another one needed, on Series 1 this time. Action on @mattodd. People need to give their consent to be emailed, and we need a record of that. Google form for sign-up here. Link to be added to OSA GH landing page.... and elsewhere? Action on @danaklug , also to copy over existing newsletter recipient names to the sheet.

5. Molecule contributions Crowdsourcing of physical compounds. @danaklug to look at landing page for molecule contributions: template now available at #39. Google form link also at #39 and here.

Donation terms are at #45. @drc007 has reached out to people in his professional network to see if these terms are OK. Good comments back, some discussion in meeting needed.

6. Mechanism of action: Results received via email and have been shared here, discussion at #15. Action on @edwintse to ensure the data are also installed on Labarchives and linked to Github, to ensure we don't lose such crucial files.

7. Series Origin/Similarity Landscape: Mat has received clearance for the GSK conversation Action on @mattodd to post. Done here.

8. ELN. @danaklug or @edwintse to try again (Action) Labarchives' molecule sketching facility to see if the ELN page is Google-able. i.e. sketch a molecule from OSA using the drawing facility, and check each day to see if it is indexed. ELN pages on which strings have been manually pasted are indexed (@mattodd checked this yesterday). Can we do away with manual strings pasting? Separately, @mattodd found that the OSA molecule spreadsheet is not indexed. @drc007 said he would check this out (Action).

AOB

• @mattodd mentioned the value of having a Twitter Bot that takes a molecule from the OSA spreadsheet and tweets out the structure with the strings and with a page where it is clear what the use of the molecule is. This allows for human to spot the molecules that OSA requires.

• (ongoing -> install in wiki as a way of working) @mattodd also reminded people to keep an eye on sites such as Enamine, Manifold and Mcule, to check whether any molecules might be commercially available. We should always try to make the challenging molecules in the lab, and buy the others.

Actions (can be checked as complete after the meeting).

• [x] ACTION ITEM: Lori to ship some compounds to UCL for MRSA eval
• [x] ACTION ITEM: Lori to dig up relevant tox data on these compounds
• [x] ACTION ITEM: Mat to report back on Hypha.
• [x] ACTION ITEM: Mat to report back from GSK on what can be shared publicly about the series history.
• [ ] ACTION ITEM: Chris to look into why the OSA molecule sheet is not Google-indexed.
• [x] ACTION ITEM: Mat to look into license terms for compound donation - see #45
• [x] ACTION ITEM: Chris to reach out to professional network for compound donations
• [ ] ACTION ITEM: This meeting to be posted on YouTube.

[mattodd]

Item of AOB: Github has a new thing called Discussions that we can switch on. i.e. discussions without using Issues. I don't know if this would be useful, if someone would like to check it out. Happy to switch it on for a trial.

[danaklug]

Google form for submitting proposed comounds is here and the response spreadsheet can be accessed here. Does this work well? Anything we should add?

[MFernflower]

@danaklug I test deposited one of my compound ideas into the sheet

[drc007]

Looks good - Chris