This repository contains everything to do with the second series conducted by Open Source Antibiotics, which is an open source drug discovery project. The focus is the discovery and development of new antibiotics, specifically the optimisation of a series of molecules discovered at the University of North Carolina Chapel Hill.
Aim 1 is to alter the structures of the molecules in order to maintain potency while improving metabolic clearance.
Aim 2 is to discover the mechanism of action.
As an open source project you can be involved as a full participant. For a brief outline of what this means, take a look at this "about" page over at Open Source Malaria or read about the six laws that summarise how it all works.
To learn more about the background to the project and where we're up to, click on the Wiki tab above. To learn about the current needs of the project and how to get involved, click on the Issues tab, also above. All files related to the project are either within online lab notebooks (see "Sources of Data" on the wiki) or are on this page (above) in the shared file structure.
Click here to sign up for our newsletter.
If you're participating and would like to advertise this fact, or if you like the project and want to promote it, you can use this resource.
Click here to find out how to donate compound samples for testing, or to submit proposed compounds for synthesis.
Unless otherwise stated, all content in Open Source Antibiotics should be taken to be governed by the Creative Commons CC-BY-4.0 licence.