Apparently incorrect tractability precedence for HDAC4

[d0choa]

Reported by user,

I was using the tractability data to help guide selection of targets ... and noticed a discrepancy for HDAC4 in that the marketed drugs/clinical candidates are flagged (correctly) on the OT and ChEMBL websites but in the tractability section this isn't the case (plus, I am not sure that the number of chembl compounds is correct either).

HDAC4 target page: https://platform.opentargets.org/target/ENSG00000068024

[hioannidis]

The changes I made are outlined below:

• Change the full URL in the run_pipeline.py and include the "reviewed" category.

full_url = 'https://rest.uniprot.org/uniprotkb/stream?fields=accession%2Cid%2Cprotein_name%2Cgene_primary%2Cgene_synonym%2Cxref_geneid%2Cxref_chembl%2Cxref_bindingdb%2Cxref_drugbank%2Cxref_pharmgkb%2Cxref_pharos%2Cxref_pdb%2Ccc_subcellular_location%2Cft_transmem%2Cft_signal%2Cgo_c%2Creviewed&format=tsv&query=%28proteome:UP000005640%29'

• Included only reviewed results and where uniprot accession is less than 7 characters.

human_proteome.query(" `Entry Name` == `Entry Name` & `Reviewed` == 'reviewed' & Entry.str.len() < 7 ", inplace = True) human_proteome = human_proteome.drop(columns = ['Reviewed'])

Feel free to close this issue as the submission for 24.06 is complete and reopen it if there are more issues.

[ireneisdoomed]

The issue is solved with the latest submission. Thank you for the fix @hioannidis! I'll keep this open to double check in the FE

[prashantuniyal02]

This has been resolved in the latest dev version and will be fixed with the Platform 24.06 release.