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paul-buerkner / brms

brms R package for Bayesian generalized multivariate non-linear multilevel models using Stan
https://paul-buerkner.github.io/brms/
GNU General Public License v2.0
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bayesian-inference brms multilevel-models r-package stan statistical-models

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brms

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Overview

The brms package provides an interface to fit Bayesian generalized (non-)linear multivariate multilevel models using Stan, which is a C++ package for performing full Bayesian inference (see https://mc-stan.org/). The formula syntax is very similar to that of the package lme4 to provide a familiar and simple interface for performing regression analyses. A wide range of response distributions are supported, allowing users to fit – among others – linear, robust linear, count data, survival, response times, ordinal, zero-inflated, and even self-defined mixture models all in a multilevel context. Further modeling options include non-linear and smooth terms, auto-correlation structures, censored data, missing value imputation, and quite a few more. In addition, all parameters of the response distribution can be predicted in order to perform distributional regression. Multivariate models (i.e., models with multiple response variables) can be fit, as well. Prior specifications are flexible and explicitly encourage users to apply prior distributions that actually reflect their beliefs. Model fit can easily be assessed and compared with posterior predictive checks, cross-validation, and Bayes factors.

Resources

How to use brms

library(brms)

As a simple example, we use poisson regression to model the seizure counts in epileptic patients to investigate whether the treatment (represented by variable Trt) can reduce the seizure counts and whether the effect of the treatment varies with the (standardized) baseline number of seizures a person had before treatment (variable zBase). As we have multiple observations per person, a group-level intercept is incorporated to account for the resulting dependency in the data.

fit1 <- brm(count ~ zAge + zBase * Trt + (1|patient),
            data = epilepsy, family = poisson())

The results (i.e., posterior draws) can be investigated using

summary(fit1)
#>  Family: poisson 
#>   Links: mu = log 
#> Formula: count ~ zAge + zBase * Trt + (1 | patient) 
#>    Data: epilepsy (Number of observations: 236) 
#>   Draws: 4 chains, each with iter = 2000; warmup = 1000; thin = 1;
#>          total post-warmup draws = 4000
#> 
#> Multilevel Hyperparameters:
#> ~patient (Number of levels: 59) 
#>               Estimate Est.Error l-95% CI u-95% CI Rhat Bulk_ESS Tail_ESS
#> sd(Intercept)     0.59      0.07     0.46     0.74 1.01      566     1356
#> 
#> Regression Coefficients:
#>            Estimate Est.Error l-95% CI u-95% CI Rhat Bulk_ESS Tail_ESS
#> Intercept      1.78      0.12     1.55     2.01 1.00      771     1595
#> zAge           0.09      0.09    -0.08     0.27 1.00      590     1302
#> zBase          0.71      0.12     0.47     0.96 1.00      848     1258
#> Trt1          -0.27      0.16    -0.60     0.05 1.01      749     1172
#> zBase:Trt1     0.05      0.17    -0.30     0.38 1.00      833     1335
#> 
#> Draws were sampled using sampling(NUTS). For each parameter, Bulk_ESS
#> and Tail_ESS are effective sample size measures, and Rhat is the potential
#> scale reduction factor on split chains (at convergence, Rhat = 1).

On the top of the output, some general information on the model is given, such as family, formula, number of iterations and chains. Next, group-level effects are displayed separately for each grouping factor in terms of standard deviations and (in case of more than one group-level effect per grouping factor; not displayed here) correlations between group-level effects. On the bottom of the output, population-level effects (i.e. regression coefficients) are displayed. If incorporated, autocorrelation effects and family specific parameters (e.g., the residual standard deviation ‘sigma’ in normal models) are also given.

In general, every parameter is summarized using the mean (‘Estimate’) and the standard deviation (‘Est.Error’) of the posterior distribution as well as two-sided 95% credible intervals (‘l-95% CI’ and ‘u-95% CI’) based on quantiles. We see that the coefficient of Trt is negative with a zero overlapping 95%-CI. This indicates that, on average, the treatment may reduce seizure counts by some amount but the evidence based on the data and applied model is not very strong and still insufficient by standard decision rules. Further, we find little evidence that the treatment effect varies with the baseline number of seizures.

The last three values (‘ESS_bulk’, ‘ESS_tail’, and ‘Rhat’) provide information on how well the algorithm could estimate the posterior distribution of this parameter. If ‘Rhat’ is considerably greater than 1, the algorithm has not yet converged and it is necessary to run more iterations and / or set stronger priors.

To visually investigate the chains as well as the posterior distributions, we can use the plot method. If we just want to see results of the regression coefficients of Trt and zBase, we go for

plot(fit1, variable = c("b_Trt1", "b_zBase"))

A more detailed investigation can be performed by running launch_shinystan(fit1). To better understand the relationship of the predictors with the response, I recommend the conditional_effects method:

plot(conditional_effects(fit1, effects = "zBase:Trt"))

This method uses some prediction functionality behind the scenes, which can also be called directly. Suppose that we want to predict responses (i.e. seizure counts) of a person in the treatment group (Trt = 1) and in the control group (Trt = 0) with average age and average number of previous seizures. Than we can use

newdata <- data.frame(Trt = c(0, 1), zAge = 0, zBase = 0)
predict(fit1, newdata = newdata, re_formula = NA)
#>      Estimate Est.Error Q2.5 Q97.5
#> [1,]  5.91200  2.494857    2    11
#> [2,]  4.57325  2.166058    1     9

We need to set re_formula = NA in order not to condition of the group-level effects. While the predict method returns predictions of the responses, the fitted method returns predictions of the regression line.

fitted(fit1, newdata = newdata, re_formula = NA)
#>      Estimate Est.Error     Q2.5    Q97.5
#> [1,] 5.945276 0.7075160 4.696257 7.450011
#> [2,] 4.540081 0.5343471 3.579757 5.665132

Both methods return the same estimate (up to random error), while the latter has smaller variance, because the uncertainty in the regression line is smaller than the uncertainty in each response. If we want to predict values of the original data, we can just leave the newdata argument empty.

Suppose, we want to investigate whether there is overdispersion in the model, that is residual variation not accounted for by the response distribution. For this purpose, we include a second group-level intercept that captures possible overdispersion.

fit2 <- brm(count ~ zAge + zBase * Trt + (1|patient) + (1|obs),
            data = epilepsy, family = poisson())

We can then go ahead and compare both models via approximate leave-one-out (LOO) cross-validation.

loo(fit1, fit2)
#> Output of model 'fit1':
#> 
#> Computed from 4000 by 236 log-likelihood matrix.
#> 
#>          Estimate   SE
#> elpd_loo   -671.7 36.6
#> p_loo        94.3 14.2
#> looic      1343.4 73.2
#> ------
#> MCSE of elpd_loo is NA.
#> MCSE and ESS estimates assume MCMC draws (r_eff in [0.4, 2.0]).
#> 
#> Pareto k diagnostic values:
#>                          Count Pct.    Min. ESS
#> (-Inf, 0.7]   (good)     228   96.6%   157     
#>    (0.7, 1]   (bad)        7    3.0%   <NA>    
#>    (1, Inf)   (very bad)   1    0.4%   <NA>    
#> See help('pareto-k-diagnostic') for details.
#> 
#> Output of model 'fit2':
#> 
#> Computed from 4000 by 236 log-likelihood matrix.
#> 
#>          Estimate   SE
#> elpd_loo   -596.8 14.0
#> p_loo       109.7  7.2
#> looic      1193.6 28.1
#> ------
#> MCSE of elpd_loo is NA.
#> MCSE and ESS estimates assume MCMC draws (r_eff in [0.4, 1.7]).
#> 
#> Pareto k diagnostic values:
#>                          Count Pct.    Min. ESS
#> (-Inf, 0.7]   (good)     172   72.9%   83      
#>    (0.7, 1]   (bad)       56   23.7%   <NA>    
#>    (1, Inf)   (very bad)   8    3.4%   <NA>    
#> See help('pareto-k-diagnostic') for details.
#> 
#> Model comparisons:
#>      elpd_diff se_diff
#> fit2   0.0       0.0  
#> fit1 -74.9      27.2

The loo output when comparing models is a little verbose. We first see the individual LOO summaries of the two models and then the comparison between them. Since higher elpd (i.e., expected log posterior density) values indicate better fit, we see that the model accounting for overdispersion (i.e., fit2) fits substantially better. However, we also see in the individual LOO outputs that there are several problematic observations for which the approximations may have not have been very accurate. To deal with this appropriately, we need to fall back to other methods such as reloo or kfold but this requires the model to be refit several times which takes too long for the purpose of a quick example. The post-processing methods we have shown above are just the tip of the iceberg. For a full list of methods to apply on fitted model objects, type methods(class = "brmsfit").

Citing brms and related software

Developing and maintaining open source software is an important yet often underappreciated contribution to scientific progress. Thus, whenever you are using open source software (or software in general), please make sure to cite it appropriately so that developers get credit for their work.

When using brms, please cite one or more of the following publications:

As brms is a high-level interface to Stan, please additionally cite Stan (see also https://mc-stan.org/users/citations/):

Further, brms relies on several other R packages and, of course, on R itself. To find out how to cite R and its packages, use the citation function. There are some features of brms which specifically rely on certain packages. The rstan package together with Rcpp makes Stan conveniently accessible in R. Visualizations and posterior-predictive checks are based on bayesplot and ggplot2. Approximate leave-one-out cross-validation using loo and related methods is done via the loo package. Marginal likelihood based methods such as bayes_factor are realized by means of the bridgesampling package. Splines specified via the s and t2 functions rely on mgcv. If you use some of these features, please also consider citing the related packages.

FAQ

How do I install brms?

To install the latest release version from CRAN use

install.packages("brms")

The current developmental version can be downloaded from GitHub via

if (!requireNamespace("remotes")) {
  install.packages("remotes")
}
remotes::install_github("paul-buerkner/brms")

Because brms is based on Stan, a C++ compiler is required. The program Rtools (available on https://cran.r-project.org/bin/windows/Rtools/) comes with a C++ compiler for Windows. On Mac, you should install Xcode. For further instructions on how to get the compilers running, see the prerequisites section on https://github.com/stan-dev/rstan/wiki/RStan-Getting-Started.

I am new to brms. Where can I start?

Detailed instructions and case studies are given in the package’s extensive vignettes. See vignette(package = "brms") for an overview. For documentation on formula syntax, families, and prior distributions see help("brm").

Where do I ask questions, propose a new feature, or report a bug?

Questions can be asked on the Stan forums on Discourse. To propose a new feature or report a bug, please open an issue on GitHub.

How can I extract the generated Stan code?

If you have already fitted a model, apply the stancode method on the fitted model object. If you just want to generate the Stan code without any model fitting, use the stancode method on your model formula.

Can I avoid compiling models?

When you fit your model for the first time with brms, there is currently no way to avoid compilation. However, if you have already fitted your model and want to run it again, for instance with more draws, you can do this without recompilation by using the update method. For more details see help("update.brmsfit").

What is the difference between brms and rstanarm?

The rstanarm package is similar to brms in that it also allows to fit regression models using Stan for the backend estimation. Contrary to brms, rstanarm comes with precompiled code to save the compilation time (and the need for a C++ compiler) when fitting a model. However, as brms generates its Stan code on the fly, it offers much more flexibility in model specification than rstanarm. Also, multilevel models are currently fitted a bit more efficiently in brms. For detailed comparisons of brms with other common R packages implementing multilevel models, see vignette("brms_multilevel") and vignette("brms_overview").