ctypesgen
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(c) Ctypesgen developers 2007-2011
http://code.google.com/p/ctypesgen/
ctypesgen is a pure-python ctypes wrapper generator. It can also output JSON, which can be used with Mork, which generates bindings for Lua, using the alien module (which binds libffi to Lua).
ctypesgen is distributed under the New (2-clause) BSD License: http://www.opensource.org/licenses/bsd-license.php
libffi is a portable Foreign Function Interface library: http://sources.redhat.com/libffi/
Mork, the friendly alien, can be found at: https://github.com/rrthomas/mork
To get JSON output, use --output-language=json. When outputting JSON, you will probably want to use --all-headers --builtin-symbols --no-stddef-types --no-gnu-types --no-python-types too.