TAARs and VN1Rs are getting mangled and their helices broken apart. The current generate_couples code is only compatible with OR sequences; the other receptors must not have enough of the right contact residues.
Want to modify generate_couples to use a different set of contacts for TAARs, based on the experimental models in the pdbs/ folder showing the coupling of mTAAR9 with G proteins.
Also want to modify the script to not attempt to couple MS4As, since these are not G-protein coupled receptors. Would like to devise a way to categorize receptors into categories including GPCR and "other" at least until the mechanism of MS4A activation and signalling is determined and those can be given their own category.
TAARs and VN1Rs are getting mangled and their helices broken apart. The current generate_couples code is only compatible with OR sequences; the other receptors must not have enough of the right contact residues.
Want to modify generate_couples to use a different set of contacts for TAARs, based on the experimental models in the
pdbs/
folder showing the coupling of mTAAR9 with G proteins.Also want to modify the script to not attempt to couple MS4As, since these are not G-protein coupled receptors. Would like to devise a way to categorize receptors into categories including GPCR and "other" at least until the mechanism of MS4A activation and signalling is determined and those can be given their own category.