sars-cov-2-variants / lineage-proposals

Repository to propose and discuss lineages
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Multiple EG.5.1* Lineages with S:L455F #537

Closed NkRMnZr closed 11 months ago

NkRMnZr commented 1 year ago

### Multiple EG.5.1\* Lineages with S:L455F or S:L455S
- [x] [Branch 1](#branch_1): Designated as HK.8 via [cov-lineages/pango-designation@`9527e15`](https://github.com/cov-lineages/pango-designation/commit/9527e15afb0acedf720e1042d5da347a4c0abd7d) , after transferred to cov-lineages/pango-designation#2230 , Phylogenetic order follows: EG.5.1.1 > C11779T > `G22927T`(**S:L455F**)
- [ ] [Branch 2](#branch_2): Transferred to cov-lineages/pango-designation#2229 EG.5.1.1 > C12053T(ORF1a:L3930F) > C503T(ORF1a:P80S) > C7732T, C18175T(ORF1b:P1570S), `G22927T`(**S:L455F**)
- [x] [Branch 3](#branch_3): Designated as **HK.14** via [cov-lineages/pango-designation@`c7550b1`](https://github.com/cov-lineages/pango-designation/commit/c7550b14adc5cff2e855903e3841458886c3073c) , after transferred to cov-lineages/pango-designation#2194 , Phylogenetic order follows: EG.5.1.1 > C11779T > C6781T, C17802T, `G22927C`(**S:L455F**)
- [x] [Branch 4](#branch_4): Designated as **EG.5.1.8** via [cov-lineages/pango-designation@`072c887`](https://github.com/cov-lineages/pango-designation/commit/072c887d266647163602965c26d74a389ae8175a) after transferred to cov-lineages/pango-designation#2224 , Phylogenetic order follows: EG.5.1 > `G22927T`(**S:L455F**)
- [x] [Branch 5](#branch_5): Designated as **HK.13** via [cov-lineages/pango-designation@`49cdcb4`](https://github.com/cov-lineages/pango-designation/commit/49cdcb4cc5fe60cf6826fbdb9580ccedf22d3e33) , after transferred to cov-lineages/pango-designation#2250 , Phylogenetic order follows: EG.5.1.1 > `G22927C`(**S:L455F**)
- [ ] [Branch 7](#branch_7): ~~EG.5.1.1 > C6627T(ORF1a:T2121I) > T17147C(ORF1b:I1227T) > `G22927T`(**S:L455F**) [Query: `C6627T, T17147C, G22927T`, 51 seqs, 01/19]~~ Slow
- [ ] [Branch 8](#branch_8): EG.5.1.1 > C5284T > T14655C > C15951T, `G22927T`(**S:L455F**) [Query:`C5284T, T14655C, G22927T`, 68 seqs, 01/18]
- [ ] [Branch 9](#branch_9): **WITHDRAWN ex-HK.10 (EG.5.1.1.10)** via [cov-lineages/pango-designation@`f655671`](https://github.com/cov-lineages/pango-designation/commit/f6556710dd5e198e827b227bd3db24ae11b45c74) Phylogenetic order follows: EG.5.1.1 > C19983T > `G22927T`(**S:L455F**) ⚠️ No Longer tracking, there are now a lot of **HK.3** sublineages with `C19983T`, this seems weirdly homoplastic.
- [ ] [Branch 10](#branch_10): Retracted from cov-lineages/pango-designation#2251 EG.5.1.1 > C11173T > `G22927T`(**S:L455F**) [Query: `C11173T, G13627A, G22927T, -T10837G, -T15042C, -T22228C, -C27406T, -T28157C`, 739 seqs, 01/19]
- [ ] [Branch 11](#branch_11): EG.5.1 > C9430T > C20873G(ORF1b:A2469G), `G22927T`(**S:L455F**) [Query: `C9430T, G21718T, G22927T, -C1889T, -G13627A, -C21622A`, 53, 01/12]
- [x] [Branch 12](#branch_12): Designated as **EG.5.1.17**, phylogenetic order follows: EG.5.1 > `G22927C`(**S:L455F**) [Query: `C2334T, A18492G, G22927C, -G1069A, -A22106C, -C22570T, -C25572T`]
- [ ] [Branch 13](#branch_13): Transferred to cov-lineages/pango-designation#2364 EG.5.1.1 > C19011T > C8991T(ORF1a:A2909V) > `G22927T`(**S:L455F**)
- [ ] [Branch 14](#branch_14): ~~EG.5.1.1 > A8443G > `G22927T`(**S:L455F**) [Query: `C6541T, A8443G, G22927T, -T4579A`, 7 seqs, 10/12]~~ Dead
- [x] [Branch 15](#branch_15): Designated with three levels: **HK.23**, **HK.23.1** and **HK.23.1.1** after Transferred to cov-lineages/pango-designation#2340 EG.5.1.1 > C28087T(ORF8:A65V) > `G22927T`(**S:L455F**), many with further `S:A348S`
- [ ] [Branch 16](#branch_16): ~~EG.5.1.1 > C8074T, T17811C > C7604T, C10789T, C10834T, C12815T, G20348T(ORF1b:S2294I), `G22927C`(**S:L455F**), A25998G [Query: `C6541T, C8074T, G22927C`, 13 seqs, 01/19]~~ Slow
- [ ] [Branch 17](#branch_17): Transferred to cov-lineages/pango-designation#2341 EG.5.1.1 > C9118T > G16813T(ORF1b:V1116L), `G22927T`(**S:L455F**)
- [x] [Branch 20](#branch_20): Designated **HK.33**, phylogenetic order follows: EG.5.1.1 > C2644T > T7957C, `G22927T`(**S:L455F**), G29348T(N:A359S) [Query: `C2644T, G13627A, G22927T`]
- [x] [Branch 23](#branch_23): Designated as **HK.2.1** via [cov-lineages/pango-designation@`d75dabe`](https://github.com/cov-lineages/pango-designation/commit/d75dabedbd433e944eeaee05222453dbda071cf1) after transferred to cov-lineages/pango-designation#2319 , phylogenetic order follows: **HK.2 (EG.5.1.1.2)** > G22927T(**S:L455F**)
- [x] [Branch 24](#branch_24): Designated as **`HK.20`** via [cov-lineages/pango-designation@`71cf97b`](https://github.com/cov-lineages/pango-designation/commit/71cf97b211299abf8f997396b40419285016b435) after transferred to cov-lineages/pango-designation#2353 , phylogenetic order follows: EG.5.1.1 > C6695T(ORF1a:P2144S) > C9448A > C5575T, G22927T(**S:L455F**)
- [ ] [Branch 25](#branch_25): EG.5.1.1 > C29296T > G22927T(**S:L455F**) [Query: `C6541T, G22927T, C29296T`, 70 seqs, 01/17] (Mostly with `S:A684V`)
- [x] [Branch 26](#branch_26): Designated as **HK.11.1** via [cov-lineages/pango-designation@`e268dbf`](https://github.com/cov-lineages/pango-designation/commit/e268dbfb10735703aeec95cf82092020689f4f4d) after transferred to cov-lineages/pango-designation#2320 , phylogenetic order follows **HK.11** > T13228C > T4789A > G22927T(**S:L455F**)
- [ ] [Branch 27](#branch_27): Transferred to cov-lineages/pango-designation#2342 EG.5.1.1 > C25493A(ORF3a:T34K) > G28884C(**N:G204P**) > G22927T(**S:L455F**)
- [ ] [Branch 28](#branch_28): Transferred to cov-lineages/pango-designation#2398 EG.5.1.1 > C5812T > G22927T(**S:L455F**) > A26565C(M:K15Q), C28770G(N:T166R)
- [ ] [Branch 31](#branch_31): Transferred to cov-lineages/pango-designation#2321 , follows EG.5.1.1 > C12020T(ORF1a:L3919F), T24496C > C2232T(ORF1a:A656V), C21516T, G22927T(**S:L455F**)
- [ ] [Branch 32](#branch_32): EG.5.1.1 > T4579A > G2329A, A8443G > G22927T(**S:L455F**) [Query: `T4579A, A8443G, G22927T`, 73 seqs, 01/17]
- [x] [Branch 33](#branch_33): Designated as **EG.5.1.19** after transferred to cov-lineages/pango-designation#2322 , phylogenetic order follows EG.5.1 > T26171A(ORF3a:M260K) > A17615G(ORF1b:K1383R), G22927T(**S:L455F**)
- [ ] [Branch 34](#branch_34): ~~EG.5.1.3 > G2946A(ORF1a:G894D), T15264C, T22926C(**S:L455S**) [Query: `C1889T, C2334T, T22926C, -A4340G, -A10703C`, 12 seqs, 01/03]~~ Slow
- [ ] [Branch 35](#branch_35): Transferred to cov-lineages/pango-designation#2354 EG.5.1.4 > C26111T(ORF3:P240L) > C18555T > T17268C > G22927T(**S:L455F**)
- [ ] [Branch 36](#branch_36): Transferred to cov-lineages/pango-designation#2399 EG.5.1.1 > C22388T > C1853T, G22927T(**S:L455F**)
- [ ] [Branch 37](#branch_37): ~~EG.5.1.1 > C29095T > G22927T(**S:L455F**)~~ `C29095T` became homoplastic across the EG.5.1+L455F tree, no longer tracking.
- [ ] [Branch 38](#branch_38): EG.5.1.1 > T24583C > G22927T(**S:L455F**) [Query: `C6541T, G22927T, T24583C`, 47 seqs, 01/19]
- [ ] [Branch 39](#branch_39): Designated as **HK.1.1** and retracted , Phylogenetic order follows: HK.1 (EG.5.1.1.1) > G22927T(**S:L455F**) [Query: `C6541T, G13627A, G22332, G22927T`, 132 seqs, 01/19] this query already included further mutated `S:G257D`
- [ ] [Branch 40](#branch_40): EG.5.1.1 > C10615T > G22927T(**S:L455F**) > C1426T, G25691T(ORF3a:G100V) [Query: `C1426T, C10615T , G22927T`, 48 seqs, 01/19]
- [ ] [Branch 41](#branch_41): ~~EG.5.1.1 > C24023T > C2485T, G15025A(ORF1b:A520T), G22927C(**S:L455F**) [Query: `C6541T, G22927C, C24023T`, 15 seqs, 01/17]~~ Slow
- [ ] [Branch 42](#branch_42): Transferred to cov-lineages/pango-designation#2355 EG.5.1.1 > C22687T > G22927T(**S:L455F**)
- [ ] [Branch 43](#branch_43): ~~EG.5.1.1 > C19524T > G22927T(**S:L455F**), A28254Δ~~ Seems pulled under HK.3, no longer tracking
- [x] [Branch 44](#branch_44): Designated with 3 levels: **EG.5.1.11**, **JR.1** and **JR.1.1**, Phylogenetic order follows: EG.5.1 > A22106C(**S:K182Q**) > C22995G(**S:T478R**), A25664G(ORF3a:Y91C) > C1613T(ORF1a:L450F), G20995T(ORF1b:G2510C), G22927C(**S:L455F**), A27388C
- [ ] [Branch 45](#branch_45): Transferred to cov-lineages/pango-designation#2308 EG.5.1.1 > C13968A, A15885G > T11449C > C10369T, G22927T(**S:L455F**), C29077T, G29140T(N:Q289H)
- [x] [Branch 46](#branch_46): Designated as **HK.22** via [cov-lineages/pango-designation@`2d3115a`](https://github.com/cov-lineages/pango-designation/commit/2d3115af565faf391755d033d9802bc717e3dd51) , phylogenetic order follows: EG.5.1.1 > G25407T(ORF3a:M5I) > C2662T > G22927T(**S:L455F**) > T15408C, T24709C > T2698C, A3019G, G18332A(ORF1b:R1622K), T22917A(**S:L452Q**) [Query: `C2662T, G22927T, G25407T`]
- [ ] [Branch 47](#branch_47): EG.5.1.1 > C7600T > G22927T(**S:L455F**) > T10216C [Query: `C7600T, T10216C, G22927T`, 52 seqs, 01/15]
- [ ] [Branch 48](#branch_48): Transferred to cov-lineages/pango-designation#2360 EG.5.1.1 > A23539T > G22927T(**S:L455F**) ⚠️ Please check potential misplacement.
- [ ] [Branch 49](#branch_49): ~~EG.5.1.4 > C8407T, C11008A(ORF1a:H3581Q), G22927T(**S:L455F**), G25538T(ORF3a:G49V), C25572T [Query: `A18492G, A21137G, G22927T, -C6120T, -G13627A, -C26111T`, 76 seqs, 01/20]~~ Now at least 3 smaller clusters seems pulled together a `S:L455F` branch right under EG.5.1.4 polytomy, hard to catch by proper query now.
- [ ] [Branch 50](#branch_50): ~~EG.5.1.1 > G28904T(N:A211S) > G22927T(**S:L455F**), G27261T, C28744T [Query: `C6541T, G22927T, G28904T`, 27 seqs, 01/19]~~ Slow
- [ ] [Branch 51](#branch_51): Transferred to cov-lineages/pango-designation#2365 EG.5.1.1 > C10015T > G22927T(**S:L455F**)
- [ ] [Branch 53](#branch_53): Transferred to cov-lineages/pango-designation#2366 EG.5.1.1 > C27741T > C1912T, C1968T(ORF1a:T568I), T7111C, A20010T(ORF1b:Q2181H), T20592C, G22927C(**S:L455F**), C28093T(ORF8:S67F)
- [ ] [Branch 54](#branch_54): EG.5.1.1 > G24368T(**S:D936Y**) > G22927T(**S:L455F**) [Query: `G13627A, G22927T, G24368T, -G3567A, -C4012T, -C5031T, -T13234C, -C17976T`, 72 seqs, 01/19]
- [x] [Branch 55](#branch_55): Designated with 2 levels: **HK.24** and **HK.24.1** , phylogenetic order follows EG.5.1.1 > G23522A(**S:E654K**) > G22927T(**S:L455F**)
- [ ] [Branch 56](#branch_56): EG.5.1.1 > A22582G > G22927T(**S:L455F**) [Query: `G13627A, A22582G, G22927T, -G3153A`, 39 seqs, 01/16]
- [ ] [Branch 57](#branch_57): EG.5.1.1 > A22582G > G3153A(ORF1a:G963D) > G22927T(**S:L455F**) [Query: `G3153A, A22582G, G22927T`, 57 seqs, 01/17]
- [ ] [Branch 58](#branch_58): EG.5.1 > T26972C > C28909T > C2106A(ORF1a:T614N), G28423T(ORF9b:R47L) > A21759G(**S:H66R**), G22927T(**S:L455F**), G24004A, C25572T [Query: `A18492G, G22927T, C28909T`, 46 seqs, 01/19]
- [ ] [Branch 59](#branch_59): EG.5.1.1 > G20134T(ORF1b:V2223L) > G22927T(**S:L455F**) [Query: `G13627A, G20134T, G22927T`, 46 seqs, 01/18] ⚠️ Please check potential reversion/artifact/misplacement
- [ ] [Branch 60](#branch_60): EG.5.1.1 > T16545G > C1471T, G22927T(**S:L455F**) [Query: `G13627A, T16545G, G22927T`, 67 seqs, 01/19]
- [ ] [Branch 62](#branch_62): ~~EG.5.1.1 > C18559T(ORF1b:L1698F) > T15927C, G22927T(**S:L455F**) [Query: `C6541T, C18559T, G22927T`, 16 seqs, 01/16]~~ Slow
- [ ] [Branch 63](#branch_63): Transferred to cov-lineages/pango-designation#2400 EG.5.1.1 > T14034C > T6556C, G22927T(**S:L455F**) ⚠️ Please check potential misplacement
- [ ] [Branch 64](#branch_64): EG.5.1.6 > C28236T(ORF8:R115C) > C16092T > C10969T > G526T(ORF1a:E87D) > C23380T > A12485G(ORF1a:I4074V) > T877C, A15270T(ORF1b:E601D), G22927T(**S:L455F**) [Query: `G526T, A15270T, G22927T`, 35 seqs, 01/19], thanks to @aviczhl2 and @FedeGueli
- [ ] [Branch 65](#branch_65): EG.5.1 > A3210G(ORF1a:D982G) > G26888A >G26227T, C28720T > T8909C> G22927T(**S:L455F**) [Query: `A3210G, T8909C, G22927T`, 25 seqs, 01/19]
- [ ] [Branch 66](#branch_66): EG.5.1.1 > C11779T > C12525T(ORF1a:T4087I) > G22927T(**S:L455F**) [Query: `C11779T, C12525T, G22927T`, 45 seqs, 01/19]
- [ ] [Branch 67](#branch_67): EG.5.1.1 > C25613T(ORF3a:S74F) > G22927C(**S:L455F**) [Query: `C6541T, G22927C, C25613T, -C26681T, -G26840A`, 51 seqs, 01/16]
- [ ] [Branch 68](#branch_68): EG.5.1.1 > G16710A > G22927T(**S:L455F**) [Query: `G16710A, G13627A, G22927T, -G28904T`, 72 seqs, 01/19]
- [ ] [Branch 69](#branch_69): EG.5.1.1 > G1085T(ORF1a:V274L) > G1535A(ORF1a:V424I), G22927T(**S:L455F**) [Query: `G1085T, G13627A, G22927T, -A11000G, -C29375T`, 69 seqs, 01/20]
- [ ] [Branch 70](#branch_70): EG.5.1.1 > T21748C > A16225G(ORF1b:T920A), T25036C > G22927C(**S:L455F**) [Query: `A16225G, T21748C, G22927C`, 42 seqs, 01/19]
- [ ] [Branch 71](#branch_71): EG.5.1.1 > C6638T(ORF1a:H2125Y) > G22927T(**S:L455F**) [Query: `C6638T, G13627A, G22927T, -C14889T`, 28 seqs, 01/19]
- [ ] [Branch 72](#branch_72): EG.5.1.1 > C11779T > G10261A > C9611T(ORF1a:L3116F), C18348T > G22927T(**S:L455F**) [Query: `C9611T, C11779T, G22927T`, 47 vseqs, 01/19]
- [ ] [Branch 73](#branch_73): HK.28 (C19170T) > G22927T(**S:L455F**) [Query: `G13627A, C19170T, G22927T, -C1909T, -C3736T, -C5031T, -C7504T, -A18153G`, 57 seqs, 01/19]
- [ ] [Branch 74](#branch_74): ~~EG.5.1.3 > A28032G(ORF8:I47V) > A1047C(ORF1a:K261T) > C3608A(ORF1a:L1115I), C18261T, G22927T(S:L455F) [Query: `A1047C, C1889T, G22927T`, 6 seqs, 11/22]~~ dead
- [ ] [Branch 75](#branch_75): EG.5.1.1 > C29253T(N:S327L) > G22927T(**S:L455F**) [Query: `G13627A, G22927T, C29253T, -G1067T, -C2110T, -A2730C`, 38 seqs, 01/19] ⚠️ Please check potential misplacement
- [ ] [Branch 76](#branch_76): HK.30 (EG.5.1.1 + T26609C) > C5907T(ORF1a:T1881I), T17454A > G22927T(**S:L455F**) [Query: `G13627A, G22927T, T26609C, -C24616T`, 40 seqs, 01/16]
- [x] [Branch 77](#branch_77): Designated **HV.2** after transferred to cov-lineages/pango-designation#2401 EG.5.1.6 > C925T, C27161T > C14919A > G14559A > G22927T(**S:L455F**)
- [ ] [Branch 78](#branch_78): EG.5.1.1 > C18395T(ORF1b:A1643V) > G22927T(**S:L455F**) [Query: `C6541T, C18395T, G22927T`, 47 seqs, 01/16]
- [ ] [Branch 79](#branch_79): ~~EG.5.1.1 > T6736C > T23287C > C22075T > C8389T, A16668G, C17474T(ORF1b:T1336I), G22927T(S:L455F), G26416T(E:V58F) [Query: `T6736C, G13627A, G22927T`, 16 seqs, 01/04] (Mostly with `S:Q14H/G21604C`)~~ Slow
- [ ] [Branch 80](#branch_80): EG.5.1.1 > C8146T > G2035A, G6373T(ORF1a:M2036I), G22927T(**S:L455F**) [Query: `C8146T, G13627A, G22927T, -C27557T`, 19 seqs, 01/17]
- [ ] [Branch 81](#branch_81): EG.5.1.1 > C2857T > G22927T(**S:L455F**) [Query: `C2857T, G13627A, G22927T, -C5031T, -T17475C`, 50 seqs, 01/19]
- [ ] [Branch 82](#branch_82): EG.5.1.1 > T16494C, T22307C > G22927C(**S:L455F**) [Query: `G13627A, T16494C, G22927C`, 18 seqs, 01/17]
- [ ] [Branch 83](#branch_83): EG.5.1.1 > C29358T(N:T362I) > T23803C > C842T(ORF1a:P193S), C15141T, T16743C, C22450T, G22927T(**S:L455F**), C24442T, C25916T(ORF3a:T175I), C28232T [Query: `G22927T, T23803C, C29358T`, 28 seqs, 01/10], thanks to @aviczhl2
- [ ] [Branch 84](#branch_84): HK.19 > C2455T > G22927T(**S:L455F**), C23533T [Query: `C2455T, C22033A, G22927T, -G25606A`, 20 seqs, 01/19]
- [ ] [Branch 85](#branch_85): EG.5.1.1 > C7390T > G22927T(**S:L455F**) [Query: `C7390T, G13627A, G22927T`, 49 seqs, 01/15] Mostly with `ORF6:N34K/C27303A`
- [ ] [Branch 86](#branch_86): EG.5.1.1 > G25855T(ORF3a:D155Y) > G22927T(**S:L455F**) > T4063C, C13405T, A21612C(**S:N17T**) [Query: `A21612C, G22927T, G25855T`, 79 seqs, 01/29]
- [ ] [Branch 87](#branch_87): EG.5.1 > C15960T > C16260T > G22927T(**S:L455F**), C24771T(**S:A1070V**), C25658T(ORF3a:T89I) [Query: `C15960T, C16260T, A18492G, G22927T`, 19 seqs, 01/19]
- [ ] [Branch 88](#branch_88): EG.5.1.1 > T4579A > A4576T > G22927T(**S:L455F**), [Query: `A4576T, G13627A, G22927T`, 118 seqs, 01/29] (Sibling to **Branch 32**)
- [ ] [Branch 89](#branch_89): EG.5.1.1 > C27406T(ORF7a:L5F) > G22927T(**S:L455F**) [Query: `C6541T, G13627A , G22927T, C27406T`, 11 seqs, 01/08]
- [ ] [Branch 90](#branch_90): EG.5.1.1 > C13724T(ORF1a:A4487V), A25636T(ORF3a:N82Y) > T10750C, G22927T(**S:L455F**) [Query: `G13627A, C13724T, G22927T, -C5031T`, 28 seqs, 01/12]
- [ ] [Branch 91](#branch_91): EG.5.1.1 > C22987T >G22927T(**S:L455F**) > G19419A, G21974C(**S:D138H**) [Query: `G13627A, G19419A, G21974C`, 12 seq, 12/26]
- [ ] [Branch 92](#branch_92): EG.5.1.1 > C629T(ORF1a:L122F) > A1168G > C22987T > T595C, C20148T, G22927T(**S:L455F**) [Query: `A1168G, G22927T, C22987T`, 11 seqs, 01/09]
- [ ] [Branch 93](#branch_93): ~~EG.5.1.18 > T1216C, A9034G, A12121T, A12519G(ORF1a:D4085G), G22927T(**S:L455F**) [Query: `G9269A, G22927T, G26051T`, 8 seqs, 12/19]~~ Slow
- [ ] [Branch 94](#branch_94): EG.5.1.13 > _G670T_rev(ORF1a:R135S_rev)_ > T28861C > G8889A(ORF1a:R2875H) > C13381T > G22424T(**S:A288S**) > C25047T(**S:P1162L**) > G25855T(ORF3a:D155Y) > G22927T(**S:L455F**) [Query: `G8889A, C13381T, G22927T`, 49 seqs, 01/15], a sub-branch of #1074 proposed by @aviczhl2
- [x] Designated with 2 levels: **HK.27** and **HK.27.1** from cov-lineages/pango-designation#2226 proposed by @FedeGueli , phylogenetic order follows: EG.5.1.1 > C5031T(ORF1a:T1589I) > `G22927T`(**S:L455F**) [Query: `C5031T, G22927T`]
- [x] Designated as **HK.1.2** via [cov-lineages/pango-designation@`2ee937c`](https://github.com/cov-lineages/pango-designation/commit/2ee937ccb13e3ee615171bdf04dde0ebf453807a) , formerly doublet, now proposed by @aviczhl2 : cov-lineages/pango-designation#2310 , Phylogenetic order follows: HK.1 (EG.5.1.1.1) > G6320A(ORF1a:V2019I) > C11704T, C22482T(**S:T307I**), G22927C(**S:L455F**) [Query: `G6320A, G22332T, G22927C`]
- [x] Designated as **JJ.1 (EG.5.1.4.1)** via [cov-lineages/pango-designation@`36e3fb0`](https://github.com/cov-lineages/pango-designation/commit/36e3fb099782e00f74e2ea4d9843cebe5aa48b60) , cov-lineages/pango-designation#2208 formerly a singlet, proposed by @aviczhl2 , Phylogenetic order follows: EG.5.1.4 > C26111T(ORF3:P240L) > G22927T(**S:L455F**), A25531G(ORF3a:I47V) [Query: `A21137G, G22927T, A25531G`]
- [x] Designated as **JG.3 (EG.5.1.3.3)** via [cov-lineages/pango-designation@`b084562`](https://github.com/cov-lineages/pango-designation/commit/b084562b0354573bcca5b27064caa06cdf04982c), proposed by @aviczhl2 , cov-lineages/pango-designation#2231 Phylogenetic order follows: EG.5.1.3 > C7086T(ORF1a:T2274I), G22927T(**S:L455F**), C23673T(**S:S704L**) [Query: `C1889T, G22927T, C23673T`]
- [ ] cov-lineages/pango-designation#2434 proposed by @aviczhl2 , Phylogenetic order follows: **EG.5.1.1** >T14988C, A23014T(S:A484A) > C1471T > C12823T > G25459T(ORF3a:A23S) > G22927T(**S:L455F**), ins28214T [Query: `C1471T, T14988C, G22927T`, 89 seqs, 01/19]
- [x] HK.3 (EG.5.1.1.3) designated via [cov-lineages/pango-designation@`39a35ba`](https://github.com/cov-lineages/pango-designation/commit/39a35ba57d785e6bdda763fd612b9d7ba4442119) , Phylogenetic order follows: EG.5.1.1 > `G22927T`(**S:L455F**)

Branch 1:

Transferred to main repo. Designated as HK.8 **Designated as HK.8 (EG.5.1.1.8) via cov-lineages/pango-designation@9527e15** _Transferred to cov-lineages/pango-designation#2230_ **Defining Mutations:** `EG.5.1.1` > `C11779T` > `G22927T(S:L455F)` **Query:** `C6541T, C11779T, G22927T` **Earliest seq:** 2023-06-27 (`EPI_ISL_18060870`, Yibin, Sichuan, China) **Latest seq:** 2023-07-17 (`EPI_ISL_18060877`, Zi'yang, Sichuan, China) **Sampled Countries:** China (2, Sichuan)
Genomes: `EPI_ISL_18060870, EPI_ISL_18060877`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_202eb_c2cf60.json?f_userOrOld=uploaded%20sample ![Branch1](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/45712d3a-99c1-444f-90a5-d54903ff70dc)

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Branch 2:

Transferred to main repo: _Transferred to cov-lineages/pango-designation#2229_ **Defining Mutations:** `EG.5.1.1` > `C12053T(ORF1a:L3930F)` > `C503T(ORF1a:P80S)` > `C7732T, C18175T(ORF1b:P1570S), G22927T(S:L455F)` **Query:** `C503T, C6541T, G22927T` **Earliest seq:** 2023-07-15 (`EPI_ISL_18060497`, Tokyo, Japan) **Latest seq:** 2023-07-18 (`EPI_ISL_18065046`, Miyagi, Japan) **Sampled Countries:** Japan (2)
Genomes: `EPI_ISL_18060497, EPI_ISL_18065046`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_22c78_c2e570.json?f_userOrOld=uploaded%20sample ![Branch2](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/9b39313e-98f9-4892-a3d8-48effc0f6abe)

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Branch 3

Transferred to main repo _Transferred to cov-lineages/pango-designation#2194_ **Defining Mutations:** `EG.5.1.1` > `C11779T` > `C6781T, C17802T, G22927C(S:L455F)` **Query:** `C6781T, C17802T, G22927C` **Earliest seq:** 2023-07-04 (`EPI_ISL_17994488`, Shanghai, China) **Latest seq:** 2023-07-18 (`EPI_ISL_18074754`, Shanghai, China) **Sampled Countries:** China (3, Shanghai)
Genomes: `EPI_ISL_17994488, EPI_ISL_18074751, EPI_ISL_18074754`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_13292_36d050.json?f_userOrOld=uploaded%20sample ![Branch3](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/40e19529-9315-4dc4-aa04-126e4e38e0f8)

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Branch 4

Transferred to main repo Transferred to cov-lineages/pango-designation#2224 **Defining Mutations:** `EG.5.1` > `C12100G, G22927T`(**S:L455F**) **Query:** `C12100G, G22927T` **Earliest seq:** 2023-07-09 (`EPI_ISL_18060822`, Shanghai, China) **Latest seq:** 2023-07-31 (`EPI_ISL_18094969`, Washington, USA with Travel History to: Japan) **Sampled Countries:** China (2, Shanghai, 1 ex. Thailand), USA (2, Washington, ex. Japan)
Genomes: `EPI_ISL_18060822, EPI_ISL_18075026, EPI_ISL_18094946, EPI_ISL_18094969`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_1ebd2_7501c0.json?f_userOrOld=uploaded%20sample&label=id:node_6794320 ![Branch4](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/09a0e977-4ba2-47a4-9f39-728b807afd46)

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Branch 5

Transferred to main repo _Transferred to cov-lineages/pango-designation#2250_ **Defining Mutations:** `EG.5.1.1` > `G22927C`(**S:L455F**, different to **HK.3**'s `G22927T`) **Query:** `C6541T, G22927C, -C3653T, -C6317T, -C6327T, -A6659G, -T7111C, -C8074T, -G8768A, -C10702T, -C11779T, -C13968A, -T17811C, -A21137G, -T21748C, -C22482T, -C24023T, -C27741T, -G29734T` **Earliest seq:** 2023-07-08 (`EPI_ISL_18012368`, Sichuan, China) **Latest seq:** 2023-07-27 (`EPI_ISL_18105834`, Shanghai, China) **Sampled Countries:** China (3: Shanghai/2; Sichuan/1)
Genomes: `EPI_ISL_18012368, EPI_ISL_18074450, EPI_ISL_18105834`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_a8d5_ccb160.json?branchLabel=nuc%20mutations&f_userOrOld=uploaded%20sample&label=id:node_6794516 ![Branch5](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/7121e114-52de-42ff-88d3-2a565bee4f43)

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Branch 6

Many sequences pulled back to HK.3, the reversion probably due to dropout rather than recombinant **Defining Mutations:** `EG.5.1.1` > _T22480C_Reversion_ > `G22927T`(**S:L455F**) **Query:** `C6541T, G13627A, G22927T, -C7948T, -C22480T` **Earliest seq:** 2023-07-05 (`EPI_ISL_17988079`, Xiangyang, Hubei) **Latest seq:** 2023-08-07 (`EPI_ISL_18105560`, Xiangyang, Hubei) **Sampled Countries:** China (4, Hubei)
Genomes: `EPI_ISL_17988079, EPI_ISL_18105559-18105560, EPI_ISL_18105562`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_100ff_ccdc70.json?f_userOrOld=uploaded%20sample&label=id:node_6791410 ![Branch6](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/0e84c4f9-ccf6-431b-85be-02749568d1e8)

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Branch 7

Defining Mutations: EG.5.1.1 > C6627T(ORF1a:T2121I) > T17147C(ORF1b:I1227T) > G22927T(S:L455F) Query: C6627T, T17147C, G22927T Earliest seq: 2023-07-06 (EPI_ISL_18074610, Shanghai) Latest seq: 2023-08-05 (EPI_ISL_18108436, Shanghai, Travel history: Singapore) Sampled Countries: China (3: Shanghai)

Genomes: `EPI_ISL_18074610, EPI_ISL_18108436, EPI_ISL_18108490`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_1999b_eabba0.json?f_userOrOld=uploaded%20sample&label=id:node_10741278 Branch7

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Branch 8

Defining Mutations: EG.5.1.1 > C5284T > T14655C > C15951T, G22927T(S:L455F) Query: C5284T, T14655C, G22927T Earliest seq: 2023-07-23 (EPI_ISL_18105571, Shanghai) Latest seq: 2023-08-11 (EPI_ISL_18114886, Shanghai) Sampled Countries: China (3, Shanghai)

Genomes: `EPI_ISL_18105571, EPI_ISL_18108625, EPI_ISL_18114886`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_28a92_b9eb0.json?f_userOrOld=uploaded%20sample&label=id:node_6895881 Branch8

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Branch 9

Defining Mutations: EG.5.1.1 > C19983T > G22927T(S:L455F) Query: C6541T, G13627A, C19983T, G22927T, -C6695T **Earliest seq:** 2023-06-30 (EPI_ISL_18074254, Liaoning, China) **Latest seq:** 2023-08-27 (EPI_ISL_18239976`, Utah, USA) Sampled Countries: China (3: Liaoning/2; Shanghai/1)

Genomes: `EPI_ISL_18074249, EPI_ISL_18074254`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_2cc80_bc030.json?f_userOrOld=uploaded%20sample&label=id:node_6895986 Branch9

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Branch 10

Transferred to main repo _Transferred to cov-lineages/pango-designation#2251_ **Defining Mutations:** EG.5.1.1 > C11173T > G22927T(**S:L455F**) **Query:** `C11173T, G13627A, G22927T, -T22228C, -C27406T, -T28157C` **Earliest seq:** 2023-07-16 (`EPI_ISL_18049850`, Qinghai) **Latest seq:** 2023-08-01 (`EPI_ISL_18114762`, Shanghai) **Sampled Countries:** China (3, Qinghai, Shanghai, Xinjiang)
Genomes: `EPI_ISL_18049850, EPI_ISL_18108872, EPI_ISL_18114762`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_33d9d_bf590.json?f_userOrOld=uploaded%20sample&label=id:node_10744521 ![Branch10](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/812b2eab-80c7-41a0-b88e-c829a85b3569)

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Branch 11

Defining Mutations: EG.5.1 > C9430T > T1939C, C10039T, C20873G(ORF1b:A2469G), G22927T(S:L455F) Query: C9430T, G21718T, G22927T, -C1889T, -G13627A, -C21622A Earliest seq: 2023-07-31 (EPI_ISL_18127303, Tokyo, Japan) Latest seq: 2023-08-07 (EPI_ISL_18127606, Kanagawa, Japan) Sampled Countries: Japan (3: Tokyo/2; Kanagawa/1)

Genomes: `EPI_ISL_18127215, EPI_ISL_18127303, EPI_ISL_18127606`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice4_genome_1293d_792f00.json?f_userOrOld=uploaded%20sample Branch11

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Branch 12:

Designated EG.5.1.17 _Designated as **EG.5.1.17** via cov-lineages/pango-designation@5a8103c_ **Defining Mutations:** `EG.5.1` > `G22927C(S:L455F)` **Query:** `C2334T, A18492G, G22927C, -G1069A, -A22106C, -C22570T, -C25572T` **Earliest seq:** 2023-07-09 (`EPI_ISL_18108295`, Anhui, China) **Latest seq:** 2023-08-15 (`EPI_ISL_18138165`, Shanghai, China) **Sampled Countries:** China (4: Shanghai/3; Anhui/1)
Genomes: `EPI_ISL_18108295, EPI_ISL_18114797, EPI_ISL_18138165, EPI_ISL_18138282`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_289ba_a2e580.json?f_userOrOld=uploaded%20sample&label=id:node_6920519 ![Branch12](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/265b77e9-fb98-487a-ae1a-fe2014bed801)

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Branch 13:

Transferred to main repo _transferred to cov-lineages/pango-designation#2364_ **Defining Mutations:** `EG.5.1.1` > `C19011T` > `C8991T(ORF1a:A2909V)` > `G22927T(S:L455F)` **Query:** `C8991T, C19011T, G22927T` **Earliest seq:** 2023-08-14 (`EPI_ISL_18146054`, Hubei, China) **Latest seq:** 2023-10-31 (`EPI_ISL_18473645`, Singapore, travel history: India) **Sampled Countries:** China (38: HB/23; SH/4; AH/3; BJ/2; YN/2; GS/1; HA/1; QH/1; XJ/1), Singapore (5: Local/2; ex. China/2; ex. India/1), Netherlands (3), Australia (2: NSW), Austria (1), Croatia (1), France (1), Laos (1)
Genomes: `EPI_ISL_18141179, EPI_ISL_18146054, EPI_ISL_18146087, EPI_ISL_18217222, EPI_ISL_18217236, EPI_ISL_18254205, EPI_ISL_18268148-18268149, EPI_ISL_18268153, EPI_ISL_18268244, EPI_ISL_18284712, EPI_ISL_18284755, EPI_ISL_18306934, EPI_ISL_18313098, EPI_ISL_18313105, EPI_ISL_18313198, EPI_ISL_18313226, EPI_ISL_18349877, EPI_ISL_18354962, EPI_ISL_18363349, EPI_ISL_18376465, EPI_ISL_18376494, EPI_ISL_18384477, EPI_ISL_18384508, EPI_ISL_18388887, EPI_ISL_18388889, EPI_ISL_18388891, EPI_ISL_18438085, EPI_ISL_18438311, EPI_ISL_18438356, EPI_ISL_18438359, EPI_ISL_18438427, EPI_ISL_18441693, EPI_ISL_18442727, EPI_ISL_18442730, EPI_ISL_18447747, EPI_ISL_18457659, EPI_ISL_18461703, EPI_ISL_18461971, EPI_ISL_18463327, EPI_ISL_18463426, EPI_ISL_18464919, EPI_ISL_18464984, EPI_ISL_18465193, EPI_ISL_18465381, EPI_ISL_18465391, EPI_ISL_18466345, EPI_ISL_18473414, EPI_ISL_18473645, EPI_ISL_18475163, EPI_ISL_18475178`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_16441_b42970.json?label=id:node_3500994 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/6656c336-7805-4491-8fc0-8072605bf90a)

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Branch 14

Defining Mutations: EG.5.1.1 > A8443G > G22927T(S:L455F) Query: C6541T, A8443G, G22927T Earliest seq: 2023-07-22 (EPI_ISL_18060879 Ziyang, Sichuan) Latest seq: 2023-08-09 (EPI_ISL_18146071, Xiaogan, Hubei) Sampled Countries: China (3: Sichuan/2; Hubei/1)

Genomes: `EPI_ISL_18060879, EPI_ISL_18146071, EPI_ISL_18166195`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_140e3_db750.json?f_userOrOld=uploaded%20sample Branch14

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Branch 15

Designated with levels: HK.23, HK.23.1 and HK.23.1.1 Designated as three levels: [HK.23](https://github.com/cov-lineages/pango-designation/commit/12691b30210c9ab9b68ebfe04bda957d9a09b806), [HK.23.1](https://github.com/cov-lineages/pango-designation/commit/b83d9aa28a32b8a70a6e049b29986577cf07f23a) and [HK.23.1.1](https://github.com/cov-lineages/pango-designation/commit/b47c3ca2d6369c236951efde3b954e9ac022e5b7) _Transferred to cov-lineages/pango-designation#2340_ **Defining Mutations:** `EG.5.1.1` > `C28087T(ORF8:A65V)` > `G22927T(S:L455F)` **Query:** `C6541T, G22927T, C28087T, -A4306G, -G4444A, -A6889G, -G8171A, -T8305C, -C10039T, -C19185T, -C25207T` **Earliest seq:** 2023-08-10 (`EPI_ISL_18138246`, Shanghai) **Latest seq:** 2023-08-14 (`EPI_ISL_18208534`, Shanghai) **Sampled Countries:** China (3: Shanghai)
Genomes: `EPI_ISL_18138040, EPI_ISL_18138246, EPI_ISL_18208534`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_192a8_20dc90.json?f_userOrOld=uploaded%20sample ![Branch15](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/bf26d8a6-4591-49a8-a8e4-1dba0e1f51de)

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Branch 16

Defining Mutations: EG.5.1.1 > C8074T > T17811C > C7604T, C10789T, C10834T, C12815T, G20348T(ORF1b:S2294I), G22927C(S:L455F), A25998G Query: C6541T, C8074T, G22927C Earliest seq: 2023-08-22 (EPI_ISL_18217203, Hubei, China) Latest seq: 2023-08-22 (EPI_ISL_18217204, Hubei, China) Sampled Countries: China (3)

Genomes: `EPI_ISL_18217202-18217204`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_1c2cf_6feba0.json?c=gt-S_455&gmax=25384&gmin=21563&label=id:node_6949824 Branch16

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Branch 17

Transferred to main repo _Transferred to cov-lineages/pango-designation#2341_ **Defining Mutations:** `EG.5.1.1` > `C9118T` > `G22927T(S:L455F)` **Query:** `C6541T, C9118T, G22927T, -C25546A` **Earliest seq:** 2023-08-14 (`EPI_ISL_18214798`, Osaka, Japan) **Latest seq:** 2023-10-02 (`EPI_ISL_18373543`, England, UK) **Sampled Countries:** Japan (37), USA (4: TX/2; NJ; SC), South Korea (2), UK (2: EN), Australia (1: WA), Canada (1: ON), France (1)
Genomes: `EPI_ISL_18162837, EPI_ISL_18166739, EPI_ISL_18214798, EPI_ISL_18214838, EPI_ISL_18226559, EPI_ISL_18235760, EPI_ISL_18236014, EPI_ISL_18242568, EPI_ISL_18243896, EPI_ISL_18247826-18247827, EPI_ISL_18253490, EPI_ISL_18261506, EPI_ISL_18271898, EPI_ISL_18279175, EPI_ISL_18279234, EPI_ISL_18285272, EPI_ISL_18285440, EPI_ISL_18294200, EPI_ISL_18300272, EPI_ISL_18338985, EPI_ISL_18342460, EPI_ISL_18354762, EPI_ISL_18354776, EPI_ISL_18362312, EPI_ISL_18370698, EPI_ISL_18370761, EPI_ISL_18371874, EPI_ISL_18372806, EPI_ISL_18373146, EPI_ISL_18373543, EPI_ISL_18376280, EPI_ISL_18376286, EPI_ISL_18377931, EPI_ISL_18382356, EPI_ISL_18382437, EPI_ISL_18382737, EPI_ISL_18385259, EPI_ISL_18387636, EPI_ISL_18390707, EPI_ISL_18390782, EPI_ISL_18390836, EPI_ISL_18397002, EPI_ISL_18402105, EPI_ISL_18402112, EPI_ISL_18411313, EPI_ISL_18413797, EPI_ISL_18413896`
**UShER:** https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_1f50e_2e6ab0.json?f_userOrOld=uploaded%20sample&label=id:node_3461917 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/9bf07613-bbac-4302-90a2-578ca67c3648)

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Branch 18

Merged into HK.3 **Defining Mutations:** `EG.5.1.1` > `C22264T` > `G22927T(S:L455F)` **Query:** `G13627A, C22264T, G22927T` **Earliest seq:** 2023-07-30 (`EPI_ISL_18129236`, British Columbia, Canada) **Latest seq:** 2023-08-28 (`EPI_ISL_18213253`, Fujian, China) **Sampled Countries:** Canada (1, BC), China (1, Fujian), UK (1, England)
Genomes: `EPI_ISL_18129236, EPI_ISL_18142517, EPI_ISL_18213253`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_2fbb2_705f80.json?c=gt-nuc_22264&gmax=23264&gmin=21264&label=id:node_6943899 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/0b91a73e-5147-4ac7-a21e-048eeb07efb0)

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Branch 19

Merged under HK.13, no longer tracking **Defining Mutations:** `EG.5.1.1` > `C29167T` > `G1186A, T4871C(ORF1a:Y1536H), C7011T(ORF1a:A2249V), G17741A(ORF1b:R1425H), G22927C(S:L455F)` **Query:** `T4871C, G17741A` **Earliest seq:** 2023-08-09 (`EPI_ISL_18160385`, New York, USA) **Latest seq:** 2023-08-19 (`EPI_ISL_18214905`, Ibaraki, Japan) **Sampled Countries:** China (1, Shanghai), Japan (1), USA (1, NY)
Genomes: `EPI_ISL_18160385, EPI_ISL_18208589, EPI_ISL_18214905`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_15b7_70e2f0.json?label=id:node_6948139 ![Branch19](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/0b622b0c-273c-4a0b-8b4a-2e1d8934f5e5)

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Branch 20

Designated as HK.33 _Designated as HK.33 via cov-lineages/pango-designation@7ad122e_ **Defining Mutations:** `EG.5.1.1` > `C2644T` > `T7957C, G22927T(S:L455F), G29348T(N:A359S)` **Query:** `C2644T, G13627A, G22927T` **Earliest seq:** 2023-08-21 (`EPI_ISL_18222131`, `SEA` airport, Washington, USA, travel history: UK) **Latest seq:** 2023-08-25 (`EPI_ISL_18208454`, Shanghai, China) **Sampled Countries:** USA (2, ex. UK), China (1, Shanghai)
Genomes: `EPI_ISL_18147035, EPI_ISL_18208454, EPI_ISL_18222131`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_172d3_85e8d0.json?f_userOrOld=uploaded%20sample&label=id:node_6951215 ![Branch20](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/477f1392-9f03-4288-82c4-0f61ab72f1ad)

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Branch 21, now pulled under HK.3.8

Pulled under HK.3.8 **Defining Mutations:** `EG.5.1.1` > `C18747T` > `C643T, T13060C, G19723T(ORF1b:V2086F), G22927T(S:L455F)` **Query:** `C643T, C18747T, G22927T` **Earliest seq:** 2023-08-11 (`EPI_ISL_18208543`, Shanghai) **Latest seq:** 2023-08-28 (`EPI_ISL_18232547`, Shanghai Customs, travel history to Japan **Sampled Countries:** China (3, SH)
Genomes: `EPI_ISL_18208543, EPI_ISL_18208548, EPI_ISL_18232547`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_1d67e_99d900.json?label=id:node_10811725 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/3c05a1f5-eb0c-4b18-8389-f5b9da65dab6)

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Branch 22, Now pulled under HK.3.2 > A708C(ORF1a:E148A) > C10969T, G23593T(S:Q677H), G28056A(ORF8:A55T), no longer tracking.

Pulled under HK.3.2 **Defining Mutations:** `HK.5` > `G22927T(S:L455F)` **Query:** `spike_Q52H, spike_L455F, spike_Q677H` **Earliest seq:** 2023-08-13 (`EPI_ISL_18146068`, Hubei) **Latest seq:** 2023-08-24 (`EPI_ISL_18226161`, Virginia) **Sampled Countries:** USA (2, VA), China (1, HB)
Genomes: `EPI_ISL_18146068, EPI_ISL_18226161-18226162`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_34c06_9a5d70.json?f_userOrOld=uploaded%20sample&label=id:node_10811724 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/e2f94f6f-d03f-49f5-bc6a-8238b685160d)

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Branch 23

Transferred to main repo: _Transferred to main repo cov-lineages/pango-designation#2319_ **Defining Mutations:** `HK.2` > `G22927T(S:L455F)` **Query:** `C6541T, G21604T, G22927T, -A518G, -C934T, -C1426T, -G3663A, -C5031T, -C7712T, -A7849G, -C8320T, -T16545G` **Earliest seq:** 2023-08-21 (`EPI_ISL_18141161`, Singapore) **Latest seq:** 2023-08-23 (`EPI_ISL_18232599`, Shanghai) **Sampled Countries:** Singapore (1), China (2, SH)
Genomes: `EPI_ISL_18141161, EPI_ISL_18232598-18232599`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_40e5c_9aa250.json?f_userOrOld=uploaded%20sample&label=id:node_10811725 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/77f25a80-600d-4b82-b157-89102858a070)

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Branch 24, Designated as HK.20 via cov-lineages/pango-designation@71cf97b ; follow-up S:G482R/G23006C designated as HK.20.1

Designated as HK.20 and HK.20.1 _Transferred to cov-lineages/pango-designation#2353_ **Defining Mutations:** `EG.5.1.1` > `C6695T(ORF1a:P2144S)` > `C9448A` > `C5575T, G22927T(S:L455F)` **Query:** `C6695T, C9448A, G22927T` **Earliest seq:** 2023-08-13 (`EPI_ISL_18114870`, Shanghai Customs, travel history to Japan) **Latest seq:** 2023-10-20 (`EPI_ISL_18448529`, Ontario, Canada) **Sampled Countries:** China (13, SH/6; SC/4; FJ/1; ex. Japan/1; ex. S. Korea/1), USA (12: CA/8; AZ/1; OH/1; TX/1; ex. Nepal/1), Singapore (6: Local/5; ex. China/1), Italy (5), UK (3: EN), Australia (2: NSW; QLD), Canada (2: ON), Japan (2), South Korea (2), Switzerland (2), Denmark (1), France (1), Spain (1)
Genomes: `EPI_ISL_18114870, EPI_ISL_18208555, EPI_ISL_18208592, EPI_ISL_18208601, EPI_ISL_18232643, EPI_ISL_18246292, EPI_ISL_18284706, EPI_ISL_18285031, EPI_ISL_18285192, EPI_ISL_18306956, EPI_ISL_18307066, EPI_ISL_18320793, EPI_ISL_18328004, EPI_ISL_18352555, EPI_ISL_18354001, EPI_ISL_18355023, EPI_ISL_18360344, EPI_ISL_18360616, EPI_ISL_18361723, EPI_ISL_18366403, EPI_ISL_18370066, EPI_ISL_18370200, EPI_ISL_18371411, EPI_ISL_18376528, EPI_ISL_18385607, EPI_ISL_18386446, EPI_ISL_18386489, EPI_ISL_18387133, EPI_ISL_18397207, EPI_ISL_18403093, EPI_ISL_18407761, EPI_ISL_18409112, EPI_ISL_18411495, EPI_ISL_18415804, EPI_ISL_18421982, EPI_ISL_18423702, EPI_ISL_18425050, EPI_ISL_18428715, EPI_ISL_18429030, EPI_ISL_18430106, EPI_ISL_18433978, EPI_ISL_18435244, EPI_ISL_18442967, EPI_ISL_18443714, EPI_ISL_18443742-18443744, EPI_ISL_18443746, EPI_ISL_18444154, EPI_ISL_18446641, EPI_ISL_18448416, EPI_ISL_18448529`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_11cc_c2b40.json?label=id:node_3485632 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/536ca3bf-307c-4008-9935-30f195bed8ac)

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Branch 25: Mostly with S:A684V

Defining Mutations: EG.5.1.1 > C29296T > G22927T(S:L455F) Query: C6541T, G22927T, C29296T Earliest seq: 2023-08-06 (EPI_ISL_18133933, Qinghai) Latest seq: 2023-08-30 (EPI_ISL_18245873, Gansu) Sampled Countries: China (4: SC/2; GS; QH)

Genomes: `EPI_ISL_18133933, EPI_ISL_18245873, EPI_ISL_18246316, EPI_ISL_18246328`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_fec3_1b4b0.json?label=id:node_10825408 image

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Branch 26

Transferred to main repo _Transferred to main repo cov-lineages/pango-designation#2320_ **Defining Mutations:** `HK.11` > `T13228C` > `T4789A` > `G22927T(S:L455F)` **Query:** `T4789A, T13228C, G22927T` **Earliest seq:** 2023-08-21 (`EPI_ISL_18221467`, Halland, Sweden) **Latest seq:** 2023-08-21 (`EPI_ISL_18244247`, Denmark) **Sampled Countries:** Denmark (2), Sweden (1)
Genomes: `EPI_ISL_18221467, EPI_ISL_18244233, EPI_ISL_18244247`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_1d161_22300.json?f_userOrOld=uploaded%20sample&label=id:node_6955887 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/8f89dd4e-c794-40a8-941f-91cb71dfa234)

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Branch 27

Transferred to main repo _Transferred to cov-lineages/pango-designation#2342_ **Defining Mutations:** `EG.5.1.1` > `C25493A(ORF3a:T34K)` > `G28884C(N:G204P)` > `G22927T(S:L455F)` **Query:** `C6541T, G22927T, C25493A` **Earliest seq:** 2023-07-18 (`EPI_ISL_18245992`, Heilongjiang) **Latest seq:** 2023-10-10 (`EPI_ISL_18397223`, Singapore) **Sampled Countries:** China (18: HL/10; LN/2; SH/2; HB; SC; SX; YN), Singapore (14), Denmark (4), Italy (3), USA (3: CA/2; NY), France (2), Australia (1: NSW), Germany (1), South Korea (1), Sweden (1)
Genomes: `EPI_ISL_18138073, EPI_ISL_18232576, EPI_ISL_18244264, EPI_ISL_18245964, EPI_ISL_18245971, EPI_ISL_18245992, EPI_ISL_18246139, EPI_ISL_18246193, EPI_ISL_18282065, EPI_ISL_18300796, EPI_ISL_18306948, EPI_ISL_18306976, EPI_ISL_18306993, EPI_ISL_18307005-18307006, EPI_ISL_18307019, EPI_ISL_18307026, EPI_ISL_18313136, EPI_ISL_18320696, EPI_ISL_18324230, EPI_ISL_18329168, EPI_ISL_18330265, EPI_ISL_18339790, EPI_ISL_18352920, EPI_ISL_18356975, EPI_ISL_18361976, EPI_ISL_18362045, EPI_ISL_18376532, EPI_ISL_18376955, EPI_ISL_18377536, EPI_ISL_18377636, EPI_ISL_18382895, EPI_ISL_18384393, EPI_ISL_18384413, EPI_ISL_18384418, EPI_ISL_18384426, EPI_ISL_18384448, EPI_ISL_18384625, EPI_ISL_18384643, EPI_ISL_18391206-18391207, EPI_ISL_18397223, EPI_ISL_18397241, EPI_ISL_18397267, EPI_ISL_18397584, EPI_ISL_18401938, EPI_ISL_18405209, EPI_ISL_18406218`
**UShER:** https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_58dd0_2eda30.json?f_userOrOld=uploaded%20sample&label=id:node_3458763 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/287e4c21-ad58-4ae8-8be9-f6b2b6b93270)

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Branch 28

Transferred to main repo: _Transferred to cov-lineages/pango-designation#2398_ **Defining Mutations:** **EG.5.1.1** > `C5812T` > `G22927T(S:L455F)`, mostly with >> `A26565C(M:K15Q), C28770G(N:T166R)` **Query:** `C5812T, G22927T, C28770G` (for major `A26565C(M:K15Q), C28770G(N:T166R)` sub-branch only) **Earliest seq:** 2023-08-09 (`EPI_ISL_18214077`, South Korea) **Latest seq:** 2023-11-09 (`EPI_ISL_18547984`, Nevada, USA) **Sampled Countries:** South Korea (68), USA (5: NV/2; NC/1; ex. S. Korea/2), Australia (2: NSW; QLD), China (2: SC/1; ex. S. Korea/1), Denmark (2), Hungary (2), Finland (1), Japan (1)
Genomes: `EPI_ISL_18214077, EPI_ISL_18236938, EPI_ISL_18293068, EPI_ISL_18293497, EPI_ISL_18347905, EPI_ISL_18353940, EPI_ISL_18354370, EPI_ISL_18354403, EPI_ISL_18355265, EPI_ISL_18355547, EPI_ISL_18368528, EPI_ISL_18382157, EPI_ISL_18382304, EPI_ISL_18382505, EPI_ISL_18382615, EPI_ISL_18386641, EPI_ISL_18408701-18408702, EPI_ISL_18408814, EPI_ISL_18408878, EPI_ISL_18411301, EPI_ISL_18415920, EPI_ISL_18435710, EPI_ISL_18438964, EPI_ISL_18439203, EPI_ISL_18439262-18439263, EPI_ISL_18439368, EPI_ISL_18439436, EPI_ISL_18460639, EPI_ISL_18460726, EPI_ISL_18460826, EPI_ISL_18461023, EPI_ISL_18461030, EPI_ISL_18461109, EPI_ISL_18461117, EPI_ISL_18461139, EPI_ISL_18488790, EPI_ISL_18488878, EPI_ISL_18488904, EPI_ISL_18489119, EPI_ISL_18501908, EPI_ISL_18502007, EPI_ISL_18503617, EPI_ISL_18503624, EPI_ISL_18503755, EPI_ISL_18503952, EPI_ISL_18503974, EPI_ISL_18511170, EPI_ISL_18511222, EPI_ISL_18511248, EPI_ISL_18511257, EPI_ISL_18511484, EPI_ISL_18513699, EPI_ISL_18518361, EPI_ISL_18535616, EPI_ISL_18535618, EPI_ISL_18535641, EPI_ISL_18535643-18535644, EPI_ISL_18535683, EPI_ISL_18539076, EPI_ISL_18539319, EPI_ISL_18539641, EPI_ISL_18539827, EPI_ISL_18540358, EPI_ISL_18544082, EPI_ISL_18547609, EPI_ISL_18547984, EPI_ISL_18550336, EPI_ISL_18552522, EPI_ISL_18559930, EPI_ISL_18564453, EPI_ISL_18564477, EPI_ISL_18564533, EPI_ISL_18564565, EPI_ISL_18564603, EPI_ISL_18564701, EPI_ISL_18564813, EPI_ISL_18564892, EPI_ISL_18564897, EPI_ISL_18565136`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_356f8_c1a890.json?label=id:node_3518019 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/4396addb-0170-4ef0-b401-e67de407edec)

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Branch 29

Now pulled under HK.3 **Defining Mutations:** **EG.5.1.1** > `C16726T(ORF1b:H1087Y)` > `G9424T, A12472G, G22927T(S:L455F), T23030C(**S:F490P**), G27621T(ORF7a:Q76H)` **Query:** `A12472G, G22927T, G27621T` **Earliest seq:** 2023-08-25 (`EPI_ISL_18245860`, Fujian, China) **Latest seq:** 2023-09-06 (`EPI_ISL_18243501`, Singapore) **Sampled Countries:** Singapore (2), China (1, FJ)
Genomes: `EPI_ISL_18243491, EPI_ISL_18243501, EPI_ISL_18245860`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_4007a_342f0.json?label=id:node_10825409 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/59683863-45b7-46a7-b315-5bbea3f6b722)

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Branch 30

Now pulled under HK.3 **Defining Mutations:** **EG.5.1.1** > `C4423T` > `G22927T(S:L455F)` **Query:** `C4423T, G13627A, G22927T` **Earliest seq:** 2023-08-12 (`EPI_ISL_18246284`, Sichuan, China) **Latest seq:** 2023-08-25 (`EPI_ISL_18235973`, Chiba, Japan) **Sampled Countries:** China (2, SC), Japan (1)
Genomes: `EPI_ISL_18232772, EPI_ISL_18235973, EPI_ISL_18246284`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_5299_39270.json?f_userOrOld=uploaded%20sample&label=id:node_6954721 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/195711be-284c-430e-bd45-05e4c2498c26)

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Branch 31

Transferred to main repo _Transferred to cov-lineages/pango-designation#2321_ **Defining Mutations:** **EG.5.1.1** > `C12020T(ORF1a:L3919F), T24496C` > `C2232T(ORF1a:A656V), C21516T, G22927T(S:L455F)` **Query:** `C6541T, C12020T, G22927T, -G6337T, -C8982A, -G18445A, -C28087T` **Earliest seq:** 2023-08-21 (`EPI_ISL_18216560`, Galway, Ireland) **Latest seq:** 2023-09-04 (`EPI_ISL_18254216`, Hubei) **Sampled Countries:** China (1), Ireland (1), UK (1)
Genomes: `EPI_ISL_18216560, EPI_ISL_18244531, EPI_ISL_18254216`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_203fd_1904a0.json?label=id:node_6967052 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/0d7177d2-65f0-4c89-b10e-f8bfa28477e8)

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Branch 32

Defining Mutations: EG.5.1.1 > T4579A > G2329A, A8443G > G22927T(S:L455F) Query: T4579A, A8443G, G22927T Earliest seq: 2023-08-08 (EPI_ISL_18166186, Sichuan) Latest seq: 2023-08-26 (EPI_ISL_18254268, Hubei) Sampled Countries: China (5)

Genomes: `EPI_ISL_18166186, EPI_ISL_18232746, EPI_ISL_18245861, EPI_ISL_18246325, EPI_ISL_18254268`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_647e_1a2900.json?label=id:node_6956460 image

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Branch 33

Designated as EG.5.1.19 _Designated as **EG.5.1.19** via cov-lineages/pango-designation@0807c23 , after transferred to cov-lineages/pango-designation#2322_ **Defining Mutations:** **EG.5.1** > `T26171A(ORF3a:M260K)` > `A17615G(ORF1b:K1383R), G22927T(S:L455F)` **Query:** `G21718T, G22927T, T26171A` **Earliest seq:** 2023-08-09 (`EPI_ISL_18134871`, Daknam, Belgium) **Latest seq:** 2023-09-03 (`EPI_ISL_18252041`, `SEA` airport, Washington, with travel hisotry: Netherlands) **Sampled Countries:** Belgium (1), France (1), Romania (1), USA (1, ex. Netherlands)
Genomes: `EPI_ISL_18134871, EPI_ISL_18229094, EPI_ISL_18252041, EPI_ISL_18254718`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_107fe_1a6cd0.json?f_userOrOld=uploaded%20sample&label=id:node_6953659 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/7d34dc4e-6940-4696-8973-a95864566e8a)

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Branch 34, NOT FLip but with S:L455S

Defining Mutations: EG.5.1.3 > G2946A(ORF1a:G894D), T15264C, T22926C(S:L455S) Query: C1889T, C2334T, T22926C, -A4340G, -A10703C Earliest seq: 2023-07-27 (EPI_ISL_18248425, Zagreb, Croatia) Latest seq: 2023-07-31 (EPI_ISL_18248430, Zagreb, Croatia) Sampled Countries: Croatia (4)

Genomes: `EPI_ISL_18248425, EPI_ISL_18248427, EPI_ISL_18248429-18248430`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_1ed45_24dab0.json?f_userOrOld=uploaded%20sample&label=id:node_10831638 image

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Branch 35, side-branch to JJ.1

Transferred to main repo _Transferred to cov-lineages/pango-designation#2354_ **Defining Mutations:** **EG.5.1.4** > `C26111T(ORF3:P240L)` > `C18555T` > `T17268C` > `G22927T(S:L455F)` **Query:** `T17268C, G22927T, C26111T` **Earliest seq:** 2023-08-08 (`EPI_ISL_18132133`, Newfoundland and Labrador) **Latest seq:** 2023-10-23 (`EPI_ISL_18448815`, Ontario, Canada) **Sampled Countries:** Canada (49: ON/22; NL/15; AB/10; BC/1; NS/1), US (7: CA/2; NY/2; AZ/1; UT/1; VA/1), France (1)
Genomes: `EPI_ISL_18132133, EPI_ISL_18256806, EPI_ISL_18258767, EPI_ISL_18258769-18258770, EPI_ISL_18258773, EPI_ISL_18258778, EPI_ISL_18291996, EPI_ISL_18291998, EPI_ISL_18292017, EPI_ISL_18292020-18292022, EPI_ISL_18292026-18292028, EPI_ISL_18333999, EPI_ISL_18344763, EPI_ISL_18357035, EPI_ISL_18372328, EPI_ISL_18372367, EPI_ISL_18383112, EPI_ISL_18383123-18383124, EPI_ISL_18383697, EPI_ISL_18388693, EPI_ISL_18395288, EPI_ISL_18395414, EPI_ISL_18395581, EPI_ISL_18404467, EPI_ISL_18425010, EPI_ISL_18425420, EPI_ISL_18425431, EPI_ISL_18425847, EPI_ISL_18425967, EPI_ISL_18426727, EPI_ISL_18427300, EPI_ISL_18427492, EPI_ISL_18427494, EPI_ISL_18427496, EPI_ISL_18427507, EPI_ISL_18427602, EPI_ISL_18431345, EPI_ISL_18436820, EPI_ISL_18437028, EPI_ISL_18437176, EPI_ISL_18438632, EPI_ISL_18438777, EPI_ISL_18448237, EPI_ISL_18448584-18448585, EPI_ISL_18448588, EPI_ISL_18448699-18448700, EPI_ISL_18448702, EPI_ISL_18448740, EPI_ISL_18448815`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_17f71_c79a0.json?f_userOrOld=uploaded%20sample&label=id:node_3447785 view from EG.5.1.4 polytomy ![sc](https://github.com/cov-lineages/pango-designation/assets/125747944/ebe6d072-41ab-4699-892f-106d43762671) details ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/eedd1bf9-8911-4fee-a970-ca8e9fca6d2f)

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Branch 36

Transferred to main repo: _Transferred to cov-lineages/pango-designation#2399_ **Defining Mutations:** **EG.5.1.1** > `C22388T(S:L276L)` > `G22927T(S:L455F)`, mostly with >> `C1853T` sub-branch **Query:** `C1853T, G13627A, G22927T, -C4780T, -C5031T, -C6627T, -C8982A` (for major `C1853T` sub-branch only) **Earliest seq:** 2023-08-14 (`EPI_ISL_18224087`, Colorado, USA) **Latest seq:** 2023-11-20 (`EPI_ISL_18568071`, `SEA` airport, travel history: France) **Sampled Countries:** France (20), Norway (12), Germany (11), Switzerland (8), USA (6: CO/2; ex. France/2; ex.Germany/2), UK (4: EN), China (3: XJ/2; FJ/1), Denmark (3), Ukraine (3), Canada (2: NB; ON), Finland (2), Spain (2), Belgium (1), Italy (1), Japan (1), Singapore (1)
Genomes: `EPI_ISL_18224087, EPI_ISL_18224096, EPI_ISL_18233134, EPI_ISL_18239749, EPI_ISL_18263561, EPI_ISL_18263571, EPI_ISL_18263574, EPI_ISL_18263576, EPI_ISL_18272601-18272602, EPI_ISL_18280654, EPI_ISL_18280813, EPI_ISL_18290994, EPI_ISL_18291008, EPI_ISL_18291011, EPI_ISL_18308259, EPI_ISL_18313749, EPI_ISL_18326424, EPI_ISL_18326608, EPI_ISL_18327645, EPI_ISL_18337648, EPI_ISL_18337651, EPI_ISL_18338378, EPI_ISL_18373487, EPI_ISL_18373856, EPI_ISL_18380089, EPI_ISL_18380091, EPI_ISL_18388662, EPI_ISL_18388711, EPI_ISL_18411952, EPI_ISL_18412072, EPI_ISL_18421745, EPI_ISL_18421949, EPI_ISL_18428144, EPI_ISL_18428460, EPI_ISL_18428992, EPI_ISL_18433011, EPI_ISL_18441991, EPI_ISL_18451507, EPI_ISL_18464584, EPI_ISL_18464947, EPI_ISL_18468968, EPI_ISL_18476770, EPI_ISL_18485554, EPI_ISL_18486361, EPI_ISL_18486756, EPI_ISL_18493947, EPI_ISL_18494748, EPI_ISL_18495920, EPI_ISL_18496297, EPI_ISL_18496628, EPI_ISL_18496636, EPI_ISL_18496703, EPI_ISL_18499460, EPI_ISL_18505686, EPI_ISL_18505750, EPI_ISL_18519177-18519178, EPI_ISL_18525816, EPI_ISL_18530654, EPI_ISL_18530657-18530658, EPI_ISL_18530757, EPI_ISL_18530938, EPI_ISL_18530967, EPI_ISL_18538000, EPI_ISL_18540615, EPI_ISL_18540768, EPI_ISL_18540871, EPI_ISL_18540915, EPI_ISL_18544152, EPI_ISL_18552615, EPI_ISL_18553571, EPI_ISL_18556840, EPI_ISL_18568060, EPI_ISL_18568071, EPI_ISL_18568733-18568735, EPI_ISL_18570228`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_bd36_c24960.json?label=id:node_3504156 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/7a99bd61-6514-4aa5-a049-96e0c5fe601a)

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Branch 37

C29095T became homoplastic across the EG.5.1+L455F tree, no longer tracking.

No longer tracking **Defining Mutations:** **EG.5.1.1** > `C29095T` > `G22927T(S:L455F)` **Query:** `G13627A, G22927T, C29095T` **Earliest seq:** 2023-08-28 (`EPI_ISL_18246374`, Sichuan, China) **Latest seq:** 2023-08-31 (`EPI_ISL_18264700`, Texas, USA) **Sampled Countries:** USA (2: TX), China (1: SC)
Genomes: `EPI_ISL_18246374, EPI_ISL_18264482, EPI_ISL_18264700`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_832a_59eef0.json?f_userOrOld=uploaded%20sample&label=id:node_10885350 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/31d6a883-5850-42ab-ad89-839167a19b8a)

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Branch 38

Defining Mutations: EG.5.1.1 > T24583C > G22927T(S:L455F) Query: C6541T, G22927T, T24583C Earliest seq: 2023-08-03 (EPI_ISL_18166149, Sichuan) Latest seq: 2023-08-26 (EPI_ISL_18268462 Shanghai) Sampled Countries: China (3: SC/2; SH/1)

Genomes: `EPI_ISL_18166149, EPI_ISL_18232692, EPI_ISL_18268462`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_f9a8_5a58c0.json?f_userOrOld=uploaded%20sample&label=id:node_10885352 image

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Branch 39

Defining Mutations: HK.1 (EG.5.1.1.1) > G22927T(S:L455F) Query: C6541T, G13627A, G22332T, G22927T + C6541T, G13627A, G22332A, G22927T Earliest seq: 2023-08-09 (EPI_ISL_18146086, Hubei) Latest seq: 2023-08-28 (EPI_ISL_18254226, Hubei) Sampled Countries: China (7)

Genomes: `EPI_ISL_18146086, EPI_ISL_18146100, EPI_ISL_18254226-18254227, EPI_ISL_18268425, EPI_ISL_18138066, EPI_ISL_18254258`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_1cca6_5afd40.json?f_userOrOld=uploaded%20sample&label=id:node_6971951 image

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Branch 40

Defining Mutations: EG.5.1.1 > C10615T > G22927T(S:L455F) > C1426T, G25691T(ORF3a:G100V) Query: C1426T, C10615T, G22927T Earliest seq: 2023-08-08 (EPI_ISL_18138249, Shanghai) Latest seq: 2023-08-25 (EPI_ISL_18268441, Shanghai) Sampled Countries: China (4: SH)

Genomes: `EPI_ISL_18138249, EPI_ISL_18208636, EPI_ISL_18268441, EPI_ISL_18268482`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_20010_5b23f0.json?f_userOrOld=uploaded%20sample&label=id:node_6983332 image

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Branch 41

Defining Mutations: EG.5.1.1 > C24023T > C2485T, G15025A(ORF1b:A520T), G22927C(S:L455F) Query: C6541T, G22927C, C24023T Earliest seq: 2023-08-14 (EPI_ISL_18239206, South Korea) Latest seq: 2023-08-24 (EPI_ISL_18254859, South Korea) Sampled Countries: South Korea (3)

Genomes: `EPI_ISL_18239206, EPI_ISL_18254859, EPI_ISL_18271926`

UShER: https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_26c10_8252f0.json?f_userOrOld=uploaded%20sample&label=id:node_10885690 image

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Branch 42

Transferred to main repo _Transferred to cov-lineages/pango-designation#2355_ **Defining Mutations:** **EG.5.1.1** > `C22687T` > `G22927T(S:L455F)` **Query:** `C6541T, C22687T, G22927T, -T2145C, -A16482C, -C21191T` **Earliest seq:** 2023-08-14 (`EPI_ISL_18279039`, Singapore, travel history: China) **Latest seq:** 2023-09-01 (`EPI_ISL_18278560`, Alberta, Canada) **Sampled Countries:** China (21: GS/4; HB/3; XJ/3; AH/2; SC/2; SX/2; FJ/1; HK/1; QH/1; SH/1; YN/1), Australia (12: NSW/5; SA/4; QLD/1; TA/1; VIC/1), South Korea (8), Canada (6: AB), USA (3: AZ/1; ex. Australia/2), Singapore (2: Local/1; ex. China/1), Japan (1)
Genomes: `EPI_ISL_18146046, EPI_ISL_18213336, EPI_ISL_18217223, EPI_ISL_18278558, EPI_ISL_18278560, EPI_ISL_18279039, EPI_ISL_18289881, EPI_ISL_18293677, EPI_ISL_18293698, EPI_ISL_18311984, EPI_ISL_18312274, EPI_ISL_18312380, EPI_ISL_18313209, EPI_ISL_18327623, EPI_ISL_18327666, EPI_ISL_18346251, EPI_ISL_18346325, EPI_ISL_18347707, EPI_ISL_18350428, EPI_ISL_18360224, EPI_ISL_18361336, EPI_ISL_18361999, EPI_ISL_18365676, EPI_ISL_18365684, EPI_ISL_18365890, EPI_ISL_18366374, EPI_ISL_18382081, EPI_ISL_18382589, EPI_ISL_18382710, EPI_ISL_18384562, EPI_ISL_18388967, EPI_ISL_18389014, EPI_ISL_18389016, EPI_ISL_18390872, EPI_ISL_18396110, EPI_ISL_18401894, EPI_ISL_18401903, EPI_ISL_18401983, EPI_ISL_18404054, EPI_ISL_18408752, EPI_ISL_18411422, EPI_ISL_18411665, EPI_ISL_18411717, EPI_ISL_18411753, EPI_ISL_18425089, EPI_ISL_18427884, EPI_ISL_18435235, EPI_ISL_18438336, EPI_ISL_18438338, EPI_ISL_18438347, EPI_ISL_18439100, EPI_ISL_18447517, EPI_ISL_18447771`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_27ac0_cb920.json?f_userOrOld=uploaded%20sample&label=id:node_3487678 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/f169acff-e2c6-411a-9a48-74e4c93d0080)

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Branch 43

now seems to be pulled under HK.3, no longer tracking

Pulled under HK.3 **Defining Mutations:** **EG.5.1.1** > `C19524T` > `G22927T(S:L455F), A28254Δ` **Query:** `G13627A, C19524T, G22927T, -C5031T` **Earliest seq:** 2023-08-19 (`EPI_ISL_18246322`, Sichuan) **Latest seq:** 2023-09-07 (`EPI_ISL_18277156`, Fujian) **Sampled Countries:** China (3: FJ; HL; SC)
Genomes: `EPI_ISL_18246049, EPI_ISL_18246322, EPI_ISL_18277156`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice2_genome_22869_97c570.json?f_userOrOld=uploaded%20sample&label=id:node_6973155 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/0d31d03f-4db8-40d2-83b4-2251d6576905)

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Branch 44, "FLippeR"

Transferred to main Repo _Transferred to cov-lineages/pango-designation#2296_ **Defining Mutations:** **EG.5.1** > `A22106C(S:K182Q)` > `C22995G(S:T478R), A25664G(ORF3a:Y91C)` > `C1613T(ORF1a:L450F), G20995T(ORF1b:G2510C), G22927C(S:L455F), C25803T, A27388C` **Query:** `A22106C, G22927C, C22995G` **Earliest seq:** 2023-08-14 (`EPI_ISL_18160020`, Denmark, or, `EPI_ISL_18278998`, Singapore) **Latest seq:** 2023-09-04 (`EPI_ISL_18243476`, Singapore) **Sampled Countries:** Singapore (2), Denmark (1)
Genomes: `EPI_ISL_18160020, EPI_ISL_18243476, EPI_ISL_18278998`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_13bc1_9943e0.json?f_userOrOld=uploaded%20sample&label=id:node_6964487 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/fcb5c1b8-c4ad-45ad-9de2-4ea85fb99d11)

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Branch 45

Transferred to main Repo _Transferred to cov-lineages/pango-designation#2308_ **Defining Mutations:** `EG.5.1.1` > `C13968A, A15885G` > `T11449C` > `C10369T, G22927T(S:L455F), C29077T, G29140T(N:Q289H)` **Query:** `T11449C, C13968A, G22927T` **Earliest seq:** 2023-09-06 (`EPI_ISL_18273676`, England) **Latest seq:** 2023-09-07 (`EPI_ISL_18284457`, `IAD` Airport, DC, travel history: Italy) **Sampled Countries:** UK (2: EN) USA (2, ex. Italy)
Genomes: `EPI_ISL_18273676, EPI_ISL_18281373, EPI_ISL_18284072, EPI_ISL_18284457`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_2d447_b0ad70.json?f_userOrOld=uploaded%20sample&label=id:node_6985113 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/27b21ec6-1008-464f-af1b-63360739cd44)

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Branch 46 with a sub-lineage of S:L452Q, designated as HK.22

parental lineage of HK.22 _Branch 46 + S:L452Q designated as HK.22 via cov-lineages/pango-designation@2d3115a_ **Defining Mutations:** `EG.5.1.1` > `G25407T(ORF3a:M5I)` > `C2662T` > `G22927T(S:L455F)` **Query:** `C2662T, G22927T, G25407T` **Earliest seq:** 2023-08-06 (`EPI_ISL_18114750`, Shanghai) **Latest seq:** 2023-09-06 (`EPI_ISL_18284970`, Shanghai) **Sampled Countries:** China (4: SH)
Genomes: `EPI_ISL_18114750, EPI_ISL_18232688, EPI_ISL_18284888, EPI_ISL_18284970`
**UShER:** https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_38b1_b0cc80.json?f_userOrOld=uploaded%20sample ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/7e73e4f7-3aad-4d6b-b19e-33927c86bc31)

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Branch 47

Defining Mutations: EG.5.1.1 > C7600T > G22927T(S:L455F) > T10216C Query: C7600T, T10216C, G22927T Earliest seq: 2023-08-22 (EPI_ISL_18246331, Sichuan) Latest seq: 2023-09-04 (EPI_ISL_18284731, Hubei) Sampled Countries: China (5)

Genomes: `EPI_ISL_18246331, EPI_ISL_18284731, EPI_ISL_18284776, EPI_ISL_18284783, EPI_ISL_18284960`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3ad47_b108e0.json?f_userOrOld=uploaded%20sample&label=id:node_10899080 image

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Branch 48

Transferred to main repo Transferred to cov-lineages/pango-designation#2360 ⚠️ Please check potential misplacement. **Defining Mutations:** `EG.5.1.1` > `A23539T(S:S659S)` > `G22927T(S:L455F)` **Query:** `G13627A, G22927T, A23539T, -T899C, -C2662T, -C10015T, -T12865C, -G22332A` **Earliest seq:** 2023-08-16 (`EPI_ISL_18141107`, Singapore) **Latest seq:** 2023-10-22 (`EPI_ISL_18440472`, Netherlands) **Sampled Countries:** Australia (32: NSW/14; SA/8; QLD/4; VIC/3; TAS/1; WA/1), China (10: SC/4; HB/2; SH/2; FJ/1; XJ/1), New Zealand (9), Singapore (4), Netherlands (3), USA (2), France (1)
Genomes: `EPI_ISL_18141107, EPI_ISL_18246326, EPI_ISL_18278997, EPI_ISL_18279955, EPI_ISL_18292475, EPI_ISL_18300669, EPI_ISL_18307132, EPI_ISL_18320781, EPI_ISL_18324527, EPI_ISL_18324537, EPI_ISL_18324951, EPI_ISL_18346779, EPI_ISL_18346805, EPI_ISL_18346818, EPI_ISL_18347516, EPI_ISL_18347639, EPI_ISL_18347703-18347704, EPI_ISL_18347710, EPI_ISL_18352381, EPI_ISL_18355046, EPI_ISL_18360352, EPI_ISL_18365605, EPI_ISL_18365672, EPI_ISL_18365874, EPI_ISL_18376439, EPI_ISL_18388898, EPI_ISL_18396188, EPI_ISL_18411419, EPI_ISL_18411467, EPI_ISL_18411551, EPI_ISL_18411564, EPI_ISL_18411674, EPI_ISL_18411695, EPI_ISL_18423924, EPI_ISL_18427871, EPI_ISL_18428112, EPI_ISL_18435043, EPI_ISL_18438373, EPI_ISL_18440466, EPI_ISL_18440472, EPI_ISL_18440476, EPI_ISL_18442757, EPI_ISL_18442774, EPI_ISL_18447732, EPI_ISL_18454463, EPI_ISL_18454489, EPI_ISL_18457508, EPI_ISL_18459380, EPI_ISL_18459604, EPI_ISL_18459721, EPI_ISL_18459855, EPI_ISL_18459912, EPI_ISL_18459940, EPI_ISL_18461585, EPI_ISL_18461782, EPI_ISL_18461792, EPI_ISL_18461895, EPI_ISL_18461916, EPI_ISL_18461956, EPI_ISL_18464115`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_2e62_757100.json?label=id:node_3495970 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/0c8ae009-2418-4dc0-91ad-5509025355a1) **Trivia:** - Please check potential misplacement: it seems only one seqs preceeding `S:L455F` branch, being `Sichuan/BZCDC-043/2023|EPI_ISL_17988879|2023-06-12`; however the mutations on the follow-up sub-branch `G571A, C2263A, A28959G` are "unique" to the EG.5.1.1* tree which may support it be a different lineage than `HK.3`.

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Branch 49

Now at least 3 smaller clusters seems pulled together a S:L455F branch right under EG.5.1.4 polytomy, hard to catch by proper query now.

Query failed **Defining Mutations:** `EG.5.1.4` > `C8407T, C11008A(ORF1a:H3581Q), G22927T(S:L455F), G25538T(ORF3a:G49V), C25572T` **Query:** `A18492G, A21137G, G22927T, -C6120T, -G13627A, -C26111T` **Earliest seq:** 2023-08-21 (`EPI_ISL_18284756`, Hubei) **Latest seq:** 2023-09-03 (`EPI_ISL_18284729`, Hubei) **Sampled Countries:** China (3)
Genomes: `EPI_ISL_18284721, EPI_ISL_18284729, EPI_ISL_18284756`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_176c9_b20830.json?f_userOrOld=uploaded%20sample&label=id:node_10899080 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/7d19e39f-fde3-4a4e-a586-d1ab877b9ca1)

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Branch 50

Defining Mutations: EG.5.1.1 > G28904T(N:A211S) > G22927T(S:L455F), G27261T, C28744T Query: C6541T, G22927T, G28904T Earliest seq: 2023-08-30 (EPI_ISL_18268410, Shanghai) Latest seq: 2023-09-03 (EPI_ISL_18254255, Hubei) Sampled Countries: China (5)

Genomes: `EPI_ISL_18254255, EPI_ISL_18268410, EPI_ISL_18289864, EPI_ISL_18289874, EPI_ISL_18289889`

UShER: https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_523af_c118f0.json?f_userOrOld=uploaded%20sample&label=id:node_6955662 image

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Branch 51

Transferred to main repo _transferred to cov-lineages/pango-designation#2365_ **Defining Mutations:** EG.5.1.1 > `C10015T` > `G22927T(S:L455F)` **Query:** `C6541T, C10015T, G22927T, -C4586T` **Earliest seq:** 2023-07-31 (`EPI_ISL_18246153`, Heilongjiang) **Latest seq:** 2023-10-31 (`EPI_ISL_18473950`, Spain) **Sampled Countries:** China (20: SH/6; HL/5; LN/3; AH/1; BJ/1; GS/1; HB/1; SC/1; SX/1; XJ/1), Canada (10: ON/9; NS/1), Australia (5: NSW/4; QLD/1), Singapore (5), Spain (5), Croatia (4), USA (3: NY/2; HI/1), Denmark (2), Japan (2), Belgium (1), France (1), Italy (1), Switzerland (1)
Genomes: `EPI_ISL_18246153, EPI_ISL_18268220, EPI_ISL_18284760, EPI_ISL_18289806, EPI_ISL_18304238, EPI_ISL_18307185, EPI_ISL_18309728, EPI_ISL_18320892, EPI_ISL_18333882, EPI_ISL_18354453, EPI_ISL_18356455, EPI_ISL_18362071, EPI_ISL_18382338, EPI_ISL_18384364, EPI_ISL_18388937, EPI_ISL_18388943, EPI_ISL_18392626, EPI_ISL_18392641, EPI_ISL_18395616, EPI_ISL_18398918, EPI_ISL_18401900, EPI_ISL_18422863, EPI_ISL_18425076, EPI_ISL_18433557, EPI_ISL_18438020, EPI_ISL_18438314, EPI_ISL_18438838, EPI_ISL_18445101, EPI_ISL_18445501, EPI_ISL_18446144, EPI_ISL_18448315, EPI_ISL_18448907-18448908, EPI_ISL_18448913-18448914, EPI_ISL_18461557, EPI_ISL_18461608, EPI_ISL_18461684, EPI_ISL_18461722, EPI_ISL_18464481, EPI_ISL_18464633, EPI_ISL_18465094, EPI_ISL_18465113, EPI_ISL_18465171, EPI_ISL_18465395, EPI_ISL_18465403, EPI_ISL_18466062, EPI_ISL_18466326-18466327, EPI_ISL_18466420, EPI_ISL_18466590, EPI_ISL_18470572, EPI_ISL_18471609, EPI_ISL_18471611, EPI_ISL_18473319, EPI_ISL_18473421, EPI_ISL_18473950, EPI_ISL_18475156, EPI_ISL_18475172, EPI_ISL_18475181, EPI_ISL_18475190, EPI_ISL_18475453`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_25e8a_b47430.json?label=id:node_3494261 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/8b3d4bc0-5d1a-439a-8ad5-e4f1bf14da67)

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Branch 52, now pulled under HK.3.2

Now part of HK.3.2 **Defining Mutations:** `EG.5.1.1` > `C26029A(ORF3a:Q213K)` > `G22927T(S:L455F)` **Query:** `C6541T, G22927T, C26029A, -G24944T, -A26901G` **Earliest seq:** 2023-08-16 (`EPI_ISL_18146001`, Hubei, China) **Latest seq:** 2023-09-20 (`EPI_ISL_18340137`, Illinois, USA) **Sampled Countries:** China (5: HB/3; SC; YN) USA (3: IL; NY; WA), Oman (1)
Genomes: `EPI_ISL_18146001, EPI_ISL_18246341, EPI_ISL_18290983, EPI_ISL_18292780, EPI_ISL_18313122, EPI_ISL_18322921, EPI_ISL_18330205, EPI_ISL_18333620, EPI_ISL_18340137`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_36145_d6af90.json?f_userOrOld=uploaded%20sample&label=id:node_3648445 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/4c9dae65-c4c4-4533-b700-c93e312c3267)

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Branch 53

Transferred to main repo _transferred to cov-lineages/pango-designation#2366_ **Defining Mutations:** `EG.5.1.1` > `C27741T` > `C1912T, C1968T(ORF1a:T568I), T7111C, A20010T(ORF1b:Q2181H), T20592C, G22927C(S:L455F), C28093T(ORF8:S67F)` **Query:** `C6541T, G22927C, C27741T` **Earliest seq:** 2023-08-28 (`EPI_ISL_18345224`, Cork, Ireland) **Latest seq:** 2023-10-23 (`EPI_ISL_18471085`, Connecticut, USA) **Sampled Countries:** UK (17: EN/16; WS/1), USA (14: NY/3; NJ/2; TX/2; UT/2; AZ/1; CA/1; CT/1; MN/1; OH/1), Ireland (9), Canada (4: ON/3; BC/1), Denmark (2), France (2), China (2: SC/1; ex. Spain/1), Belgium (1), South Korea (1), Netherlands (1)
Genomes: `EPI_ISL_18250090, EPI_ISL_18284832, EPI_ISL_18290882, EPI_ISL_18290915, EPI_ISL_18308328, EPI_ISL_18308339, EPI_ISL_18315360, EPI_ISL_18321565, EPI_ISL_18332107, EPI_ISL_18332505, EPI_ISL_18345224, EPI_ISL_18354139, EPI_ISL_18362839, EPI_ISL_18362880-18362881, EPI_ISL_18362951, EPI_ISL_18375850, EPI_ISL_18377642, EPI_ISL_18385706, EPI_ISL_18385720, EPI_ISL_18385728, EPI_ISL_18385734, EPI_ISL_18388184, EPI_ISL_18388760-18388761, EPI_ISL_18389241, EPI_ISL_18398829, EPI_ISL_18399988, EPI_ISL_18400877, EPI_ISL_18403587, EPI_ISL_18403998, EPI_ISL_18407932, EPI_ISL_18416430, EPI_ISL_18416450, EPI_ISL_18420893, EPI_ISL_18420911, EPI_ISL_18422267, EPI_ISL_18427521, EPI_ISL_18429173, EPI_ISL_18429518, EPI_ISL_18430506, EPI_ISL_18433870, EPI_ISL_18438642, EPI_ISL_18442008, EPI_ISL_18443922, EPI_ISL_18448322, EPI_ISL_18452961, EPI_ISL_18456955, EPI_ISL_18467439, EPI_ISL_18467445, EPI_ISL_18467479, EPI_ISL_18471085, EPI_ISL_18475314`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_2eee6_b4b600.json?label=id:node_3484946 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/7a31b77c-042f-44ee-b8fc-0e102b4632b7)

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Branch 54:

Defining Mutations: EG.5.1.1 > G24368T(S:D936Y) > G22927T(S:L455F) Query: G13627A, G22927T, G24368T, -G3567A, -C4012T, -C5031T, -T13234C, -C17976T Earliest seq: 2023-09-11 (EPI_ISL_18312655, South Korea) Latest seq: 2023-11-24 (EPI_ISL_18567787, Veneto, Italy) Sampled Countries: Finland (15), South Korea (15), USA (9: NY/7; UT/2), Italy (2), Singapore (2), Australia (1: QLD), Germany (1)

Genomes: `EPI_ISL_18312655, EPI_ISL_18343453, EPI_ISL_18347772, EPI_ISL_18347778, EPI_ISL_18347783, EPI_ISL_18347794, EPI_ISL_18347862, EPI_ISL_18354114, EPI_ISL_18394470, EPI_ISL_18408694, EPI_ISL_18411981, EPI_ISL_18411986, EPI_ISL_18412002, EPI_ISL_18412024, EPI_ISL_18412052, EPI_ISL_18412131, EPI_ISL_18439287, EPI_ISL_18439475, EPI_ISL_18445086, EPI_ISL_18445161, EPI_ISL_18449963, EPI_ISL_18458264, EPI_ISL_18458329, EPI_ISL_18460569, EPI_ISL_18502041, EPI_ISL_18503589, EPI_ISL_18511443, EPI_ISL_18533418, EPI_ISL_18533465, EPI_ISL_18533560, EPI_ISL_18533727, EPI_ISL_18534149, EPI_ISL_18539237, EPI_ISL_18539435, EPI_ISL_18539679, EPI_ISL_18539701, EPI_ISL_18539776, EPI_ISL_18541395, EPI_ISL_18541532, EPI_ISL_18544389, EPI_ISL_18547900, EPI_ISL_18554927, EPI_ISL_18555070, EPI_ISL_18564736, EPI_ISL_18567787`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_28b3b_c482d0.json?label=id:node_3526683 image

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Branch 55

Designated with 2 levesl: HK.24 and HK.24.1 Designated as [HK.24](https://github.com/cov-lineages/pango-designation/commit/211018361b201eda9d492fdb25dc7fbcad217804) and [HK.24.1](https://github.com/cov-lineages/pango-designation/commit/77596389b8d6291450be40a5b8a7c1701c9e5309) **Defining Mutations:** `EG.5.1.1` > `G23522A(S:E654K)` > `G22927T(S:L455F)` **Query:** `C6541T, G22927T, G23522A` **Earliest seq:** 2023-08-26 (`EPI_ISL_18284795`, Shanghai, China) **Latest seq:** 2023-09-24 (`EPI_ISL_18346833`, South Australia, Australia) **Sampled Countries:** Australia (6: QLD/2; WA/2; NSW; SA), China (3: SH), New Zealand (1)
Genomes: `EPI_ISL_18284795, EPI_ISL_18284982, EPI_ISL_18324864, EPI_ISL_18346833, EPI_ISL_18347678, EPI_ISL_18352382, EPI_ISL_18352389, EPI_ISL_18352581, EPI_ISL_18354460, EPI_ISL_18360253`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_222ea_2ee540.json?f_userOrOld=uploaded%20sample&label=id:node_3445909 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/c10096c2-de1d-4afe-b950-45cb5ba050e2)

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Branch 56

Defining Mutations: EG.5.1.1 > A22582G(S:E340) > G22927T(S:L455F) Query: G13627A, A22582G, G22927T, -G3153A Earliest seq: 2023-08-30 (EPI_ISL_18303241, Portugal) Latest seq: 2023-09-25 (EPI_ISL_18355054, Singapore) Sampled Countries: Portugal (2), Singapore (2), China (1: QH), UK (1: EN)

Genomes: `EPI_ISL_18268272, EPI_ISL_18274005, EPI_ISL_18303241, EPI_ISL_18303432, EPI_ISL_18307200, EPI_ISL_18355054`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_61cc_2ffcf0.json?label=id:node_3450332 image

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Branch 57

Defining Mutations: EG.5.1.1 > A22582G(S:E340) > G3153A(ORF1a:G963D) > G22927T(S:L455F) Query: G3153A, A22582G, G22927T Earliest seq: 2023-08-14 (EPI_ISL_18146012, Hubei, China) Latest seq: 2023-09-26 (EPI_ISL_18350530, Basque, Spain) Sampled Countries: China (4: FJ; HB; HK; SH), Japan (2), South Korea (2), USA (2: ex. Greece), Spain (1)

Genomes: `EPI_ISL_18146012, EPI_ISL_18277143, EPI_ISL_18293356, EPI_ISL_18306220, EPI_ISL_18306632, EPI_ISL_18306769, EPI_ISL_18309318, EPI_ISL_18309324, EPI_ISL_18350530, EPI_ISL_18354289, EPI_ISL_18360277`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_61cc_2ffcf0.json?label=id:node_3450116 image

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Branch 58, formerly singlet, thanks to @aviczhl2 for updated info

Defining Mutations: EG.5.1 > T26972C > C28909T > C2106A(ORF1a:T614N), G28423T(ORF9b:R47L) > A21759G(S:H66R), G22927T(S:L455F), G24004A(S:K814), C25572T Query: A18492G, G22927T, C28909T Earliest seq: 2023-08-21 (EPI_ISL_18271704, S. Korea) Latest seq: 2023-09-19 (EPI_ISL_18355498, S. Korea) Sampled Countries: South Korea (6)

Genomes: `EPI_ISL_18271704, EPI_ISL_18354058, EPI_ISL_18354072, EPI_ISL_18354264, EPI_ISL_18355236, EPI_ISL_18355498`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_26418_30eca0.json?label=id:node_3429102 image

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Branch 59: ⚠️ careful with potential dropout/misplacement.

Defining Mutations: EG.5.1.1 > G20134T(ORF1b:V2223L) > G22927T(S:L455F) Query: G13627A, G20134T, G22927T Earliest seq: 2023-09-04 (EPI_ISL_18300595, New South Wales) Latest seq: 2023-10-03 (EPI_ISL_18361370, NSW) Sampled Countries: Australia (17: NSW/16; QLD)

Genomes: `EPI_ISL_18300595, EPI_ISL_18300598, EPI_ISL_18300624, EPI_ISL_18300634, EPI_ISL_18300676-18300679, EPI_ISL_18300732, EPI_ISL_18300745-18300746, EPI_ISL_18300790, EPI_ISL_18324806, EPI_ISL_18352578, EPI_ISL_18361360-18361361, EPI_ISL_18361370`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_4fa9_6ad320.json?label=id:node_3451611 image

Trivia:

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Branch 60: Formerly Y144F artifact branch now masked

Defining Mutations: EG.5.1.1 > T16545G > C1471T, G22927T(S:L455F) Query: G13627A, T16545G, G22927T Earliest seq: 2023-08-25 (EPI_ISL_18228384, Finland) Latest seq: 2023-10-04 (EPI_ISL_18362018, Singapore) Sampled Countries: Singapore (7), China (3: SH/2; HB), Finland (1)

Genomes: `EPI_ISL_18228384, EPI_ISL_18243407, EPI_ISL_18254180, EPI_ISL_18306951, EPI_ISL_18320869, EPI_ISL_18360325, EPI_ISL_18361717, EPI_ISL_18361964, EPI_ISL_18362005, EPI_ISL_18362018, EPI_ISL_18362077`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_108b5_6b1720.json?f_userOrOld=uploaded%20sample&label=id:node_3457632 image

Trivia:

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Branch 61

⚠️ Please check potential reversion/artifact/misplacement, C26681T is quite homoplastic in HK.3*, no longer tracking

potential HK.3 dropout **Defining Mutations:** `EG.5.1.1` > `C26681T` > `T5327C, C5986T, T22032C(S:F157S), G22927T(S:L455F)` **Query:** `T22032C, G22927T, C26681T` **Earliest seq:** 2023-09-03 (`EPI_ISL_18376557`, Sichuan) **Latest seq:** 2023-09-11 (`EPI_ISL_18376558`, Sichuan, _OR_ `EPI_ISL_18277141`, Fujian) **Sampled Countries:** China (5: SC/4; FJ)
Genomes: `EPI_ISL_18277141, EPI_ISL_18376556-18376559`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice14_genome_f688_7a5e50.json?label=id:node_3447615 ![image](https://github.com/sars-cov-2-variants/lineage-proposals/assets/125747944/54293b2a-569f-46a5-9652-15875f493154)

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Branch 62: With a sub-branch of FLippeR

Defining Mutations: EG.5.1.1 > C18559T(ORF1b:L1698F) > T15927C, G22927T(S:L455F) Query: C6541T, C18559T, G22927T Earliest seq: 2023-08-31 (EPI_ISL_18285056, Sichuan, China) Latest seq: 2023-09-20 (EPI_ISL_18382134, South Korea) Sampled Countries: China (4: SC/2; SH/2), South Korea (1)

Genomes: `EPI_ISL_18285056-18285057, EPI_ISL_18320863, EPI_ISL_18360320, EPI_ISL_18382134`

UShER: https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_24de1_9159b0.json?label=id:node_3445922 image

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Branch 63

⚠️ Please check potential misplacement

Transferred to main repo _Transferred to cov-lineages/pango-designation#2400_ **Defining Mutations:** `EG.5.1.1` > `T14034C` > `T6556C` > `G22927T(S:L455F)` **Query:** `T6556C, T14034C, G22927T` **Earliest seq:** 2023-08-28 (`EPI_ISL_18236022`, Chiba, Japan) **Latest seq:** 2023-11-16 (`EPI_ISL_18568493`, Ardèche, France) **Sampled Countries:** South Korea (66), Japan (11), France (7), China (2: Taiwan), Singapore (2), Germany (1), Ireland (1), UK (1: England)
Genomes: `EPI_ISL_18236022, EPI_ISL_18307101, EPI_ISL_18307183, EPI_ISL_18312967, EPI_ISL_18354179, EPI_ISL_18354386, EPI_ISL_18371409, EPI_ISL_18371437, EPI_ISL_18376385, EPI_ISL_18381917, EPI_ISL_18382077, EPI_ISL_18382170, EPI_ISL_18382306, EPI_ISL_18382313, EPI_ISL_18384744, EPI_ISL_18390972, EPI_ISL_18408733, EPI_ISL_18408999, EPI_ISL_18409046, EPI_ISL_18409110, EPI_ISL_18418096, EPI_ISL_18418099, EPI_ISL_18420466, EPI_ISL_18423347, EPI_ISL_18438958, EPI_ISL_18439063, EPI_ISL_18439157, EPI_ISL_18439221, EPI_ISL_18439371, EPI_ISL_18460530, EPI_ISL_18460541, EPI_ISL_18460589, EPI_ISL_18460966, EPI_ISL_18460978, EPI_ISL_18461033, EPI_ISL_18461094, EPI_ISL_18461485, EPI_ISL_18465933, EPI_ISL_18468665, EPI_ISL_18486472, EPI_ISL_18491815, EPI_ISL_18496187, EPI_ISL_18501996, EPI_ISL_18502046, EPI_ISL_18502053, EPI_ISL_18502059, EPI_ISL_18503696, EPI_ISL_18503846, EPI_ISL_18510036, EPI_ISL_18510038, EPI_ISL_18511034, EPI_ISL_18511095, EPI_ISL_18511104, EPI_ISL_18511108, EPI_ISL_18511172, EPI_ISL_18511241, EPI_ISL_18511380, EPI_ISL_18511416, EPI_ISL_18511461, EPI_ISL_18511469, EPI_ISL_18511480, EPI_ISL_18511508, EPI_ISL_18511521, EPI_ISL_18511532, EPI_ISL_18511557, EPI_ISL_18511580, EPI_ISL_18511661, EPI_ISL_18511670, EPI_ISL_18535606, EPI_ISL_18535663, EPI_ISL_18535697, EPI_ISL_18539307, EPI_ISL_18539369, EPI_ISL_18539422, EPI_ISL_18539428, EPI_ISL_18539447, EPI_ISL_18539483, EPI_ISL_18539547, EPI_ISL_18545014, EPI_ISL_18564392, EPI_ISL_18564436, EPI_ISL_18564462-18564463, EPI_ISL_18564564, EPI_ISL_18564669, EPI_ISL_18564752, EPI_ISL_18564926, EPI_ISL_18565014, EPI_ISL_18565195, EPI_ISL_18568493, EPI_ISL_18570360`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_21541_c2c6a0.json?label=id:node_3526922 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/5b90b3a7-63c8-46ce-9548-ea7813bc5bf0) **Trivia:** - Only 3 seqs preceeding this branch without `S:L455F`: `France/GES-IPP16513/2023|EPI_ISL_18109814|2023-07-241, `Australia/QLD0x0138F8/2023|EPI_ISL_18324553|2023-09-12`, and `SouthKorea/KDCA_270758/2023|EPI_ISL_18503707|2023-10-12` ⚠️ so please check potential dropout/misplacement.

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Branch 64

Defining Mutations: EG.5.1.6 > C28236T(ORF8:R115C) > C16092T > C10969T > G526T(ORF1a:E87D) > C23380T(S:N606) > A12485G(ORF1a:I4074V) > T877C, A15270T(ORF1b:E601D), G22927T(S:L455F) Query: G526T, A15270T, G22927T Earliest seq: 2023-10-08 (EPI_ISL_18404805, New Brunswick, Canada) Latest seq: 2023-10-15 (EPI_ISL_18427247, Ontario, Canada) Sampled Countries: Canada (4: ON/3; NB)

Genomes: `EPI_ISL_18404805, EPI_ISL_18426514, EPI_ISL_18426586, EPI_ISL_18427247`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_21e1_9e19a0.json?label=id:node_3437762 image

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Branch 65

Defining Mutations: EG.5.1 > A3210G(ORF1a:D982G) > G26888A > G26227T(_TRS of Envelope_), C28720T(_TRS of ORF9c_) > T8909C> G22927T(S:L455F) Query: A3210G, T8909C, G22927T Earliest seq: 2023-09-07 (EPI_ISL_18419405, Sicily, Italy) Latest seq: 2023-09-18 (EPI_ISL_18329969, Denmark) Sampled Countries: Italy (13), Denmark (1)

Genomes: `EPI_ISL_18258788-18258789, EPI_ISL_18329969, EPI_ISL_18419405, EPI_ISL_18419417, EPI_ISL_18419442, EPI_ISL_18419446, EPI_ISL_18419449, EPI_ISL_18419451, EPI_ISL_18419459, EPI_ISL_18419472, EPI_ISL_18419474, EPI_ISL_18419478, EPI_ISL_18419484`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3b9a_9e23b0.json?label=id:node_3428133 image

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Branch 66

Defining Mutations: EG.5.1.1 > C11779T > C12525T(ORF1a:T4087I) > G22927T(S:L455F) Query: C11779T, C12525T, G22927T Earliest seq: 2023-08-27 (EPI_ISL_18360191, England) Latest seq: 2023-10-09 (EPI_ISL_18421921, Belgium) Sampled Countries: South Korea (4), Canada (3: BC), Belgium (1), China (1: SH), New Zealand (1), Singapore (1), UK (1: EN)

Genomes: `EPI_ISL_18227053, EPI_ISL_18292157, EPI_ISL_18355538, EPI_ISL_18360191, EPI_ISL_18381927, EPI_ISL_18382266, EPI_ISL_18397328, EPI_ISL_18408737, EPI_ISL_18421921, EPI_ISL_18430928, EPI_ISL_18431490, EPI_ISL_18431860`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_34aaf_9ea630.json?label=id:node_3493682 image

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Branch 67

Defining Mutations: EG.5.1.1 > C25613T(ORF3a:S74F) > G22927C(S:L455F) Query: C6541T, G22927C, C25613T, -C26681T, -G26840A Earliest seq: 2023-10-12 (EPI_ISL_18428810, Singapore) Latest seq: 2023-10-16 (EPI_ISL_18428772, Singapore) Sampled Countries: Singapore (5)

Genomes: `EPI_ISL_18428766, EPI_ISL_18428769, EPI_ISL_18428771-18428772, EPI_ISL_18428810`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_41fd2_a0fe0.json?label=id:node_3487648 image

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Branch 68

Defining Mutations: EG.5.1.1 > G16710A > G22927T(S:L455F) Query: G16710A, G13627A, G22927T, -G28904T Earliest seq: 2023-09-25 (EPI_ISL_18355035, Singapore) Latest seq: 2023-10-18 (EPI_ISL_18428623, Singapore) Sampled Countries: Singapore (11)

Genomes: `EPI_ISL_18355035, EPI_ISL_18361806, EPI_ISL_18361914, EPI_ISL_18361935, EPI_ISL_18362103, EPI_ISL_18397258, EPI_ISL_18397453, EPI_ISL_18428554, EPI_ISL_18428623, EPI_ISL_18428638, EPI_ISL_18428659`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_c933_9f2590.json?label=id:node_3474466 image

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Branch 69

Defining Mutations: EG.5.1.1 > G1085T(ORF1a:V274L) > G1535A(ORF1a:V424I), G22927T(S:L455F) Query: G1085T, G13627A, G22927T, -A11000G, -C29375T, Earliest seq: 2023-10-02 (EPI_ISL_18361916, Singapore) Latest seq: 2023-10-16 (EPI_ISL_18428661, Singapore) Sampled Countries: Singapore (5)

Genomes: `EPI_ISL_18361916, EPI_ISL_18397376, EPI_ISL_18397599, EPI_ISL_18428562, EPI_ISL_18428661`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_18f8d_9f5e00.json?label=id:node_3486178 image

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Branch 70

Defining Mutations: EG.5.1.1 > T21748C(S:V62) > A16225G(ORF1b:T920A), T25036C > G22927C(S:L455F) Query: A16225G, T21748C, G22927C Earliest seq: 2023-08-10 (EPI_ISL_18438105, Beijing, China) Latest seq: 2023-10-09 (EPI_ISL_18426675, Montana, USA) Sampled Countries: China (13: BJ/11; HB/1; HL/1), Netherlands (2), Singapore (1), USA (1: MT)

Genomes: `EPI_ISL_18254239, EPI_ISL_18331365, EPI_ISL_18362093, EPI_ISL_18384410, EPI_ISL_18386767, EPI_ISL_18426675, EPI_ISL_18438074-18438075, EPI_ISL_18438082, EPI_ISL_18438103, EPI_ISL_18438105, EPI_ISL_18438108, EPI_ISL_18438114, EPI_ISL_18438136, EPI_ISL_18438177-18438178, EPI_ISL_18438235`

UShER: https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_4eb1c_b77620.json?label=id:node_3464035 image

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Branch 71

Defining Mutations: EG.5.1.1 > C6638T(ORF1a:H2125Y) > G22927T(S:L455F) Query: C6638T, G13627A, G22927T, -C14889T Earliest seq: 2023-09-11 (EPI_ISL_18313157, Hubei, China) Latest seq: 2023-10-09 (EPI_ISL_18438431, Hubei, China) Sampled Countries: China (5: HB), South Korea (1)

Genomes: `EPI_ISL_18313157-18313158, EPI_ISL_18382135, EPI_ISL_18438389, EPI_ISL_18438415, EPI_ISL_18438431`

UShER: https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_b5b8_b7aee0.json?f_userOrOld=uploaded%20sample&label=id:node_3482675 image

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Branch 72

Defining Mutations: EG.5.1.1 > C11779T > G10261A > C9611T(ORF1a:L3116F), C18348T > G22927T(S:L455F) Query: C9611T, C11779T, G22927T Earliest seq: 2023-09-06 (EPI_ISL_18313115, Hubei, China) Latest seq: 2023-10-09 (EPI_ISL_18406324, Vienna, Austria) Sampled Countries: South Korea (6), Singapore (2), Austria (1), China (1: HB)

Genomes: `EPI_ISL_18313115, EPI_ISL_18355007, EPI_ISL_18355538, EPI_ISL_18376812, EPI_ISL_18381927, EPI_ISL_18382266, EPI_ISL_18406324, EPI_ISL_18408737, EPI_ISL_18435658, EPI_ISL_18439298`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3b3db_cbcfb0.json?label=id:node_3497922 image

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Branch 73

Defining Mutations: EG.5.1.1 > C19170T > G22927T(S:L455F) Query: G13627A, C19170T, G22927T, -C1909T, -C3736T, -C5031T, -C7504T, -A18153G Earliest seq: 2023-08-31 (EPI_ISL_18438072, Beijing) Latest seq: 2023-10-14 (EPI_ISL_18442753, Sichuan) Sampled Countries: China (6: SC/3; BJ/1; HB/1; SC/1), South Korea (1)

Genomes: `EPI_ISL_18320875, EPI_ISL_18360251, EPI_ISL_18360272, EPI_ISL_18438072, EPI_ISL_18438352, EPI_ISL_18439041, EPI_ISL_18442753`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_26c5d_cced10.json?label=id:node_3466266 image

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Branch 74

Defining Mutations: EG.5.1.3 > A28032G(ORF8:I47V) > A1047C(ORF1a:K261T) > C3608A(ORF1a:L1115I), C18261T, G22927T(S:L455F) Query: A1047C, C1889T, G22927T Earliest seq: 2023-09-11 (EPI_ISL_18314192, France) Latest seq: 2023-10-12 (EPI_ISL_18441710, Netherlands) Sampled Countries: Belgium (2), France (2), Netherlands (1)

Genomes: `EPI_ISL_18314192, EPI_ISL_18337916, EPI_ISL_18338399, EPI_ISL_18399343, EPI_ISL_18441710`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_38cb6_cd6010.json?f_userOrOld=uploaded%20sample&label=id:node_3458506 image

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Branch 75

Defining Mutations: EG.5.1.1 > C29253T(N:S327L) > G22927T(S:L455F) Query: G13627A, G22927T, C29253T, -G1067T, -C2110T, -A2730C Earliest seq: 2023-08-17 (EPI_ISL_18389043, Xinjiang, China) Latest seq: 2023-10-24 (EPI_ISL_18445150, Singapore, travel history: Malaysia) Sampled Countries: Denmark (3), China (2: XJ), Singapore (2)

Genomes: `EPI_ISL_18320957, EPI_ISL_18377581, EPI_ISL_18377610, EPI_ISL_18389043, EPI_ISL_18397195, EPI_ISL_18442952, EPI_ISL_18445150`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_1c2e8_a8650.json?label=id:node_3492354 image

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Branch 76

Defining Mutations: EG.5.1.1 > T26609C > C5907T(ORF1a:T1881I), T17454A > G22927T(S:L455F) Query: G13627A, T17454A, G22927T Earliest seq: 2023-09-20 (EPI_ISL_18445852, Castilla y León, Spain) Latest seq: 2023-10-13 (EPI_ISL_18402965, Donostia-San Sebastián, Spain) Sampled Countries: Spain (9)

Genomes: `EPI_ISL_18402961, EPI_ISL_18402965, EPI_ISL_18419672, EPI_ISL_18421286, EPI_ISL_18445852, EPI_ISL_18445906, EPI_ISL_18445934, EPI_ISL_18446071-18446072`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3b023_af570.json?label=id:node_3474073 image

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Branch 77

Transferred to main repo _Transferred to cov-lineages/pango-designation#2401_ **Defining Mutations:** `EG.5.1.6` > `C925T, C27161T` > `C14919A` > `G14559A` > `G22927T(S:L455F)` **Query:** `C5835T, G14559A, G22927T` **Earliest seq:** 2023-09-11 (`EPI_ISL_18381025`, British Columbia, Canada) **Latest seq:** 2023-11-21 (`EPI_ISL_18572342`, Israel) **Sampled Countries:** Canada (59: AB/25; BC/25; SK/7; ON/1; QC/1), Israel (5), USA (3: NY/2; CA), Finland (2), Sweden (2), Austria (1), Ireland (1), UK (1: EN)
Genomes: `EPI_ISL_18313726, EPI_ISL_18374552, EPI_ISL_18381025, EPI_ISL_18381642, EPI_ISL_18399548, EPI_ISL_18405416, EPI_ISL_18429724, EPI_ISL_18431316, EPI_ISL_18431484, EPI_ISL_18431577, EPI_ISL_18448820, EPI_ISL_18449315, EPI_ISL_18451058, EPI_ISL_18452675, EPI_ISL_18453011, EPI_ISL_18453157, EPI_ISL_18456002, EPI_ISL_18456201, EPI_ISL_18493062, EPI_ISL_18499142, EPI_ISL_18501414, EPI_ISL_18501469, EPI_ISL_18501539, EPI_ISL_18501675, EPI_ISL_18512520, EPI_ISL_18512575, EPI_ISL_18512726, EPI_ISL_18512904, EPI_ISL_18512975, EPI_ISL_18513012, EPI_ISL_18516832, EPI_ISL_18516837, EPI_ISL_18517029, EPI_ISL_18517372, EPI_ISL_18517374-18517375, EPI_ISL_18517477, EPI_ISL_18517505, EPI_ISL_18526773, EPI_ISL_18526937-18526938, EPI_ISL_18526942, EPI_ISL_18526999, EPI_ISL_18527195, EPI_ISL_18532450-18532451, EPI_ISL_18533407, EPI_ISL_18538515, EPI_ISL_18538528, EPI_ISL_18538535, EPI_ISL_18538740, EPI_ISL_18538774, EPI_ISL_18538986, EPI_ISL_18541507-18541508, EPI_ISL_18547665, EPI_ISL_18552699, EPI_ISL_18553923, EPI_ISL_18553948, EPI_ISL_18558921, EPI_ISL_18560813, EPI_ISL_18563933, EPI_ISL_18563975, EPI_ISL_18563992, EPI_ISL_18564064, EPI_ISL_18564086, EPI_ISL_18564088, EPI_ISL_18564119, EPI_ISL_18564154, EPI_ISL_18564182, EPI_ISL_18564194, EPI_ISL_18572342, EPI_ISL_18572380, EPI_ISL_18572384`
**UShER:** https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_2d8f9_c314c0.json?label=id:node_3469419 ![image](https://github.com/cov-lineages/pango-designation/assets/125747944/c6c9b3f6-d7ed-46ce-a522-6c7068b9e27b)

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Branch 78

Defining Mutations: EG.5.1.1 > C18395T(ORF1b:A1643V) > G22927T(S:L455F) Query: C6541T, C18395T, G22927T Earliest seq: 2023-08-16 (EPI_ISL_18146006, Hubei, China) Latest seq: 2023-10-15 (EPI_ISL_18453170, British Columbia, Canada) Sampled Countries: Canada (7: BC), China (6: FJ/3; HB/2; GS/1), Japan (2)

Genomes: `EPI_ISL_18146006, EPI_ISL_18330196, EPI_ISL_18330296, EPI_ISL_18330311, EPI_ISL_18376315, EPI_ISL_18405472, EPI_ISL_18409239, EPI_ISL_18425055, EPI_ISL_18452695, EPI_ISL_18452923, EPI_ISL_18452979, EPI_ISL_18453059, EPI_ISL_18453168, EPI_ISL_18453170, EPI_ISL_18454186`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3e744_1f9880.json?label=id:node_3476703 image

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Branch 79

Defining Mutations: EG.5.1.1 > T6736C > T23287C(S:A575) > C22075T(S:V171) > C8389T, A16668G, C17474T(ORF1b:T1336I), G22927T(S:L455F), G26416T(E:V58F) Query: T6736C, G13627A, G22927T Earliest seq: 2023-08-17 (EPI_ISL_18241549, Yunnan) Latest seq: 2023-10-14 (EPI_ISL_18454380, Yunnan) Sampled Countries: China (12: YN)

Genomes: `EPI_ISL_18241549, EPI_ISL_18384462, EPI_ISL_18384468, EPI_ISL_18384485, EPI_ISL_18384488, EPI_ISL_18384501, EPI_ISL_18384510, EPI_ISL_18384514, EPI_ISL_18384522, EPI_ISL_18454363, EPI_ISL_18454380, EPI_ISL_18454383`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_6626_1fc330.json?label=id:node_3476751 image

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Branch 80

Defining Mutations: EG.5.1.1 > C8146T > G2035A, G6373T(ORF1a:M2036I), G22927T(S:L455F) Query: C8146T, G13627A, G22927T, -C27557T Earliest seq: 2023-08-28 (EPI_ISL_18289791, Anhui, China) Latest seq: 2023-10-07 (EPI_ISL_18454332, Yunnan, China) Sampled Countries: South Korea (6), China (3: AH, HB, YN)

Genomes: `EPI_ISL_18289791, EPI_ISL_18376503, EPI_ISL_18382123, EPI_ISL_18454332, EPI_ISL_18460781, EPI_ISL_18460783, EPI_ISL_18460821-18460822, EPI_ISL_18460834`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_1d9d0_762270.json?label=id:node_3494057 image

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Branch 81

Defining Mutations: EG.5.1.1 > C2857T > G22927T(S:L455F) Query: C2857T, G13627A, G22927T, -C5031T, -T17475C Earliest seq: 2023-09-14 (EPI_ISL_18388886, Hubei, China) Latest seq: 2023-10-13 (EPI_ISL_18461038, South Korea) Sampled Countries: China (7: TW/5; HB; SC), Belgium (1), Japan (1), South Korea (1)

Genomes: `EPI_ISL_18388886, EPI_ISL_18399792, EPI_ISL_18427833, EPI_ISL_18432501, EPI_ISL_18438519, EPI_ISL_18440359, EPI_ISL_18440668, EPI_ISL_18461038, EPI_ISL_18461507, EPI_ISL_18461514`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_5f66_766bb0.json?label=id:node_3485431 image

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Branch 82

Defining Mutations: EG.5.1.1 > T16494C, T22307C > G22927C(S:L455F) Query: G13627A, T16494C, G22927C Earliest seq: 2023-09-12 (EPI_ISL_18376962, Singapore, Travel History: Malaysia) Latest seq: 2023-10-09 (EPI_ISL_18461687, New South Wales, Australia) Sampled Countries: Singapore (7), China (2: HL), Australia (1: NSW)

Genomes: `EPI_ISL_18355070, EPI_ISL_18355078, EPI_ISL_18355084, EPI_ISL_18355119, EPI_ISL_18376962, EPI_ISL_18397262, EPI_ISL_18397335, EPI_ISL_18461687, EPI_ISL_18465032, EPI_ISL_18465036`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice14_genome_1351a_73edc0.json?label=id:node_3508527 image

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Branch 83

Defining Mutations: EG.5.1.1 > C29358T(N:T362I) > T23803C(S:T747T) > C842T(ORF1a:P193S), C15141T, T16743C, C22450T(S:L296L), G22927T(S:L455F), C24442T(S:N960N), C25916T(ORF3a:T175I), C28232T Query: G22927T, T23803C, C29358T Earliest seq: 2023-09-11 (EPI_ISL_18384535, Yunnan, China) Latest seq: 2023-10-31 (EPI_ISL_18473684, Singapore) Sampled Countries: Singapore (11), France (2), Australia (1: NSW), Canada (1: ON), China (1: YN), Germany (1)

Genomes: `EPI_ISL_18327437, EPI_ISL_18384535, EPI_ISL_18423274, EPI_ISL_18428663, EPI_ISL_18455125, EPI_ISL_18461961, EPI_ISL_18472175, EPI_ISL_18473491, EPI_ISL_18473552, EPI_ISL_18473557, EPI_ISL_18473565, EPI_ISL_18473584, EPI_ISL_18473600, EPI_ISL_18473608, EPI_ISL_18473617, EPI_ISL_18473635, EPI_ISL_18473684`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_33d1_b55240.json?label=id:node_3483621 image

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Branch 84

Defining Mutations: HK.19 > C2455T > G22927T(S:L455F), C23533T(S:N657) Query: C2455T, C22033A, G22927T, -G25606A Earliest seq: 2023-09-20 (EPI_ISL_18327665, SEA airport, travel history: China) Latest seq: 2023-10-06 (EPI_ISL_18454355, Yunnan China) Sampled Countries: China (7)

Genomes: `EPI_ISL_18327626, EPI_ISL_18327665, EPI_ISL_18454355, EPI_ISL_18475173-18475174, EPI_ISL_18481030, EPI_ISL_18481032`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice2_genome_14b93_98620.json?label=id:node_3515333 image

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Branch 85: Mostly with ORF6:N34K/C27303A

Defining Mutations: EG.5.1.1 > C7390T > G22927T(S:L455F) Query: C7390T, G13627A, G22927T Earliest seq: 2023-08-31 (EPI_ISL_18312335, South Korea) Latest seq: 2023-10-30 (EPI_ISL_18494555, Denmark) Sampled Countries: China (7: SC/3; HB/2; XJ/2), South Korea (4), Australia (2), Denmark (1), Spain (1)

Genomes: `EPI_ISL_18284798, EPI_ISL_18312335, EPI_ISL_18312767, EPI_ISL_18313150, EPI_ISL_18330217, EPI_ISL_18355417, EPI_ISL_18361365, EPI_ISL_18376681, EPI_ISL_18402975, EPI_ISL_18447796, EPI_ISL_18461975, EPI_ISL_18475119, EPI_ISL_18481228, EPI_ISL_18494555, EPI_ISL_18495106`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_25e0e_b6750.json?label=id:node_3492892 image

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Branch 86: many with S:N17T/A21612C

Defining Mutations: EG.5.1.1 > G25855T(ORF3a:D155Y) > G22927T(S:L455F) Query: A21612C, G22927T, G25855T Earliest seq: 2023-08-31 (EPI_ISL_18284769, Sichuan, China) Latest seq: 2023-10-24 (EPI_ISL_18458002, Kuala Lumpur, Malaysia) Sampled Countries: China (9: YN/6; SC/3), Malaysia (3), Japan (1)

Genomes: `EPI_ISL_18284769, EPI_ISL_18324153, EPI_ISL_18324208, EPI_ISL_18324235, EPI_ISL_18384546, EPI_ISL_18419659, EPI_ISL_18419662, EPI_ISL_18454181, EPI_ISL_18458002, EPI_ISL_18475350, EPI_ISL_18481259, EPI_ISL_18488097, EPI_ISL_18488110`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_372c6_bbb70.json?label=id:node_3488769 image

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Branch 87

Defining Mutations: EG.5.1 > C15960T > C16260T > G22927T(S:L455F), C24771T(S:A1070V), C25658T(ORF3a:T89I) Query: C15960T, C16260T, A18492G, G22927T Earliest seq: 2023-09-01 (EPI_ISL_18384575, Yunnan, China) Latest seq: 2023-10-27 (EPI_ISL_18493260, Alberta, Canada) Sampled Countries: China (5: SH/3; SX; YN), Canada (3: AB), South Korea (2)

Genomes: `EPI_ISL_18384575, EPI_ISL_18426071, EPI_ISL_18436785, EPI_ISL_18460945-18460946, EPI_ISL_18475132, EPI_ISL_18481223, EPI_ISL_18493260, EPI_ISL_18495087, EPI_ISL_18495466`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice95_genome_43bfd_a83e0.json?label=id:node_3517572 image

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Branch 88

⚠️ sibling to Branch 32 please check potential misplacement

Defining Mutations: EG.5.1.1 > T4579A > A4576T > G22927T(S:L455F) Query: A4576T, G13627A, G22927T Earliest seq: 2023-08-18 (EPI_ISL_18239385, South Korea) Latest seq: 2023-10-30 (EPI_ISL_18520721, Saitama, Japan) Sampled Countries: South Korea (39), Japan (2), USA (2, ex. Japan), China (1, ex. S. Korea)

Genomes: `EPI_ISL_18239385, EPI_ISL_18313064, EPI_ISL_18320761, EPI_ISL_18354110, EPI_ISL_18355244, EPI_ISL_18355256, EPI_ISL_18355270, EPI_ISL_18355539, EPI_ISL_18368435, EPI_ISL_18368571, EPI_ISL_18382929, EPI_ISL_18408987, EPI_ISL_18411143, EPI_ISL_18432570, EPI_ISL_18439431, EPI_ISL_18460891, EPI_ISL_18460981, EPI_ISL_18461196, EPI_ISL_18503870, EPI_ISL_18510989, EPI_ISL_18511173, EPI_ISL_18511218, EPI_ISL_18511236, EPI_ISL_18511259, EPI_ISL_18511379, EPI_ISL_18511388, EPI_ISL_18511531, EPI_ISL_18511534, EPI_ISL_18511636, EPI_ISL_18511644, EPI_ISL_18511659, EPI_ISL_18511666, EPI_ISL_18511675, EPI_ISL_18511683, EPI_ISL_18520721, EPI_ISL_18535535, EPI_ISL_18539100, EPI_ISL_18539189, EPI_ISL_18539430, EPI_ISL_18539531, EPI_ISL_18539554, EPI_ISL_18539681, EPI_ISL_18539751, EPI_ISL_18539824`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_2459b_3b16b0.json?f_userOrOld=uploaded%20sample&label=id:node_3488766

view from EG.5.1.1 > T4579A branch, sibling to Branch 32? 3288

details image

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Branch 89

Defining Mutations: EG.5.1.1 > C27406T(ORF7a:L5F) > G22927T(S:L455F) Query: C6541T, G13627A , G22927T, C27406T Earliest seq: 2023-08-11 (EPI_ISL_18145981, Hubei, China) Latest seq: 2023-10-18 (EPI_ISL_18487967, Henan, China) Sampled Countries: China (6: HA/2; HB/2; SC/2; BJ), South Korea (1)

Genomes: `EPI_ISL_18145981, EPI_ISL_18320871, EPI_ISL_18360327, EPI_ISL_18382216, EPI_ISL_18438321, EPI_ISL_18485262, EPI_ISL_18487967`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice16_genome_15d09_3ad150.json?label=id:node_3506957 image

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Branch 90

Defining Mutations: EG.5.1.1 > C13724T(ORF1a:A4487V), A25636T(ORF3a:N82Y) > T10750C, G22927T(S:L455F) Query: G13627A, C13724T, G22927T, -C5031T Earliest seq: 2023-08-22 (EPI_ISL_18272130, South Korea) Latest seq: 2023-10-19 (EPI_ISL_18451971, SEA airport, travel history: South Korea) Sampled Countries: South Korea (6), USA (2: ex. South Korea)

Genomes: `EPI_ISL_18272130, EPI_ISL_18376686, EPI_ISL_18376765, EPI_ISL_18451971, EPI_ISL_18460748, EPI_ISL_18488908-18488909, EPI_ISL_18492194`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_42b73_3bb260.json?label=id:node_3520099 image

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Branch 91

Defining Mutations: EG.5.1.1 > C22987T(S:A475A) > G22927T(S:L455F) > G19419A, G21974C(S:D138H) Query: G13627A, G19419A, G21974C Earliest seq: 2023-08-24 (EPI_ISL_18284675, Beijing, China) Latest seq: 2023-11-04 (EPI_ISL_18486471, Dublin, Ireland) Sampled Countries: China (6: SC/4; BJ; YN), Ireland (2), Greece (1)

Genomes: `EPI_ISL_18284675, EPI_ISL_18409255, EPI_ISL_18409302, EPI_ISL_18429520, EPI_ISL_18438109, EPI_ISL_18442759, EPI_ISL_18454352, EPI_ISL_18486471, EPI_ISL_18490986`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice2_genome_6555_3bdc60.json?label=id:node_3502929 image

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Branch 92

Defining Mutations: EG.5.1.1 > C629T(ORF1a:L122F) > A1168G > C22987T(S:A475A) > T595C, C20148T, G22927T(S:L455F) Query: A1168G, G22927T, C22987T Earliest seq: 2023-09-08 (EPI_ISL_18330247, Hubei, China) Latest seq: 2023-10-30 (EPI_ISL_18539359, South Korea) Sampled Countries: South Korea (5), Japan (2), China (1, HB), USA (1: CA)

Genomes: `EPI_ISL_18330247, EPI_ISL_18435755, EPI_ISL_18443954, EPI_ISL_18446528, EPI_ISL_18502023, EPI_ISL_18503555, EPI_ISL_18511230, EPI_ISL_18520709, EPI_ISL_18539359`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_6555_3bdc50.json?label=id:node_3498262 image

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Branch 93

Defining Mutations: EG.5.1 > G26051T(ORF3a:S220I) > G9269A(ORF1a:G3002S) > T1216C, A9034G, A12121T, A12519G(ORF1a:D4085G), G22927T(S:L455F) Query: G9269A, G22927T, G26051T Earliest seq: 2023-10-21 (EPI_ISL_18453659, South Australia) Latest seq: 2023-11-05 (EPI_ISL_18524643, Queensland) Sampled Countries: Australia (7: QLD/6; SA)

Genomes: `EPI_ISL_18453659, EPI_ISL_18489126, EPI_ISL_18501702, EPI_ISL_18501758, EPI_ISL_18524643, EPI_ISL_18524655, EPI_ISL_18524668`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice52_genome_199a5_39a640.json?label=id:node_3459700 image

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Branch 94

a sub-branch of #1074 proposed by @aviczhl2

Defining Mutations: EG.5.1.13 > _G670T_rev(ORF1a:R135S_rev)_ > T28861C > G8889A(ORF1a:R2875H) > C13381T > G22424T(S:A288S) > C25047T(S:P1162L) > G25855T(ORF3a:D155Y) > G22927T(S:L455F) Query: G8889A, C13381T, G22927T Earliest seq: 2023-10-10 (EPI_ISL_18486858, Temuco, Chile) Latest seq: 2023-11-26 (EPI_ISL_18582164, Ontario, Canada) Sampled Countries: Canada (14: ON/13; NS), Chile (3), USA (3: NY/2; PA)

Genomes: `EPI_ISL_18483588, EPI_ISL_18483657, EPI_ISL_18486858, EPI_ISL_18523437, EPI_ISL_18534577, EPI_ISL_18548162, EPI_ISL_18581551-18581554, EPI_ISL_18581688, EPI_ISL_18581705, EPI_ISL_18582159, EPI_ISL_18582162, EPI_ISL_18582164, EPI_ISL_18582914, EPI_ISL_18582921-18582922, EPI_ISL_18582983, EPI_ISL_18602138`

UShER: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_7d45_55cdd0.json?label=id:node_3474267 image

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Singlets

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Doublets

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Triplets

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Quadruplets

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Quintuplets

Fujian/FCDC-QZ08S024/2023|EPI_ISL_18145964|2023-08-18; England/CLIMB-CM7YJZ4C/2023|EPI_ISL_18392773|2023-10-05; Yunnan/YNCDC-3090/2023|EPI_ISL_18454344|2023-10-12; Yunnan/YNCDC-3139/2023|EPI_ISL_18488099|2023-10-12; Singapore/R78MR69/2023|EPI_ISL_18444918|2023-10-25; South_Korea/KDCA273761/2023|EPI_ISL_18535687|2023-10-31 and USA/MN-MDH-37408/2023|EPI_ISL_18510684|2023-11-01 EG.5.1.1 > C25578T > G22927T(S:L455F) [Query: C8320T, G22927T, C25578T, 5 seqs, 11/23]

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xz-keg commented 1 year ago

Branch 53 seems exploding.

FedeGueli commented 1 year ago

Branch 23 designated HK.2.1 via https://github.com/cov-lineages/pango-designation/commit/d75dabedbd433e944eeaee05222453dbda071cf1 milestone edited

FedeGueli commented 1 year ago

Branch 26 is now HK.11.1 via https://github.com/cov-lineages/pango-designation/commit/e268dbfb10735703aeec95cf82092020689f4f4d

FedeGueli commented 1 year ago

Branch 53 seems exploding.

@NkRMnZr plese propose Branch 53 when it reaches 35

xz-keg commented 1 year ago

@FedeGueli You can add multiple milestones and not fix everything to one milestone.

FedeGueli commented 1 year ago

@FedeGueli You can add multiple milestones and not fix everything to one milestone.

Thank you didnt know it would have worked with the automated code.

xz-keg commented 1 year ago

Multiple Canadian clusters bring Branch 35 to 29 seqs.

xz-keg commented 1 year ago

Thank you didnt know it would have worked with the automated code.

It would work.

NkRMnZr commented 1 year ago

Branch 15 transferred to cov-lineages/pango-designation#2340 Branch 17 transferred to cov-lineages/pango-designation#2341 Branch 27 transferred to cov-lineages/pango-designation#2342

FedeGueli commented 1 year ago

Thx @ryhisner who spotted that Branch 48 jumped to 34 gaining further N:229R and S:G1267R in an australian branch, i suggest to propose it.

Schermata 2023-10-21 alle 09 13 17 https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_5f61d_377fa0.json?label=id:node_3467514

FedeGueli commented 1 year ago

Branch 15 transferred to cov-lineages/pango-designation#2340 Branch 17 transferred to cov-lineages/pango-designation#2341 Branch 27 transferred to cov-lineages/pango-designation#2342

Thank you

xz-keg commented 1 year ago

There seems to be a new EG.5.1.6+Flip branch, first under EG.5.1.6.

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice55_genome_6448_722340.json?gt=S.455F&label=id:node_11028103

image (Edited): Query: A15270T ,T877C samples 4 (Canada) Defining mutations: EG.5.1.6>Orf8:R115C (C28236T) > C16092T > C10969T > ORF1a:E87D (G526T) > C23380T >Orf1a:I4074V (A12485G) >T877C, Orf1b:E601D(A15270T), S:L455F (G22927T)

xz-keg commented 1 year ago

EG.5.1 > A3210G(ORF1a:D982G) > G26227T(TRS of Envelope), G26888A, C28720T(TRS of ORF9c) > T8909C, T21201C, G22927T(S:L455F), A23702T(S:I714L), A29221G, C29774T, C29803T [Query: A3210G, G22927T, G26227T, 2 seqs, 09/14]

This one is 14 now.

Editing here instead of posting(fed): The tree now changed and T21201C, A23702T(S:I714L), A29221G, C29774T, C29803T should be excluded from the defining mutations :https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_3f074_790990.json?label=id:node_3425846 Schermata 2023-10-24 alle 11 44 26 So the new defining of putative "Branch 65" should be : EG.5.1 > A3210G(ORF1a:D982G) > G26888A >G26227T, C28720T > T8909C> G22927T(S:L455F)

FedeGueli commented 1 year ago

There seems to be a new EG.5.1.6+Flip branch, first under EG.5.1.6.

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice55_genome_6448_722340.json?gt=S.455F&label=id:node_11028103

image

@NkRMnZr this should become Branch 64

FedeGueli commented 1 year ago

EG.5.1 > A3210G(ORF1a:D982G) > G26227T(TRS of Envelope), G26888A, C28720T(TRS of ORF9c) > T8909C, T21201C, G22927T(S:L455F), A23702T(S:I714L), A29221G, C29774T, C29803T [Query: A3210G, G22927T, G26227T, 2 seqs, 09/14]

This one is 14 now.

This should become Branch 65 @NkRMnZr

FedeGueli commented 1 year ago

Tell me when added i will remove the comments

@aviczhl2 i have edited your commments not to drive further crazy @NkRMnZr

NkRMnZr commented 1 year ago

10-26

Adding Branch 64 and 65 thanks to @aviczhl2 and @FedeGueli; Adding Branch 66 from former triplet; Adding Branch 67, a quintuplet from Singapore; Adding Branch 68 from former quintuplet. Adding Branch 69 from former triplet

Branch 24, 35, 42 almost reach 50;

FedeGueli commented 1 year ago

Thank you propose everything is 50.

xz-keg commented 1 year ago

New branch on EG.5.1.3 on Orf8:I47V branch , 6 seqs

query: C3608A,C18261,G22927T,28032

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice56_genome_2e6f5_c6c300.json?c=gt-S_455&gmax=25384&gmin=21563&label=id:node_3458430

image

FedeGueli commented 1 year ago

New branch on EG.5.1.3 on Orf8:I47V branch , 6 seqs

query: C3608A,C18261,G22927T,28032

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice56_genome_2e6f5_c6c300.json?c=gt-S_455&gmax=25384&gmin=21563&label=id:node_3458430

image

Branch 74 now

FedeGueli commented 1 year ago

thank you nkrmnzr and @aviczhl2 great work.

NkRMnZr commented 1 year ago

Branch 24 transferred to cov-lineages/pango-designation#2353 Branch 35 transferred to cov-lineages/pango-designation#2354 Branch 42 transferred to cov-lineages/pango-designation#2355

FedeGueli commented 1 year ago

Branch 24 transferred to cov-lineages/pango-designation#2353 Branch 35 transferred to cov-lineages/pango-designation#2354 Branch 42 transferred to cov-lineages/pango-designation#2355

Thank you outstanding work!

FedeGueli commented 1 year ago

Branch 77 seems fast. ORF1b:A1643V in Branch 78 is a known mutation: it popped up in an undesignated side branch of AY.41 (sibling to AY.103) that did very bad in south eastern Europe at the end of summer 2021

FedeGueli commented 1 year ago

Branch 24 designated HK.20 and HK.20.1 ( starting with S:G482R) https://github.com/cov-lineages/pango-designation/commit/71cf97b211299abf8f997396b40419285016b435

xz-keg commented 1 year ago

New branch EG.5.1.1+G1274T(Orf1a:V337F)+S:L455F(22927T)

6 seqs but already has an additional level of S:256L

image

NkRMnZr commented 1 year ago

New branch EG.5.1.1+G1274T(Orf1a:V337F)+S:L455F(22927T)

6 seqs but already has an additional level of S:256L

image

NkRMnZr commented 1 year ago

Branch 48 transferred to cov-lineages/pango-designation#2360

FedeGueli commented 1 year ago

Both Branch 80 and 81 +1 today both of them looking fast.

FedeGueli commented 12 months ago

Branch 13 now reached 49 one of the two samples from Singapore was from a traveller from India please propose it: Schermata 2023-11-08 alle 01 01 27 https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice15_genome_test_2d7e5_a33d70.json?c=userOrOld&label=id:node_3501029

xz-keg commented 12 months ago

New branch

EG.5.1.1+N:T362I+Orf1a:P193S,Orf3a:T175I,S:L455F

https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice23_genome_35be7_ad9240.json?label=id:node_3483620

image

NkRMnZr commented 12 months ago

Branch 13 transferred to cov-lineages/pango-designation#2364 Branch 51 transferred to cov-lineages/pango-designation#2365 Branch 53 transferred to cov-lineages/pango-designation#2366

FedeGueli commented 12 months ago

Thank you great job!

FedeGueli commented 12 months ago

Branch 46 + S:L452Q is now dsignated HK.22

FedeGueli commented 11 months ago

Branch 11 now has 79 please propose it.

Just set new threeshold to be proposed at 80 seqs. while exceptions are possible if something fast will emerge

FedeGueli commented 11 months ago

Branch 11 now has 79 please propose it.

scratch i missed the new query still 37 .

FedeGueli commented 11 months ago

Branch 54 over 50 now.

FedeGueli commented 11 months ago

Branches 63&64&66&67&68&69&76&78 seem fast

ryhisner commented 11 months ago

To me, branch 28 deserves to be moved to the main Pango page. There are lots of interesting branches there, and a really interesting sequence from Shanghai just showed up as well—EPI_ISL_18518361. The one branch has C26681T, the synonymous mutation in M that is also in BA.2.86 and many other sequences/lineages of interest.

M:K15Q is an A->C nuc mutation and N:T166R is C->G. These are rare nuc mutations, and I don't think they happened by accident.

FedeGueli commented 11 months ago

To me, branch 28 deserves to be moved to the main Pango page. There are lots of interesting branches there, and a really interesting sequence from Shanghai just showed up as well—EPI_ISL_18518361. The one branch has C26681T, the synonymous mutation in M that is also in BA.2.86 and many other sequences/lineages of interest.

M:K15Q is an A->C nuc mutation and N:T166R is C->G. These are rare nuc mutations, and I don't think they happened by accident.

Thank you @ryhisner lineages that reach 50 seqs will be proposed and B28 is 55 so it will be proposed as soon as @NkRMnZr will update this issue. I agree with you i found myself in the Branch 28 tree and saying wow.

FedeGueli commented 11 months ago

To me, branch 28 deserves to be moved to the main Pango page. There are lots of interesting branches there, and a really interesting sequence from Shanghai just showed up as well—EPI_ISL_18518361. The one branch has C26681T, the synonymous mutation in M that is also in BA.2.86 and many other sequences/lineages of interest. M:K15Q is an A->C nuc mutation and N:T166R is C->G. These are rare nuc mutations, and I don't think they happened by accident.

Thank you @ryhisner lineages that reach 50 seqs will be proposed and B28 is 55 so it will be proposed as soon as @NkRMnZr will update this issue. I agree with you i found myself in the Branch 28 tree and saying wow.

@NkRMnZr please propose it, it has the S:A475V branch highlighted as quadruplet in the multiple EG.5.1 +475V issue: https://github.com/sars-cov-2-variants/lineage-proposals/issues/978

Schermata 2023-11-18 alle 17 47 32 https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_56bc7_8e7230.json?label=id:node_3492685

FedeGueli commented 11 months ago

There maybe another EG.5.1.3 branch with S:L455F Defining mutations: EG.5.1.3 >> S:T874I(C24183T) > S:L455F (G22927T) https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_28083_f2c180.json?c=userOrOld&label=id:node_11125060 Schermata 2023-11-23 alle 11 49 29 Query:

The last two UK samples have S:T874I reverted and gained instead S:T22N , they cluster with a couple of GBW samples from South Korea.

Unsure if it could help with this uncertain placement but at least i put here if someone else finds it.

G28871A,G1085T catches the 2 GBW samples and the 2 Uk sample. could serve as control query to get an Usher in future for it.

FedeGueli commented 11 months ago

New triolet EG.5.1.3 from Australia EG.5.1.3 > C1057T > G18462A > ORF1a:L2105F (C6578T) > S:L455F (G22927T), C26058T, T27210C

https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_43dec_f43540.json?c=userOrOld&label=id:node_3548625 Schermata 2023-11-23 alle 13 27 28

FedeGueli commented 11 months ago

Branch 55 designated HK.24.1 via https://github.com/cov-lineages/pango-designation/commit/77596389b8d6291450be40a5b8a7c1701c9e5309

FedeGueli commented 11 months ago

Branch 15 is now HK.23.1 and HK.23.1.1 via https://github.com/cov-lineages/pango-designation/commit/b47c3ca2d6369c236951efde3b954e9ac022e5b7

FedeGueli commented 11 months ago

Branch 73 is now stemming out of HK.28

FedeGueli commented 11 months ago

Branch 76 parental lineage is now HK.30

FedeGueli commented 11 months ago

Branch 12 is now EG.5.1.17 via https://github.com/cov-lineages/pango-designation/commit/5a8103c3bf593a0b0e238b354488fed0e9c07e4b

FedeGueli commented 11 months ago

EG.5.1.18 is now the parental of Branch 93

FedeGueli commented 11 months ago

Branch 33 now designated EG.5.1.19 via https://github.com/cov-lineages/pango-designation/commit/0807c239597f9ab2d4bd86f7c789508877643be6