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Dear developers,
I am running SigProfilerTopography and despite providing sbs_probabilities it runs in the aggregated mutations mode, i.e., the figures for the individual signatures are not create…
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Hello,
Thanks for a great tool! I have been using it to randomize the position of mutations in samples while controlling for mutational signatures. However, I have noticed that I am not getting the…
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Dear AlexandrovLab people,
good afternoon and I hope my message reaches you well !! I would like to ask a particular question for the generation of CN signatures implementning the useful SigProfile…
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Hi Burçak,
Can you please help me answer some questions about your great program...
What do these parameters do?
- epigenomics_dna_elements
- mutation_annotation_integration
- sample_based
-…
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It seems like our frontend and backend are running different local db test sets, see:
[current frontend localdb tests](https://app.circleci.com/pipelines/github/cBioPortal/cbioportal-frontend/11610/w…
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Integrate deconstructSigs into package for investigation of mutational signatures on a per-sample level.
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hi. can i use a short genome region to extract signatures with this tool? just like 3kb.
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Hi
Sorry
I am trying to find mutational signature but I am getting error
Can you help please?
```
> laml.tnm = trinucleotideMatrix(maf = laml, prefix = 'chr', add = FALSE, ref_genome = "B…
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Hi,
Thank you for the development and maintenance of this great tool! I've using the tool on a dataset for selected variants. Maybe because of selected variants, the cosine similarities for some p…
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Hello,
I have a VCF file and I would like to know:-
1) Which among the 96SBS is more prominent in the current VCF data based on the classification of SBS by the COSMIC database?
2) Plots of speci…