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Good morning, I am new to PBPK modeling, but have extensive experience with pharmacodynamic kinetic modeling. Are there any resources available that help in decision making for parameter modification …
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Dear OSP-community,
We have recently been working on a mechanistic PBPK/PD model to study dabigatran reversal, which includes the reversal of dabigatran by hemodialysis and its antidote idarucizuma…
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Dear all,
I would like to contribute and deposit the first version of our Cabozantinib PBPK model. Would this be possible?
name of your model: Cabozantinib
short description of the model repo…
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Hi,
I tried searching for Rosuvastatin (RSV) PBPK model using PKSim platform but could not find anything.
Did anyone worked on this model using PKSim?
As most of the literature that I reffered t…
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Hello, everyone. I have a question for age dependent PBPK. In the tutorial, three pediatric groups were set as: 0-0.1 years (newborn), 0.1-2 years (toddlers), and 2-6 years (preschool). I think this …
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Hello All,
Can any one help me with sharing the Azithromycin PK SIM project file, iam referring to
https://pdfs.semanticscholar.org/c58c/83cfabd61a94bc4ed53e7e1a8b6a35557d6f.pdf
link above
Author…
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Dear all,
We are happy to share our carefully developed metformin and cimetidine PBPK models. The corresponding manuscript, including comprehensive documentation, has been accepted for publication …
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Dear OSP-community,
We have recently been working on PBPK modeling of fentanyl in adults and pediatrics. First, an adult PBPK model has been thoroughly developed, which is able to predict fentanyl …
LkKov updated
3 years ago
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Dear OSP-community,
We have recently been working on PBPK modeling of buprenorphine in pediatrics. First, an adult PBPK model has been thoroughly developed, which is able to predict buprenorphine a…
LkKov updated
3 years ago
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Hi,
I would like to know where I can find the equations for each physiological parameter. For example, equations that describe organ volume as a function of age, weight, gender, etc. Also, where ca…