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Hi, I want to apply estimate CNV mutational signatures based on CNS files (a sample a file) generated by CNVkit.
Do you have an idea of how to do this?
Thank you!
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Dear SigProfilerExtractor developers,
I've been using your tool with no problems until now.
I'm trying to get some mutational signatures from whole-exome sequencing (WES) data
I used Mutect2, Lanc…
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Hi,
I noticed that there were new signatures that were defined and put on the COSMIC website. I want to compute scores for one of the new signatures (SBS88), but I have exome data only. There is a …
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sigProfilerExtractor() (v1.1.3) cannot handle vcf files which contain "," in ALT column.
(NMF analyses is not executed if one of vcf files contains "," in ALT column.
Cf. sigProfilerExtractor() (v1.…
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Hi!
Looking forward to giving this tool a trial. What did you use to derive the initial snv trees? Would treeomics be adequate?
Thanks,
Michael
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https://mp.weixin.qq.com/s/eZ8fVwg8n71Y4oWoidquUg
ixxmu updated
2 years ago
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Dear authors,
I was very excited to find out that v3 has support for DBS and Indel- however my goal is to ultimately calculate the cosine similarity between a mutational profile and all types of C…
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Hello,
I'm working on mutational signature analysis (I also put a picture down here), so I'm wondering if we can get these two kinds of data from megalodon: 1) exact total number of SNPs in each sa…
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I started a test run with `make test` but the log was greater than my terminal history. Here is the end of it, along with a few other commands showing the branch/commit and variable set.
```
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#### What analysis module should be updated and why?
[`mutational-signatures`](https://github.com/AlexsLemonade/OpenPBTA-analysis/tree/master/analyses/mutational-signatures)
#### Why should the mo…