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Looking at this issue here
https://github.com/Open-Systems-Pharmacology/Forum/issues/64
I think a lot of people could benefit from a simple CLI that would allow them to run the batch tool in a sl…
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Hi, all
I am following a simulation in one paper (Manuel Ibarra, Cristian Valiante, Patricia Sopeña, et al. Integration of in vitro biorelevant dissolution and in silico PBPK model of carvedilol t…
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Hello everyone, I would like to know how to add the volume distribution parameter, this parameter related to the compound.
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... as we already have for the Matlab Toolbox, but extended, so we can "substitute" species as well ;-)
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Greetings All!
I am new to PK-Sim and MoBi. I was able to complete part up to simulation and then parameter identification.
Could someone please guide me how to perform population PK and then a vir…
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I have been trying to build a PBPK model for asenapine in rats, since there are no readily available databases for rats as there are for humans, can you please suggest me ways to obtain relative expre…
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Hello all,
It is a question about equation 2 in paper "Christoph et al. 2018 A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim".
![image](https:…
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[GFR_ontogeny_report_JS.pdf](https://github.com/Open-Systems-Pharmacology/OSP-Qualification-Reports/files/4761258/GFR_ontogeny_report_JS.pdf)
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Hi, all
I am doing the PBPK model on andrographolide and encounter some problems related to permeability and transporters. The experimental permeablity is cited from doi.org/10.1002/jps.22693.
![ima…
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Hi! I have couple of questions.
1) Where can I find Kp scalar (ratio of drug concentration in tissue and plasma) to optimize Kp values for various organs?
2) Where is the place to enter Vss value …