-
Hi, i have the same problem.
I want to perform rare variants (MAF < 1%) analysis in Regenie, and have tried many times to follow your earlier advice to others, but still encounter the s…
-
Hi Joelle,
I hope you're well. I'd be grateful if you could please help me with a problem in gene based burden testing using the --rgc-gene-p command.
The output to the console reports no issue…
-
This is the issue from the TODO comment at:
https://github.com/linebender/xilem/blob/7be4dd2a2f8bf820fc19a3af2a00600d05e4d4c7/masonry/src/widget/image.rs#L94-L97
In particular, the current layout …
-
We are using DROP in undiagnosed rare disease patient cohort. If I understand correctly, the underlying assumption of DROP is that all samples were taken randomly from a population, regardless of the …
-
Hello,
I tried to use geva to estimate the ages of some rare variants but got empy output. When checking with the log file, I noticed it saying Position not viable. I am not sure what that means an…
-
The program when invoked using `--dosage` or `--dosageOptionFile` attempts to calculate 3 parameters c1, c2, c3 in the block of code below (the if(use_dosage) condition will be true). This looks like …
-
We moved to rankscore, but raw scores are used in ACMGv4 in PP3_supporting
Check out if any others are used
We should also run eg REVEL as a tool instead of dbNSFP
If not on the short variants then…
-
I noticed some potentially unintended behavior with Fluttering Echo while testing mineshaft mods last night. This is for Old Legends v4.0.0 in Fabric 1.20.4.
If enchanted with Silk Touch, Flutterin…
-
I'm doing an interaction test in the UK Biobank between a particular candidate gene's rare-variant burden (100 carriers out of 500,000) and each other gene's rare-variant burden. (I specified the cand…
-
### Need
As a geneticst, despite not having a matching normal sample for germline filtering, I want to be sure that all somatic variants I am interpreting are true somatic variants, and not germlin…