-
Dear All,
I am just wondering why changing the gastric pH in the Itraconazole model -PK-Sim template model- doesn't show any changes in the plasma profile curve or the PK parameters, although this dr…
-
Hello,
Is there a way to switch to blood flow limited/perfusion limited models for drug kinetics in PK-Sim for small molecules model? By default it uses permeability limited type of model when no l…
-
Dear all
I've been testing PKSim for the last months and becoming a fan!
For simulating clinical trials, however, it would be interesting if inter-occasion (or intra-subject) variability could be se…
nmens updated
6 years ago
-
If you have 30% bound, will the administered dose be used as input as 100% or reduced by 30%? I cannot see the differential equations in each organ compartment to help me understand that. Thank you ve…
-
Consider my example from #46 .
The described model is loaded into R and no parameters are initialized:
```
library(MoBiToolboxForR, quietly=TRUE)
testXML = ".\\QC_R\\testSim.xml"
DCI_Info_tes…
-
I am trying to build a PBPK model for meropenem.
70% of the drug is excreted unchanged in urine. I would like to know if I am missing anything?
Thanks in advance.
kind regards
Mouli
[Meropenam.pd…
-
[Meropenam.pdf](https://github.com/Open-Systems-Pharmacology/PK-Sim/files/1398398/Meropenam.pdf)
I am trying to build a PBPK model for meropenem.
70% of the drug is excreted unchanged in urine. I w…
-
I followed the suggested workflow documented in this forum to add a Tumor container by importing a saved representative Organ.
The Organ did not import successfully in that although all the neigh…
ghost updated
7 years ago
-
with PK-Sim® and MoBi® for Quantitative Systems Pharmacology
-> with PK-Sim® and MoBi® for PBPK and Quantitative Systems Pharmacology
or
-> with PK-Sim® and MoBi® for Quantitative Systems Pharmacol…
-
Dear all,
as far as I know PK-sim predicts the pH-dependent solubility from a given solubility at a reference pH and the pKa values of the compounds. However sometimes you have the luxury of measur…