-
Hi,
I've successfully replicated results using some of the ldscores from the most recent biorxiv paper for partitioned heritability (Heritability enrichment of specifically expressed genes identifi…
-
In the analytics discussion we have been discussing about how to handle summary statistics for a given variable in a study (e.g. heritability, CV, Wald p-value, etc.)
One option would be to define an…
-
Hi,
We are currently running a partitioned heritability analysis with our annotation and 10 GWAS. Some of them don't include the frequency of the SNP, and even though I have observed that this inf…
-
@hsun3163 please fill it up.
-
Hello, esteemed LDSC team,
I would like to know how to calculate partitioned genetic correlations. Prior to this, I have already completed the analysis of partitioned heritability,This will be of gr…
-
Prompting for non-conformable arguments when using MRAPSS::est_paras.
Are the matrices multiplied in the correct dimension and order?
here is the code and output to repeat the problem.
```{r}…
-
Need to find a way to quantify the improvement of power via heritability. The number of significant gene could works, but variance explained seems to be a better indicator.
Maybe utmost paper have…
-
Dear ldsc team,
I am running -rg on 11 traits with conversion to the liability scale by including population and sample prevalences. When inspecting the output file, I observed a discrepancy betwee…
-
Could you please comment: if you have low ratio values (and also low h2 for one of the phenotypes) for two continuous phenotypes (both summary statistics are GC corrected), can the genetic correlation…
-
Hi, sorry for so many question,
but I am really interested in your method.
I wanted to double check with you the intercept you refer to in the paper and make sure my interpretation is correct.
belo…