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## Problem
I need help specifying the mixed logistic growth models for the `alda::cognitive_growth` experiment covered in Chapter 6, section 6.4, with `nlme::nlme()` and/or `lme4::nlmer()`. I'm not…
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While linear mixed effect models are supported, nonlinear mixed effects models like `nlme` are not supported at this time. I'm unsure this is in scope or out of scope for this project.
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All PRs and attempts to add general nonlinear model (not with link, single index) have stalled so far.
(I was looking again at outlier robust estimation of nonlinear mean functions `y = f(x, theta) +…
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MOSEK rejects models that contain a quadratic objective and a quadratic constraint:
```
var x {1..7} >= 0;
minimize qobj: sum {j in 1..7} x[j]^2;
subj to qconstr: sum {j in 1..7} x[j]^2 = the obje…
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I have read with interest your 2017 paper ‘Estimation of Extended Mixed Models Using Latent Classes and Latent Processes: The R Package lcmm’ (https://doi.org/10.48550/arXiv.1503.00890), and would lik…
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NONMEM data sets usually contain information about dosing events (dose + dosing time), formulation GFR, and a lot of biometric information of the study subjects, etc.. It would be great to enable PK-S…
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e.g Logit( x b + e) where e is an unobserved random term
Jensen's inequality bites again.
E(y | x) is not Logit(x b) (or expit ?)
Wooldridge on control function explains average structural fun…
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(mainly to get started with an issue and to park two links)
https://stats.stackexchange.com/questions/252317/similarities-and-differences-between-irt-model-and-logistic-regression-model
https://st…
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Can't run with anything but REML = FALSE, finescale = FALSE, bias_correct = FALSE
Also, the random effects vector changes when this happens (see: https://github.com/James-Thorson-NOAA/VAST/issues/2…
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**Which problem would you like to address? Please describe.**
Currently, PEtab does not allow to express nonlinear mixed effects models (i.e containing fixed (population) and random (patient-specific…