Open-Systems-Pharmacology OSP-based-publications-and-content issues

Open-Systems-Pharmacology / OSP-based-publications-and-content

Publications of all kind based on the Open Systems Pharmacology Suite

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Recent Applications Of Physiologically Based Pharmacokinetic Modeling To Assess The Toxicity Of Mixtures: A Review

#457 AndreDlm opened 1 year ago
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Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation

#456 AndreDlm opened 1 year ago
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Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules

#455 AndreDlm opened 1 year ago
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Intravenous or Oral Acetaminophen for Analgesia After Cesarean Section: Exposure Drives Pain Relief

#454 Yuri05 opened 1 year ago
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PBPK MODELING OF A NARROW THERAPEUTIC INDEX DRUG AND APPLICATION IN PREDICTING DOSE ESCALATION SCENARIOS, FOOD EFFECT, DDI AND SPECIAL POPULATION.

#453 Yuri05 opened 1 year ago
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Physiologically Based Pharmacokinetic Modeling of Tacrolimus for Food-Drug and CYP3A Drug-Drug-Gene Interaction Predictions

#452 Yuri05 opened 1 year ago
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Physiologically-Based Pharmacokinetic model for Ciprofloxacin in children with complicated Urinary Tract Infection

#451 Yuri05 opened 1 year ago
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Ethambutol disposition in humans: Challenges and limitations of whole-body physiologically-based pharmacokinetic modelling in early drug development

#450 Yuri05 opened 1 year ago
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Integration of evidence to evaluate the potential for neurobehavioral effects following exposure to USFDA-approved food colors

#449 Yuri05 opened 1 year ago
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Strong Pharmacokinetic Drug-Drug Interactions With Drugs Approved by the US Food and Drug Administration in 2021: Mechanisms and Clinical Implications

#448 Yuri05 opened 1 year ago
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The feasibility of physiologically based pharmacokinetic modeling in forensic medicine illustrated by the example of morphine

#447 Yuri05 opened 1 year ago
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Pitfalls of using numerical predictive checks for population physiologically-based pharmacokinetic model evaluation

#446 Yuri05 opened 1 year ago
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Physiologically Based Pharmacokinetic Modeling for Trimethoprim and Sulfamethoxazole in Children

#445 Yuri05 opened 1 year ago
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Comprehensive Parent-Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies

#444 Yuri05 opened 1 year ago
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Enhancing Atorvastatin In Vivo Oral Bioavailability in the Presence of Inflammatory Bowel Disease and Irritable Bowel Syndrome Using Supercritical Fluid Technology Guided by wbPBPK Modeling in Rat and Human

#443 Yuri05 opened 1 year ago
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Synthesis and inverse virtual screening of new bi-cyclic structures towards cancer-relevant cellular targets

#442 Yuri05 opened 1 year ago
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Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A

#441 Yuri05 opened 1 year ago
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Using a Mathematical Modeling To Simulate Pharmacokinetics and Urinary Glucose Excretion of Luseogliflozin and Explore the Role of SGLT1/2 in Renal Glucose Reabsorption

#440 Yuri05 opened 1 year ago
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A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug–Drug Interaction Perpetrators

#439 Yuri05 opened 1 year ago
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Quantitative Characterization of Clinically Relevant Drug-Metabolizing Enzymes and Transporters in Rat Liver and Intestinal Segments for Applications in PBPK Modeling

#438 AndreDlm opened 1 year ago
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Physiologically based pharmacokinetic modeling to predict OAT3-mediated drug-drug interactions of meropenem in varying stages of chronic kidney disease

#437 Yuri05 opened 1 year ago
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A physiologically based pharmacokinetic model for [⁶⁸Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients

#436 Yuri05 opened 1 year ago
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Physiologically-Based Pharmacokinetic Modeling of Tenofovir Disoproxil Fumarate in Pregnant Women

#435 AndreDlm opened 1 year ago
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Data-Driven Approaches Used for Compound Library Design for the Treatment of Parkinson’s Disease

#434 JanSchlender opened 1 year ago
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Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species

#433 AndreDlm opened 1 year ago
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Development of a Physiologically Based Pharmacokinetic Model for Tegoprazan: Application for the Prediction of Drug-Drug Interactions with CYP3A4 Perpetrators

#432 AndreDlm opened 1 year ago
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Considering developmental neurotoxicity (DNT) in Vitro data for human health risk assessment using physiologically-based kinetic (PBK) modeling: deltamethrin case study

#431 AndreDlm opened 1 year ago
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Physiologically based pharmacokinetic modelling and simulation to predict the plasma concentration profile of schaftoside after oral administration of total flavonoids of Desmodium styracifolium

#430 JanSchlender opened 1 year ago
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Bridging the Gap between Food Effects under Clinical Trial Conditions and Real Life: Modeling Delayed Gastric Emptying of Drug Substances and Gastric Content Volume Based on Meal Characteristics

#429 JanSchlender opened 1 year ago
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Prediction of Drug–Drug–Gene Interaction Scenarios of (E)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling

#428 JanSchlender opened 1 year ago
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Predicting the correct dose in children: Role of computational Pediatric Physiological-based pharmacokinetics modeling tools

#427 JanSchlender opened 1 year ago
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In vitro-in vivo extrapolation of bexarotene metabolism in the presence of chronic kidney disease and acute kidney injury in rat using physiologically based pharmacokinetic modeling and extrapolation to human

#426 JanSchlender opened 1 year ago
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Verifying in vitro-determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically based pharmacokinetic modelling

#425 AndreDlm opened 1 year ago
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Physiologically Based Pharmacokinetic Modeling of Omalizumab to Predict the Pharmacokinetics and Pharmacodynamics in Pediatric Patients

#424 AndreDlm opened 1 year ago
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Physiologically-based pharmacokinetic modeling of remdesivir and its metabolites in pregnant women with COVID-19

#423 AndreDlm opened 1 year ago
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Application of PBPK modeling in predicting maternal and fetal pharmacokinetics of levetiracetam during pregnancy

#422 AndreDlm opened 1 year ago
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A Physiologically-Based Pharmacokinetic Model of Ruxolitinib and Posaconazole to Predict CYP3A4-Mediated Drug–Drug Interaction Frequently Observed in Graft versus Host Disease Patients

#421 AndreDlm opened 1 year ago
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Application of Physiologically Based Pharmacokinetic Modeling to Predict Maternal Pharmacokinetics and Fetal Exposure to Oxcarbazepine

#419 AndreDlm opened 1 year ago
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Pharmacogenetic variability and the probability of site of action target attainment during tuberculosis meningitis treatment: A physiologically based pharmacokinetic modeling and simulations study

#418 JanSchlender opened 1 year ago
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Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Labetalol in Healthy and Diseased Populations

#417 AndreDlm opened 1 year ago
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Mathematical and Pharmacokinetic Approaches for the Design of New 3D Printing Inks Using Ricobendazole

#416 JanSchlender opened 1 year ago
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A generic avian physiologically-based kinetic (PBK) model and its application in three bird species

#415 JanSchlender opened 1 year ago
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Prediction for optimal dosage of pazopanib under various clinical situations using physiologically based pharmacokinetic modeling

#414 JanSchlender opened 1 year ago
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Application of physiologically-based pharmacokinetic model approach to predict pharmacokinetics and drug-drug interaction of rivaroxaban: A case study of rivaroxaban and carbamazepine

#413 JanSchlender opened 1 year ago
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The investigation of the complex population-drug-drug interaction between ritonavir-boosted lopinavir and chloroquine or ivermectin using physiologically-based pharmacokinetic modeling

#412 AndreDlm opened 1 year ago
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Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil

#411 AndreDlm opened 1 year ago
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Patient-specific in vitro drug release testing coupled with in silico PBPK modeling to forecast the in vivo performance of oral extended-release levodopa formulations in Parkinson's disease patients

#410 AndreDlm opened 2 years ago
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The Use of Pregnancy Physiologically Based Pharmacokinetic Modeling for Renally Cleared Drugs

#409 AndreDlm opened 2 years ago
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A multi-model approach to predict efficacious clinical dose for an anti-TGF-β antibody (GC2008) in the treatment of Osteogenesis Imperfecta (OI)

#408 JanSchlender opened 2 years ago
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Physiologically based pharmacokinetic (PBPK) modeling of lornoxicam: Exploration of doses for CYP2C9 genotypes and patients with cirrhosis

#407 JanSchlender opened 2 years ago
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