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Publications of all kind based on the Open Systems Pharmacology Suite
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Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models
#507
AndreDlm
opened
1 year ago
0
Physiologically Based Pharmacokinetic Modeling to Simulate CYP3A4-Mediated Drug-Drug Interactions for Pyrotinib
#506
Yuri05
opened
1 year ago
0
Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary
#505
AndreDlm
opened
1 year ago
0
Physiologically-Based Pharmacokinetic Modelling for Single and Multiple Dosing Regimens of Ceftriaxone in Healthy and Chronic Kidney Disease Populations: A Tool for Model-Informed Precision Dosing
#504
AndreDlm
opened
1 year ago
0
Informing a Comprehensive Risk Assessment of Infant Drug Exposure From Human Milk: Application of a Physiologically Based Pharmacokinetic Lactation Model for Sotalol
#503
JanSchlender
opened
1 year ago
0
Predicting the effect of different folate doses on [⁶⁸Ga]Ga-PSMA-11 organ and tumor uptake using physiologically based pharmacokinetic modeling
#502
Yuri05
opened
1 year ago
0
Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict the Pharmacokinetics of Irbesartan in Different CYP2C9 Genotypes
#501
Yuri05
opened
1 year ago
0
A physiologically based pharmacokinetic model of cefepime to predict its pharmacokinetics in healthy, pediatric and disease populations
#500
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: PBPK model-based extrapolation from adults to children to predict furosemide oral solution bioavailability
#499
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Comparison of monoclonal antibody disposition predictions between different PBPK platforms
#498
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Physiologically based pharmacokinetic (PBPK) modeling of the oral absorption of 5-flucytosine to support further development of a sustained-release formulation for the treatment of cryptococcal meningoencephalitis
#497
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Unravelling the complex inhibition network of voriconazole and its metabolites using a middle-out PBPK approach
#496
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Development of a physiological-based pharmacokinetic model for sacubitril and its metabolite
#495
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Physiologically Based Pharmacokinetic (PBPK) Modelling to Predict Human Milk Exposure to medicines: a contribution from the ConcePTION Project
#494
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Mechanistic modelling of bioavailability and local immunogenicity after subcutaneous administration within the Open Systems Pharmacology framework
#493
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Developing a PBPK/PD/Tox Modelling Framework for NANOBODY® Drug Conjugates
#492
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: An Integrated PBPK-Quantitative Systems Pharmacology Model for Statins to Assess the Variability and Implications of Transporter-Mediated Distribution
#491
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Physiologically Based Pharmacokinetic Modeling of Imatinib and Its Main Metabolite for Drug–Drug Interaction Predictions
#490
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Physiologically Based Pharmacokinetic Modeling of Dasatinib to Describe Enzyme-Mediated and pH-Dependent Drug–Drug Interaction Scenarios
#489
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Implementation of Oral Drug Absorption in Older Adults in the Physiologically Based Pharmacokinetic (PBPK) Modelling Platforms
#488
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Physiologically-based pharmacokinetic modelling of recombinant factor IX Fc fusion protein (rFIXFc) and recombinant FIX (rFIX) to characterize extravasation and binding to type IV collagen
#487
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Using PBPK Modeling to support an adaptive “First-in-Pediatric” trial design of Sonlicromanol for the treatment of Primary Mitochondrial Disease
#486
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Development of a Physiological-Based Pharmacokinetic Model for Ritonavir: Unraveling its Triphasic Effects as CYP3A Inhibitor, CYP3A Inducer, and Pgp Inhibitor.
#485
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: R framework for reproducible and quality-controlled modeling and simulation with the Open Systems Pharmacology Software
#484
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Whole-body PBPK with tissue TMDD modelling to predict determining parameters of target occupancy in tissues
#483
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Physiologically-based Pharmacokinetics modelling to predict the systemic exposure of medicines in infants via breastmilk: a contribution from the ConcePTION Project.
#482
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: Quantitative Systems Pharmacology of Interferon Alpha Administration and its induced cellular response in mice
#481
Yuri05
opened
1 year ago
0
Poster at PAGE 2023: 4ß-OH Cholesterol as endogenous biomarker for CYP3A4 inducer DDI studies – a PBPK-QSP platform for in silico compound testing
#480
Yuri05
opened
1 year ago
0
Application of machine learning in combination with mechanistic modeling to predict plasma exposure of small molecules
#479
Yuri05
opened
1 year ago
0
Mechanistic Modeling of the Drug-Drug Interaction Between Efavirenz and Dolutegravir: Is This Interaction Clinically Relevant When Switching From Efavirenz to Dolutegravir During Pregnancy?
#478
Yuri05
opened
1 year ago
0
Physiologically based pharmacokinetic modeling of levetiracetam to predict the exposure in hepatic and renal impairment and elderly populations
#477
JanSchlender
opened
1 year ago
0
Physiologically Based Pharmacokinetic (PBPK) Modelling of Oral Drug Absorption in Older Adults – an AGePOP review
#476
JanSchlender
opened
1 year ago
0
Physiologically based pharmacokinetic modeling of bergamottin and 6,7-dihydroxybergamottin to describe CYP3A4 mediated grapefruit-drug interactions
#475
JanSchlender
opened
1 year ago
0
Predicting Hydroxychloroquine Clearance in Healthy and Diseased Populations Using a Physiologically Based Pharmacokinetic Approach
#474
Yuri05
opened
1 year ago
0
Physiologically Based Pharmacokinetic Modeling for Multiple Oral Administration Labetalol in Pregnant Women
#473
Yuri05
opened
1 year ago
0
Prediction for Plasma Trough Concentration and Optimal Dosing of Imatinib under Multiple Clinical Situations Using Physiologically Based Pharmacokinetic Modeling
#472
Yuri05
opened
1 year ago
0
Model-Based Analysis of In Vivo Release Data of Levonorgestrel Implants: Projecting Long-Term Systemic Exposure
#471
Yuri05
opened
1 year ago
0
Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the ConcePTION Project
#470
Yuri05
opened
1 year ago
0
Physiologically Based Pharmacokinetic Modeling of Quinidine to Establish a CYP3A4, P-gp and CYP2D6 Drug-Drug-Gene Interaction Network
#469
Yuri05
opened
1 year ago
0
Physiologically based pharmacokinetic modelling to predict intragastric rifabutin concentrations in the treatment of Helicobacter pylori infection
#468
JanSchlender
opened
1 year ago
1
Develop adult extrapolation to pediatrics and pediatric dose optimization based on the physiological pharmacokinetic model of azithromycin
#467
JanSchlender
opened
1 year ago
0
Physiologically based pharmacokinetic-pharmacodynamic evaluation of meropenem in CKD and hemodialysis individuals
#466
JanSchlender
opened
1 year ago
0
Physiologically-based pharmacokinetic modeling-guided rational combination of tacrolimus and voriconazole in patients with different CYP3A5 and CYP2C19 alleles
#465
JanSchlender
opened
1 year ago
0
Development and Validation of Physiologically Based Pharmacokinetic Model of Levetiracetam to Predict Exposure and Dose Optimization in Pediatrics
#464
JanSchlender
opened
1 year ago
0
Physiologically-based pharmacokinetic modeling to inform combination dosing regimens of ceftaroline and daptomycin in special populations
#463
JanSchlender
opened
1 year ago
0
Physiologically-based pharmacokinetic modeling to inform dosing regimens and routes of administration of rifampicin and colistin combination against Acinetobacter baumannii
#462
JanSchlender
opened
1 year ago
0
Model-informed approach to support Pediatric Dosing for the Pan-PI3K Inhibitor Copanlisib in Children and Adolescents with Relapsed/Refractory Solid Tumors
#461
JanSchlender
opened
1 year ago
0
The Analysis of Pethidine Pharmacokinetics in Newborn Saliva, Plasma, and Brain Extracellular Fluid After Prenatal Intrauterine Exposure from Pregnant Mothers Receiving Intramuscular Dose Using PBPK Modeling
#460
AndreDlm
opened
1 year ago
0
Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of Alprazolam: Implications for Anxiety and Addiction
#459
AndreDlm
opened
1 year ago
0
Novel approach for verification of a human PBPK modeling strategy using chimeric mice in the health risk assessment of epyrifenacil
#458
JanSchlender
opened
1 year ago
0
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