Open-Systems-Pharmacology OSP-based-publications-and-content issues

Open-Systems-Pharmacology / OSP-based-publications-and-content

Publications of all kind based on the Open Systems Pharmacology Suite

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Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models

#364 JanSchlender opened 2 years ago
0
Use of physiologically-based pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity

#363 JanSchlender opened 2 years ago
0
Renal transporter-mediated drug-biomarker interactions of the endogenous substrates creatinine and N1-methylnicotinamide: a PBPK modeling approach

#362 JanSchlender opened 2 years ago
0
Determining the Efects of Chronic Kidney Disease on Organic Anion Transporter1/3 Activity Through Physiologically Based Pharmacokinetic Modeling

#361 JanSchlender opened 2 years ago
0
Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling of Diazepam: Unbound Interstitial Brain Concentrations Correspond to Clinical Endpoints

#360 JanSchlender opened 2 years ago
0
Pharmacokinetic Prediction of CYP2D6 Genotypes of Metoclopramide in Adults and Children Using Physiologically Based Pharmacokinetic Modeling

#359 JanSchlender opened 2 years ago
2
Dosage Appropriacy Evaluation of Oral Venlafaxine Related to CYP2D6 Genotype Using Physiologically Based Pharmacokinetic (PBPK) Model

#358 JanSchlender opened 2 years ago
0
Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation of Lornoxicam to Develop Personalized Drug Optimization regarding to CYP2C9 Genetic Polymorphism

#357 JanSchlender opened 2 years ago
0
Novel intranasal treatment for anxiety disorders using amiloride, an acid-sensing ion channel antagonist: Pharmacokinetic modeling and simulation

#356 JanSchlender opened 2 years ago
0
Use of Real-World Data and Physiologically-Based Pharmacokinetic Modeling to Characterize Enoxaparin Disposition in Children with Obesity

#355 JanSchlender opened 2 years ago
0
Development of Physiologically Based Pharmacokinetic Model and Assessment of the Impact of Renal Underdevelopment in Preterm Infants on the Pharmacokinetics of Aminophylline

#354 Yuri05 opened 2 years ago
0
PK-Sim® for Modeling Oral Drug Delivery of Modified-Release Formulations

#353 Yuri05 opened 2 years ago
0
Quality Assurance of PBPK Modeling Platforms and Guidance on Building, Evaluating, Verifying and Applying PBPK Models Prudently under the Umbrella of Qualification: Why, When, What, How and By Whom?

#352 Yuri05 opened 2 years ago
0
Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug–Drug–Gene Interaction Predictions

#351 Yuri05 opened 2 years ago
0
Physiologically-based pharmacokinetic modeling of nafamostat to support dose selection for treatment of pediatric patients with COVID-19

#350 Yuri05 opened 2 years ago
0
Physiologically-based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups

#349 JanSchlender opened 2 years ago
0
Prediction of lung exposure to anti-tubercular drugs using plasma pharmacokinetic data: implications for dose selection

#348 JanSchlender opened 2 years ago
0
Physiologically Based Pharmacokinetic Modeling of Metformin in Children and Adolescents with Obesity

#347 JanSchlender opened 2 years ago
0
Development of a Generic Physiologically Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk

#346 AndreDlm opened 2 years ago
1
Model-Based Assessment of the Contribution of Monocytes and Macrophages to the Pharmacokinetics of Monoclonal Antibodies

#345 JanSchlender opened 2 years ago
0
The Development of a PBPK Model for Atomoxetine Using Levels in Plasma, Saliva and Brain Extracellular Fluid in Patients with Normal and Deteriorated Kidney Function

#344 JanSchlender opened 2 years ago
0
Physiologically Based Pharmacokinetic Modeling in Pregnant Women Suggests Minor Decrease in Maternal Exposure to Olanzapine

#343 AndreDlm opened 2 years ago
0
Prediction of CYP-mediated silybin A-losartan pharmacokinetic interactions using physiological based pharmacokinetic modeling

#342 JanSchlender opened 2 years ago
0
Use of Physiologically-Based Kinetics Modelling to Reliably Predict Internal Concentrations of the UV Filter, Homosalate, After Repeated Oral and Topical Application

#341 abdullahhamadeh opened 2 years ago
0
Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children

#340 abdullahhamadeh opened 2 years ago
0
Hands-on: Introduction to physiologically-based pharmacokinetic modeling with PK-Sim

#339 Incei opened 2 years ago
0
A Mechanistic Bayesian Inferential Workflow for Estimation of In Vivo Skin Permeation From In Vitro Measurements

#338 JanSchlender opened 2 years ago
0
Physiologically based pharmacokinetic (PBPK) modeling of meloxicam in different CYP2C9 genotypes

#336 Yuri05 opened 2 years ago
0
Physiologically-Based Pharmacokinetic Modeling of Oxcarbazepine and Levetiracetam During Adjunctive Antiepileptic Therapy in Children and Adolescents

#335 Yuri05 opened 2 years ago
0
Physiologically based pharmacokinetic modeling of candesartan related to CYP2C9 genetic polymorphism in adult and pediatric patients

#334 Yuri05 opened 2 years ago
0
Whole Body PBPK Modeling of Remdesivir and its Metabolites to Aid in Estimating Active Metabolite Exposure in the Lung and Liver in Patients with Organ Dysfunction

#333 Yuri05 opened 2 years ago
0
Physiologically-based pharmacokinetic modeling to predict CYP3A4-mediated drug-drug interactions of finerenone

#332 JanSchlender opened 2 years ago
0
Determining the Exposure Threshold for Levonorgestrel Efficacy Using an Integrated Model Based Meta-Analysis (MBMA) Approach

#331 JanSchlender opened 3 years ago
1
Leveraging translational approaches for accelerated clinical development of vericiguat

#330 JanSchlender opened 3 years ago
1
Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling

#329 AndreDlm opened 3 years ago
0
Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions

#328 JanSchlender opened 3 years ago
0
Mechanistic Modeling of Placental Drug Transfer in Humans: How Do Differences in Maternal/Fetal Fraction of Unbound Drug and Placental Influx/Efflux Transfer Rates Affect Fetal Pharmacokinetics?

#327 AndreDlm opened 3 years ago
1
Mechanistic Coupling of a Novel in silico Cotyledon Perfusion Model and a Physiologically Based Pharmacokinetic Model to Predict Fetal Acetaminophen Pharmacokinetics at Delivery

#326 AndreDlm opened 3 years ago
0
Dosing Regimen Prediction and Confirmation with Rivaroxaban for Thromboprophylaxis in Children after the Fontan Procedure: Insights from the Phase III UNIVERSE Study

#325 JanSchlender opened 3 years ago
0
Evaluation of the Drug-Drug Interaction Potential of Treosulfan using a Physiologically-Based Pharmacokinetic Modelling Approach

#324 JanSchlender opened 3 years ago
0
Comparing Predictions of a PBPK Model for Cyclosporine With Drug Levels From Therapeutic Drug Monitoring

#322 JanSchlender opened 3 years ago
0
Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment

#321 JanSchlender opened 3 years ago
0
A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68 Ga-DOTATATE in patients without neuroendocrine tumors

#320 JanSchlender opened 3 years ago
0
A cross-species comparison of antiretroviral penetration into lymph nodes using novel physiologically based pharmacokinetic models

#319 AndreDlm opened 3 years ago
0
Physiologically-based Pharmacokinetic Modeling to Assess the Impact of CYP2D6-Mediated Drug-Drug Interactions on Tramadol and O-Desmethyltramadol Exposures via Allosteric and Competitive Inhibition

#318 JanSchlender opened 3 years ago
0
Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically-based pharmacokinetic predictions

#317 JanSchlender opened 3 years ago
0
Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism

#316 JanSchlender opened 3 years ago
0
Evaluation for Potential Drug–Drug Interaction of MT921 Using In Vitro Studies and Physiologically–Based Pharmacokinetic Models

#315 JanSchlender opened 3 years ago
0
Design of a PBPK model in PK-Sim (in Spanish)

#314 Yuri05 opened 3 years ago
0
In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

#313 Yuri05 opened 3 years ago
0

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