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Hi
I am trying to generate polygenic scores using PRSice v2 **without phenotype data for the target population**. i.e. I just want to use the GWAS summary statistics (and specifically the effect si…
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We've got two nice use cases of population and statistical genetics; a third use case that could attract users and contributors could be polygenic risk score computations.
I'm only glancingly famil…
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Could ingest PRS, and maybe HLA freq data
https://www.preprints.org/manuscript/202003.0356/v1
@pnrobinson - interested in your thoughts
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This is not strictly in the domain of Mondo but Mondo is where most people see this - e.g. when browsing for genes associated with breast cancer on the monarch site
OMIM has an entry
https://omi…
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Hi , I am getting the following error. I was attempting to use a different GWAS sumstat with the test target data and it keeps getting stuck on this error.
Error in rule prep_pgs_lassosum_i:
…
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Right now OakVar does not support outputting polygenic risk scores results. At the same time we are working on it and also there are many public catalogs like https://www.pgscatalog.org/ with many PRS…
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Dear Florian
Firstly, I'd like to thank you for developing a robust PRS method, SCT.
I am reproducing the result of 'Making the Most of Clumping and Thresholding for Polygenic Scores'. However, …
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Hi @privefl , @tshmak
I am benchmarking PRS/PGS methods practiced in the [PRS tutorial](https://choishingwan.github.io/PRS-Tutorial/). Regard to Lassosum, I got some confusions. I'd appreciate if…
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Hi Daniel,
My name is Nilesh Dharajiya, MD, and I am a molecular pathologist by training. I came across het.io recently and am very impressed by it. I have been playing with Neo4j since last 3 yea…
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Hello,
I ran the --blup option and I obtained a Beta for each trait that I used in the meta-analysis.
Is there another option to compute also the SE?
Also my understanding from some of the previ…