-
Hello and congrats again to the Baker lab for the well-deserved Nobel Prize!
I'm trying to achieve the functionality of RFDiffusion+ProteinMPNN with Protein Generator. I have tested on three system…
-
Hello and great job on the tool! I'm trying to make a substructure conditioner based on one region of protein A and apply that to a similar region of protein B. However, because the proteins A/B have …
-
- [ ] icons for all 20 canonical amino acids and protonation states
- [ ] coevolution
- [ ] salt bridge icon
- [ ] epistasis icon
- [ ] interaction network in protein
Inspiration
![image](h…
-
Hi Sean,
Amazing work. Thank you for sharing your work and your code.
I am curious about the protein MPNN score. Why do you give the chain to design as "A" and take the local score only? Why not u…
-
Hi,
I have a basic question about the usage of PepMLM. I would like to design a binder for a target protein sequence that is ~20aa. I would like the designed protein to be around ~80aa long.
I …
-
Hi Brian,
I have a couple of bioinfo tools that I "ported" to modal (blat, STAR, https://github.com/tdsone/modal-rna-seq-pipeline). Do you think this would be useful in biomodals as well (biomodal…
-
Could we use this code against protein structure so it can design small drug like molecules against targeted structure ? If yes any details?
-
Hello, I am using your pipeline to design hemoglobin binding protein. When I run the code segment "Analyzing diffusion outputs," I encounter the following error. Thank you very much for your help.
…
-
Dear Author,
Thank you for your outstanding work on CLEAN. In my current research, I am attempting to design enzyme proteins from scratch and using CLEAN to predict EC numbers. At what confidence t…
-
Hi, Dr. Song,
Thanks for sharing the code. SurfPro is an excellent work in starting to design protein based on molecular surfaces.
However, I wonder which category surface you used in MSMS. Di…