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Firstly I used de novo binder design --> only 1-helix binder protein will be designed.
Then, I am using scaffold-based binder design by using the given 1000 scaffolds --> only 3-helix binder protein …
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Thank you for this incredible software, and for making it freely available!
I would like to know if it is possible to diffuse protein binders using RFdiffusion all-atom, specifically where one or b…
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### Description of the bug
Hi all, I keep encountering the following error on diverse datasets that I am trying to use with quantms. I have tried it multiple times on the same HPC cluster but with di…
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Awesome work :)
I am thinking about finetuning this model on specific protein domain with MLM task.
As in, starting from the SaProt model weights, further finetuning on un-labeled dataset.
1. W…
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So, I have an example **protein A** that is very similar to my **protein B** I aim to study. The **protein A** has a binder **A-binder**, and I use **A-binder** as a scaffold to design my binder **B-b…
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Hi,
When running test_diff the order of factors/covariates in the design matrix affects the final analysis.
I have put this issue up on BioStars: https://www.biostars.org/p/9588610/#9602501 and …
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**User Story**
As a researcher, I want to have more information available about my data (e.g. proteins) so that I do not have to switch to other sources and can find important information quickly…
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Your work is excellent, and I want to design small molecule binding proteins with your moldes. But I'm afraid I can't understand the meaning of these parameters, after consulting Extended Data Fig. 6 …
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So, I have an example **protein A** that is very similar to my **protein B** I aim to study. The **protein A** has a binder **A-binder**, and I use **A-binder** as a scaffold to design my binder **B-b…
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Sorry for the silly question. Probably there is also an easy way to find out the solution. However, I am not that experienced with computational protein design.
I want to specify that I want to in…