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**Which problem would you like to address? Please describe.**
Currently, PEtab does not allow to express nonlinear mixed effects models (i.e containing fixed (population) and random (patient-specific…
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Each SS defines default values of "isPresent" and "Negative values allowed" for certain types of molecules (floating compounds, enzymes, transporters) (selctable via a check-box).
![image](https:/…
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It was indicated in the manual that "If an inhibition is set up for an enzyme or transporter, all processes with the same name will be linked and affected by the inhibition. An autoinhibition cannot b…
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I'm encountering difficulties while attempting to estimate a whole-body PBPK model using nlmixr2. Previously, the model functioned properly, but now it fails to estimate the data accurately. Instead, …
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Now cvode seems to be a reliable solver for stiff problems, but we still run into numerical issues from time to time (well we do go complex, but still).
I am just wondering if we are sqeezing every…
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Hi,
I am using Matlab 2018b and OSP version 7.4.0.
Recently, on one of my exports I got the error raised in the issue #96 and I executed the required steps:
- Restart Matlab
- Add pa…
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There are 53 duplicated classes (same label with different IRIs) in eNM ontology:
1. grade 2 hematoma ae
http://purl.obolibrary.org/obo/OAE_0003031
http://purl.obolibrary.org/obo/OAE_0003581
2…
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In the hierarchy view, show **all** parameters of the model.
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https://pubmed.ncbi.nlm.nih.gov/38140105/
Pharmaceutics. 2023 Dec 12;15(12):2765.
Wei Zhang, Qian Zhang, Zhihai Cao, Liang Zheng, Wei Hu
Abstract
Rational drug use in special populations is a c…
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### Discussed in https://github.com/nlmixr2/nlmixr2/discussions/227
Originally posted by **afee36912** May 6, 2024
I repeatedly keep on getting an unhandled error message for the lsoda solver…