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This is not strictly in the domain of Mondo but Mondo is where most people see this - e.g. when browsing for genes associated with breast cancer on the monarch site
OMIM has an entry
https://omi…
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We've got two nice use cases of population and statistical genetics; a third use case that could attract users and contributors could be polygenic risk score computations.
I'm only glancingly famil…
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Could ingest PRS, and maybe HLA freq data
https://www.preprints.org/manuscript/202003.0356/v1
@pnrobinson - interested in your thoughts
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Right now OakVar does not support outputting polygenic risk scores results. At the same time we are working on it and also there are many public catalogs like https://www.pgscatalog.org/ with many PRS…
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Hello,
I ran the --blup option and I obtained a Beta for each trait that I used in the meta-analysis.
Is there another option to compute also the SE?
Also my understanding from some of the previ…
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## Feature request
From the documentation details about `enter_object()`:
> After using enter_object, all further tidyjson calls happen inside the referenced object (all other JSON data outside…
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As our work on this package progress, this issue can help us enumerate possible future features of the package depending on the time and interests of contributors. Some features will be needed for th…
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Here we consider the types of higher-order **clinical significance** annotations that link 'variants' to 'conditions' to which they might contribute or impact clinical management of, and which we migh…
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Hey, it's not an issue, but rather a prospective question, hope someone would be able to answer it.
I'm planning to run several thousand individual GWASs on a set of brain imaging measures within th…
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I am trying to use LDpred-funct in order to generate a polygenic risk score from a summary statistic. I am following the tutorial reported here but I have some questions:
At first, I used S-LDSC in…