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Hi.
I've read your CNV signature paper (the Preprint version) previously. At that time, the total number of signature was 19. When I read the related paper published in Nature, I found the total numb…
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S4 panels will need to be re-compiled into an overall figure.
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The plot_mutational_signatures function takes up-to 600G memory to generate signature_contributions.pdf for pcawg_COMPOSITE.
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The mutational signatures module cobbles together several distinct analyses, many of which are not part of the manuscript but take _significant_ of memory and time. To facilitate running the most rele…
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Hi!
Thanks for your work on this tool.
I'm currently trying to run this tool on a set of Bladder cancer patients who've undergone Platinum chemo. As such I wanted both SBS31 and SBS35 to be accoun…
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The current figure for mutational signatures is very nice. I am however worried that there may be problems with fitting. The "flat signatures" tend to have problems in this regard, of which Signature …
arpoe updated
2 years ago
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Hi,
I'm encountering some inconsistent de novo signature extraction results. Some sets of samples extract SBS3, others SBS5, others SBS40, even though all of them have fairly similar full spectra.
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gevro updated
2 years ago
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Per my comments on #1365, some LGG `cancer_group` updates were implemented, but never transferred to `pbta-histologies.tsv`. This resulted in separate `cancer_group` in plots for `Low-grade glioma ast…
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Dear developers,
Thank you for the very useful tool. I am working with skin cancers and remember that in the original publication 3-nucleotide mutational signature was not enough to correct for DnD…
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Hi.
I'm wondering if there is any difference between Assignment and SingleSample in attributing known mutational signatures (for example, COSMIC signatures) to a given sample. Which one is recommende…