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### Submitter Name
Alex Wagner
### Submitter Affiliation
Nationwide Children’s Hospital
### Submitter Github Handle
Ahwagner
### Additional Submitter Details
_No response_
### …
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TautomerEnumerator() removes chirality on all input atoms, not only the ones involved in the tautomerisation rearrangements.
**To Reproduce**
from rdkit.Chem.MolStandardize import rdMolStandardi…
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The VCF parser is currently unable to parse VCFs with complex rearragnements and this is showing up as Picard issues: https://github.com/broadinstitute/picard/issues/1406
Need to prioritize and fix…
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Consider implementing support for pairix indexed bgzip files:
https://github.com/4dn-dcic/pairix#pairix
This essentially allows bedpe files to be 2D indexed.
This is likely a solution to any …
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Our colors in dark theme are based on those in web. The dark theme in web is getting adjusted to have slightly higher contrast, and we should follow. Details:
* https://chat.zulip.org/#narrow/stream/…
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This is a summary of conversation with @OmarDuran, who gets all credits for the observations reported below.
It turns out there is a memory leakage related to the function `pp.matrix_operations.inv…
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A couple of questions that came up in an iReceptor Plus meeting today:
- From an ADC perspective, repertoire_ids are typically unique within a given context (in the ADC they are unique within a rep…
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Hi oxygen311,
I've installed parebricks with `conda install -c conda-forge -c bioconda PaReBrick`. When I try to run the provided example code, I get the following error; any thoughts (e.g. is ther…
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`chr7 68922689 Minda_135 N N]chr7:68930585] . PASS SVLEN=7896;SVTYPE=BND;SUPP_VEC=PB_severus_INV6737,PB_r_320_1,ONT_severus_INV7748,ONT_r_211_1,ILL_gridss130ff_2083h,ILL_MantaBND:131944:0:1:0:0:0:0,PB…
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`chr18 22492810 Minda_59 N . PASS SVLEN=730112;SVTYPE=DUP;SUPP_VEC=PB_severus_DUP2962,PB_r_191,ONT_severus_DUP3355,ONT_r_113,ILL_MantaDUP:TANDEM:239447:0:1:0:0:0,PB_ID_40649_2,ONT_ID_69814_2,ILL_2890…