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Dear MetaMorpheus developers.
We are using a new enzyme for our bottom-up proteomics:
https://www.sciencedirect.com/science/article/pii/S1535947620600172
ProAlanase cuts at the c-terminus of Ala …
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I have two questions regarding spectral library generation function in DIA-NN.
1. To generate a spectral library for library-free search, is it possible to use a FASTA that contains only peptide se…
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ZBP1 is targeted by several DNA viruses and the influenza virus that replicates in the host nucleus. After associating with some factor, probably viral, ZBP1 associates with TBK1 and IRF3 and regulate…
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For Atrolysin-E from Crotalus atrox (some rattlesnake): This proteolytic toxin degrades extracellular matrix proteins [PMID2817904]. Rattlesnake hemorrhagic toxin can disable the circulatory system b…
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**Proposal for 7 B.1.617.2 sub-lineages in the UK**
by Chris Ruis
**Description**
Sub-lineages of B.1.617.2
These are clades within B.1.617.2 that contain predominantly UK sequences and have at …
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Currently the GUI limits max. missed cleavages to 3. For most proteases this is okay but pepsin and similar promiscuous proteases generate peptides that may have many more than this.
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@peastman : Given the [painful lessons from the OpenMM 7.6 release](https://github.com/openmm/openmm/issues/3232), I wanted to open a thread to discuss the steps we are taking to ensure we don't repea…
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Hi!
I've used FragPipe on a local Windows machine for optimization of our workflow, but want to run it on a high performance cluster with X11 forwarding for the actual analyses.
Unfortunately, …
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Hi,jiarong ,
This software helps me a lot when I try to find the virus sequence in the metagenomic data. I found the viruses were classified into three categories as you described in the paper, but I…
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With the current cleavage regex of chymotrypsin and IL_equivalent, PeptideIndexer always has unmatched peptides.
IL_equivalent replaces Ls with Is but the current regex only includes L (and J):
`[…