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We've got two nice use cases of population and statistical genetics; a third use case that could attract users and contributors could be polygenic risk score computations.
I'm only glancingly famil…
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Could ingest PRS, and maybe HLA freq data
https://www.preprints.org/manuscript/202003.0356/v1
@pnrobinson - interested in your thoughts
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I'm testing whether MTAG can help with polygenic risk score prediction for a pair of traits with poor genetic correlation. My primary phenotype is bipolar disorder (BIP), and I performed MTAG on BIP v…
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This is not strictly in the domain of Mondo but Mondo is where most people see this - e.g. when browsing for genes associated with breast cancer on the monarch site
OMIM has an entry
https://omi…
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hello,Can the polygenic risk score be calculated using the pleiotropy loci found by PLEIO? In addition, MTAG requires that the correlation between multiple traits is more than 0.7. I think it is menti…
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Hi Bjarni,
Thanks for your time.
I have some questions about the reference panel and target genotype.
1. The reference panel should follow --gf and the target genotype should follow --vgf. Is…
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Hi Sam,
Thanks for the great tutorial. I have been trying PLINK for the polygenic risk score. However, with the height dataset and EUR plink files, I am not able to reproduce the results. Especially,…
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As mentioned in [3436,](https://github.com/opentargets/issues/issues/3436) the credible set page will also contain:
3. Co-loc with GWAS SNPs - scoping in progress
4. Co-loc with QTLs - scoping in …
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Right now OakVar does not support outputting polygenic risk scores results. At the same time we are working on it and also there are many public catalogs like https://www.pgscatalog.org/ with many PRS…
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## Feature request
From the documentation details about `enter_object()`:
> After using enter_object, all further tidyjson calls happen inside the referenced object (all other JSON data outside…