hclimente / spada

⚔️Find splicing-led, functional changes of the proteome.
MIT License
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alternative-splicing isoform-switches protein-protein-interaction protein-structure python

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spada

spada (Splicing-led Protein Alterations Discovered Agilely) is a tool to study the functional impact of alternative splicing changes in case-control studies. The alterations are represented as isoform switches i.e. the situation when cases are best represented by one isoform, while controls are best represented by a different one. Then, spada is able to predict which protein features are changing between both isoforms, and their impact on the protein-protein interaction network.

To start using spada, simply install it with

pip install spada

This package has two main functionalities:

For detailed information on how to use spada, please visit the wiki.

Documentation

Citation

If you use spada in a scientific publication, we would appreciate citations:

Climente-González, H., Porta-Pardo, E., Godzik, A., and Eyras, E. (2017). The Functional Impact of Alternative Splicing in Cancer. Cell Reports 20, 2215–2226.

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