tensfeldt openNCA issues

tensfeldt / openNCA

openNCA computation engine is an R package that provides for generation of pharmacokinetic parameter estimates using non-compartmental (NCA) pharmacokinetic analysis methods.

MIT License

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issues

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manual fix NAMESPACE

#301 roninsightrx opened 6 months ago
4
FLGAACCEPTTAU isn't computed properly if PK Analyst modifies the default acceptance criteria

#300 tensfeldt opened 1 year ago
0
Specifying alternate name for SDEID in model configuration template not working

#299 TomTensfeldt opened 1 year ago
0
LASTTIME not equal to TLAST following point exclusion

#298 tensfeldt opened 2 years ago
0
When value of a field included in a DATADISPLAYLIST item = "F", the entire field is converted to a logical rather than retained as character

#297 tensfeldt opened 2 years ago
0
openNCA_Computation_Engine_v1.0

#296 tensfeldt closed 2 years ago
0
AUCLASTC is computed incorrectly in some cases

#295 tensfeldt opened 2 years ago
0
MRTIVIFP is computed incorrectly using the SS Bolus IV Model rather than the SS Infusion Model

#294 tensfeldt opened 2 years ago
0
Add "impute_missing_predose_records" option for Single Dosing

#293 tensfeldt opened 2 years ago
0
LLOQPATTERNS from Model Configuration Template not implemented

#292 tensfeldt opened 3 years ago
1
openNCA CE release 3.0.2 missing DOSE and DOSEUNI variables cause error but should be allowed and prompt utilization of unit DOSE

#291 tensfeldt opened 3 years ago
2
Add specifics of handling DUPLICATE record scenarios in STDOUT messages

#290 tensfeldt opened 3 years ago
0
OPTIMIZEKEL routine incorrectly adds SDEID value to resulting updated FLAGS dataset

#289 tensfeldt opened 3 years ago
0
Provide a mechanism to optionally include/exclude incorporate of CONC<#>, CONCTIME<#> values in parameter results dataset

#288 tensfeldt opened 3 years ago
0
When Actual Time is specified through the MCT$TIME configuration, Computation Engine generates empty cumulative AUCs, AUCDNs, CONC, CONCTIME

#287 tensfeldt opened 3 years ago
0
OPTIMIZEKEL fails when profile is missing all concentration records

#286 tensfeldt opened 3 years ago
0
run_computation fails when mct$SDEID value doesn't match "SDEID"

#285 tensfeldt opened 3 years ago
0
Imputation of concentration==0 when no concentration record appears at TIME==0/time of dose for Model 1 Single Dose

#284 tensfeldt opened 3 years ago
0
Partial AUCs fail to compute if missing concentration values appear in the "middle" of the profile

#283 tensfeldt opened 3 years ago
0
DOSEC is not being computed nor any dependent parameters with CONC specified in NGEQ/ML

#280 tensfeldt opened 3 years ago
0
FLGTIME time switch capability does not work

#279 tensfeldt opened 3 years ago
0
FLGEMESIS is not sourced from input dataset

#277 tensfeldt opened 3 years ago
0
commit build c3d3f48 has unresolved dependencies in the package build process

#276 tensfeldt opened 3 years ago
0
AUCTAU and AUMCTAU are not correctly computed when CMIN>0, TAU1 occurs before TLAST, first datapoint occurs at a time >0

#275 tensfeldt opened 4 years ago
0
2020-10-15 tc1578 incorrect error message concerning value of OPTIMIZEKEL

#274 tensfeldt opened 4 years ago
0
2020-10-05 tc131_M1SS fails if OPTIMZEKEL isn't defined in MCT

#273 tensfeldt opened 4 years ago
0
2020-10-05 tc131_M1SS fails with commits cca452d and 472a0a2 due to missing OPTIMIZEKEL in MCT

#272 tensfeldt opened 4 years ago
0
2020-09-01 tc1577_M1SS-2 AUCT is missing and resets for subsequent AUCT for first AUCT to include TAU1

#271 jhhughes256 closed 4 years ago
1
2020-09-30 tc158_M1SS AUC10_24 no longer generated for single dosing interval profiles introduced with 472a0a2

#270 jhhughes256 closed 4 years ago
1
2020-09-16 tc1578_M1SD FLGACCEPTTMAX is not set correctly where TMAX < 2*Median(TMAX) for the treatment/dose

#269 tensfeldt closed 4 years ago
1
2020-09-11 tc1704_M3SS CMIN is not included at pre-dose/zero concentration for the parameter AUCLAST

#268 TomTensfeldt closed 4 years ago
1
2020-09-10 tc1669_M4SS fails to execute

#267 TomTensfeldt closed 4 years ago
1
2020-09-07 tc119_M1SD optimizekel routine fails with mct$OPTIMIZEKEL==1, optimization fails criteria with mct$OPTIMIZEKEL==2

#266 TomTensfeldt opened 4 years ago
1
2020-09-02 tc1510-1 M1SD partial AUCs including an NA concentration not generated

#265 jhhughes256 closed 4 years ago
1
2020-09-01 tc1580 M3SS inconsistent output for SDEID profiles that contain negative times

#264 jhhughes256 closed 4 years ago
2
2020-09-01 tc1577_M1SS-2 fails to execute with commit cca452d

#263 TomTensfeldt closed 4 years ago
2
2020-08-31 tc1661_M1SD_cca452d DOSE unit changes from DOSEUNI=MG/KG to HR in the units conversion routine even though DOSEOUTPUTUNIT == MG/KG

#262 TomTensfeldt closed 4 years ago
1
2020-08-28 tc1590_M1SD INCLUDEINTERPOLATION controls not working as expected or consistently.

#261 TomTensfeldt closed 4 years ago
3
2020-08-27 tc008 M4SS & tc103 M3SS undefined "DOSE" column execution error introduced with 35c2b2b

#260 jhhughes256 opened 4 years ago
0
2020-08-27 M1SS & M3SS execution error when all concentrations are NA introduced with e7df513

#259 jhhughes256 opened 4 years ago
0
2020-08-27 tc1606 M1SD & tc1607 M1SS "mr_auc_inf_p" & "mr_auc_inf_o" execution error when all values are NA or zero

#258 jhhughes256 opened 4 years ago
0
2020-08-27 tc123 M2SS "log(...): non-numeric argument" execution error introduced with 35c2b2b

#257 jhhughes256 opened 4 years ago
0
2020-08-27 tc105 & tc1572 M4SS "aetau: value 't' cannot be used to subset 'time'" execution error introduced in b1c7cff

#256 jhhughes256 opened 4 years ago
0
2020-08-27 openNCA-2.0.5-M1-Release commit cca452d config and build errors

#255 TomTensfeldt opened 4 years ago
0
2020-08-24 tc1702_M2SD Parameters not generated for profile with only 3 data points

#254 TomTensfeldt closed 4 years ago
1
2020-07-10 tc1401 AUCTAU with a single dosing interval has incorrect values

#253 TomTensfeldt closed 4 years ago
1
With Missing/Incorrectly Specified NORMBS/NORMBSU entries in MCT Computation Engine must not compute Body Size normalized Parameters

#252 TomTensfeldt opened 4 years ago
2
2020-06-08 Inconsistencies in create_dependency_list

#251 jhhughes256 opened 4 years ago
0
2020-05-28 tc1514 M2SS with actual time "isTRUE(time_min_range <= lastttime)" execution error introduced with e7df513

#250 jhhughes256 closed 4 years ago
2
2020-05-21 tc131 & tc133 M1SS + tc1514 M2SS "tau < orig_time..." execution error with actual time introduced with 786bf37

#249 jhhughes256 closed 4 years ago
2