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Hi,
I would like to make sure that the format of my input file is in the correct order to be analysed correctly. I used SigProfilerMatrixGenerator to produce my input file. In this file the row names…
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### Background
Pathogens' vaccine escape and drug resistance are examples of
evolutionary processes. The natural way to study this process is to
analyze the genomic sequence of pathogens. Accord…
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Dear all,
I'm trying to use SigProfilerExtractor on PCAWG data for an ongoing project. I managed to extract de novo signatures but something seems wrong with the reconstruction step. I attached th…
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Hi, the documentation for the "exome" flag states that if "exome=True", the matrix generator will "Downsample mutational matrices to the exome regions of the genome". If we are already using exome dat…
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Is it possible to extract the contribution of each sample to the extracted signatures?
Something like:
![image](https://user-images.githubusercontent.com/48090783/193022378-dc434c17-2722-4445-…
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https://mp.weixin.qq.com/s/zttX7tKl9uVPLtHrXqmRYg
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Hello,
Thanks for developing an excellent set of tools for this important field.
This is not a code issue, but more of an operational question, so I apologize for opening an issue, but it seems …
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Dear tool developers,
Thanks very much for the most recent updating of the tool. I'm trying
Sorry that I cannot figure out the error message my self. I will be super appreciated if could have som…
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Thank you for putting together this incredible resource for the analysis of somatic mutational signatures. Is it possible to provide an R markdown vignette for the signatureEstimation pipeline or othe…
nroak updated
2 years ago
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Hello! Looking at the COSMIC website, the ID signatures are all derived from build 37. Is it possible to extract COSMIC ID signatures from build 38 vcfs? Thanks for your time!