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Hi there,
I've been using the SigProfilerExtractorR tool to perform signature extraction and I'd like to view the signature decomposition results for multiple solutions (not just the suggested solu…
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I am using SigProfilerAssignment v0.0.24 and have been unable to decompose my de novo CN signatures. I was able to decompose them using v0.0.18. I extracted these signatures using SigProfilerExtractor…
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Hi,
I would like to make sure that the format of my input file is in the correct order to be analysed correctly. I used SigProfilerMatrixGenerator to produce my input file. In this file the row names…
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### Background
Pathogens' vaccine escape and drug resistance are examples of
evolutionary processes. The natural way to study this process is to
analyze the genomic sequence of pathogens. Accord…
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Hi, the documentation for the "exome" flag states that if "exome=True", the matrix generator will "Downsample mutational matrices to the exome regions of the genome". If we are already using exome dat…
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Dear all,
I'm trying to use SigProfilerExtractor on PCAWG data for an ongoing project. I managed to extract de novo signatures but something seems wrong with the reconstruction step. I attached th…
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Hello,
Thanks for developing an excellent set of tools for this important field.
This is not a code issue, but more of an operational question, so I apologize for opening an issue, but it seems …
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Is it possible to extract the contribution of each sample to the extracted signatures?
Something like:
![image](https://user-images.githubusercontent.com/48090783/193022378-dc434c17-2722-4445-…
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Thank you for putting together this incredible resource for the analysis of somatic mutational signatures. Is it possible to provide an R markdown vignette for the signatureEstimation pipeline or othe…
nroak updated
2 years ago
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https://mp.weixin.qq.com/s/zttX7tKl9uVPLtHrXqmRYg