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The code attempts a `full join` here:
https://github.com/cruk-mi/mesa/blob/212a791cb4da2d2d2c099c4ef53b4b71d5f1ee65/R/combineQsets.R#L193
But, when joining large `qseaSets`, the result is too mu…
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Is the tagged BAM output already corrected (i.e. adds/subtracts reads to account for GC bias based on correction weight matrix created)? Or does this need to be done after the fact?
Thanks!
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https://mp.weixin.qq.com/s/3b3j68dXLHZSHzCc1uVYJA
ixxmu updated
2 months ago
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Following discussion already have in post #2, I did some tests on two of our samples. However, I observe different results among them. Note that for the simplicity,
- the base calling is done wit…
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We noticed a strong drop in precision for SNVs (~10% for tumor-normal mode, ~20% in tumor-only mode) between releases 4.1.7.0 and 4.2.6.0.
With more testing using the HCC1395 somatic benchmark (https…
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Thank you for providing such a good tool. I am analyzing high depth sequencing data, and I want to correct the wrong sequence while removing PCR duplications. Does this tool compute a consensus seque…
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Questions for meeting on Fr 28.07.23:
howto configure SampleSheet to get:
- [x] BAM, VCF small variant, VCF structural variants
- [ ] benchmark with and without DRAGEN-ML (the on-site Dragen bench…
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encapsulate related functions into separate source files
- main app logic should only handle user arguments, high level logging and I/O, and then call services
- service module for communication with …
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When I try to calculate DMRs between SCLC and NCC cfDNA, the task exceeding the memory limit (100G) and I have to stop it.
```
qseaSetcfDNA %
calculateDMRs(variable = "tumour",
c…
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# 生信爱好者周刊（第 115 期）：罗莎琳德·富兰克林对DNA双螺旋结构的真实贡献
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