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Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells
#157
pnrobinson
closed
4 years ago
1
Develop
#156
pnrobinson
closed
4 years ago
0
Develop
#155
pnrobinson
closed
4 years ago
0
ARID1B is a specific vulnerability in ARID1A-mutant cancers
#154
pnrobinson
closed
4 years ago
1
Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing
#153
pnrobinson
closed
4 years ago
1
Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability
#152
pnrobinson
closed
4 years ago
1
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
#151
pnrobinson
closed
4 years ago
2
KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer
#150
pnrobinson
closed
4 years ago
2
Malignancy of Cancers and Synthetic Lethal Interactions Associated With Mutations of Cancer Driver Genes
#149
pnrobinson
closed
4 years ago
1
Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data
#148
pnrobinson
closed
4 years ago
1
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens
#147
pnrobinson
closed
4 years ago
1
Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells
#146
pnrobinson
closed
4 years ago
1
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels
#145
pnrobinson
closed
4 years ago
2
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner
#144
pnrobinson
closed
4 years ago
1
Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells
#143
pnrobinson
closed
4 years ago
2
Use of isogenic human cancer cells for high-throughput screening and drug discovery
#142
pnrobinson
closed
4 years ago
1
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
#141
pnrobinson
closed
4 years ago
1
Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers
#140
pnrobinson
closed
4 years ago
1
DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1
#139
pnrobinson
closed
4 years ago
2
Develop
#138
pnrobinson
closed
4 years ago
0
Merge pull request #136 from monarch-initiative/develop
#137
pnrobinson
closed
4 years ago
0
Develop
#136
pnrobinson
closed
4 years ago
0
Name change
#135
pnrobinson
closed
4 years ago
7
Parse depmap
#134
LeoPompidou
closed
4 years ago
0
Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival
#133
pnrobinson
closed
4 years ago
2
Develop
#132
pnrobinson
closed
4 years ago
0
Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma
#131
pnrobinson
closed
4 years ago
1
Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
#130
pnrobinson
closed
4 years ago
1
Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
#129
pnrobinson
closed
4 years ago
1
EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma
#128
pnrobinson
closed
4 years ago
1
Ataxia Telangiectasia-Mutated and Rad3-Related Inhibition and Topoisomerase I Trapping Create a Synthetic Lethality in Cancer Cells
#127
pnrobinson
closed
4 years ago
1
ATM inhibition induces synthetic lethality and enhances sensitivity of PTEN-deficient breast cancer cells to cisplatin
#126
pnrobinson
closed
4 years ago
1
BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
#125
pnrobinson
closed
4 years ago
1
E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer
#124
pnrobinson
closed
4 years ago
1
Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers
#123
pnrobinson
closed
4 years ago
1
Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma
#122
pnrobinson
closed
4 years ago
1
Transcriptomic rationale for synthetic lethality-targeting ERCC1 and CDKN1A in chronic myelomonocytic leukaemia
#121
pnrobinson
closed
4 years ago
1
SLFN11: a new synthetic lethal target?
#120
pnrobinson
closed
4 years ago
1
Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells
#119
pnrobinson
closed
4 years ago
2
Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia
#118
pnrobinson
closed
4 years ago
1
Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells
#117
pnrobinson
closed
4 years ago
1
Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors
#116
pnrobinson
closed
4 years ago
1
c-MYC Drives Breast Cancer Metastasis to the Brain, but Promotes Synthetic Lethality with TRAIL
#115
pnrobinson
closed
4 years ago
1
Targeting PARP1 in XRCC1-Deficient Sporadic Invasive Breast Cancer or Preinvasive Ductal Carcinoma In Situ Induces Synthetic Lethality and Chemoprevention
#114
pnrobinson
closed
4 years ago
1
Combined Blockade of Activating ERBB2 Mutations and ER Results in Synthetic Lethality of ER+/HER2 Mutant Breast Cancer
#113
pnrobinson
closed
4 years ago
1
C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event
#112
pnrobinson
closed
4 years ago
1
Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers
#111
pnrobinson
closed
4 years ago
2
Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene
#110
pnrobinson
closed
4 years ago
1
A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation
#109
pnrobinson
closed
4 years ago
1
Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer
#108
pnrobinson
closed
4 years ago
1
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