-
使用sig_fit函数直接拟合最新的COSMIC SBS的signature,尝试了好几个cohort,发现直接拟合出来的SBS组分中,总有较高比例的SBS39。但[Nature](http://www.nature.com/articles/s41586-020-1943-3)给的图中,SBS39的组分很少。
可以通过cBioportal的cohort来复现这一点,例如luad_cptac…
-
Hi Shixiang,
I am trying to apply sig_extract but failed with the following error message. The interesting thing is I can apply extractSignatures() successfully. What I need is to get the absolute…
-
https://mp.weixin.qq.com/s/rIFzAyqgJP_6ZtMJ9cvJZQ
ixxmu updated
8 months ago
-
Hi I want to ask if it is possible to include annotations by clinical variable at the bottom of exposure profile, just like the example figures I show here.
-
`PatientViewPageStore.ts` automatically sets the mutational signatures version to v2. This gives issues when there is no v2 present. It should automatically check for which versions are available and …
-
貼吧活動:(請查閱 [SARS-CoV-2 Timeline by 2020.02.21](https://github.com/agorahub/_meta/blob/agoran/theagora/sari/Memorandum_2020-02-21_SARS-CoV-2-Timeline_Nathan.pdf?raw=true), by Nathan :cloud: )
- Colla…
-
#### What analysis module should be updated and why?
https://github.com/PediatricOpenTargets/OpenPedCan-analysis/tree/dev/analyses/mutational-signatures
This analysis was updated in OpenPBTA t…
-
The `signature.tools.lib` R package needs to be added to the Dockerfile to run adult CNS mutational signature analysis in the [mutational-signatures analysis module](https://github.com/PediatricOpenTa…
-
Hi there,
I've been using the SigProfilerExtractorR tool to perform signature extraction and I'd like to view the signature decomposition results for multiple solutions (not just the suggested solu…
-
I am using SigProfilerAssignment v0.0.24 and have been unable to decompose my de novo CN signatures. I was able to decompose them using v0.0.18. I extracted these signatures using SigProfilerExtractor…